Disability-adjusted Long-term Prognosis in Ischemic Stroke Patients Using Stroke Registry

• Project/Area Number: 15K08849
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical and hospital managemen
• Research Institution: Kyushu University
• Principal Investigator: Matsuo Ryu 九州大学, 医学研究院, 助教 (60744589)
• Co-Investigator(Kenkyū-buntansha): 北園 孝成 九州大学, 医学研究院, 教授 (70284487) ; 鴨打 正浩 九州大学, 医学研究院, 教授 (80346783) ; 馬場園 明 九州大学, 医学研究院, 教授 (90228685)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脳卒中 / 障害調整生存率 / 血栓溶解療法 / 長期予後 / DALY / 予後 / コホート / 追跡調査

Outline of Final Research Achievements

We aimed to investigate the disability-adjusted long-term prognosis in ischemic stroke patients using stroke registry. The data such as events of recurrent stroke or death and functional outcome by modified Rankin Scale were collected during following 5 years after stroke onset, and disability-adjusted life year (DALY) was evaluated as disability-adjusted long-term prognosis. We examined the usefulness of intravenous thrombolysis for ischemic stroke patients using DALY. There was no difference in DALYs between treated group and non-treated group. In this study, stroke burden adjusted for age or disability was visualized by evaluating the raw data of ischemic stroke patients using stroke registry. It is suggested that the DALY may make an important role in the decision for medical politics and also contribute the improvement of quality of medical services.

Research Products

• [Journal Article] Insulin resistance and clinical outcomes after acute ischemic stroke (2018)
  • Author(s): Ago Tetsuro、Matsuo Ryu、Hata Jun、Wakisaka Yoshinobu、Kuroda Junya、Kitazono Takanari、Kamouchi Masahiro、On behalf of the Fukuoka Stroke Registry Investigators
  • Journal Title: Neurology Volume: 90 Issue: 17 Pages: e1470-e1477
  • DOI: 10.1212/wnl.0000000000005358
  • Peer Reviewed / Open Access
• [Journal Article] Safety of antithrombotic therapy for patients with acute ischemic stroke harboring unruptured intracranial aneurysm. (2018)
  • Author(s): Shono Y, Sugimori H, Matsuo R, Fukushima Y, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T; Fukuoka Stroke Registry Investigators..
  • Journal Title: Int J Stroke. Volume: 1 Issue: 7 Pages: 734-742
  • DOI: 10.1177/1747493018765263
  • Peer Reviewed / Open Access
• [Journal Article] Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke (2017)
  • Author(s): Matsuo Ryu、Yamaguchi Yuko、Matsushita Tomonaga、Hata Jun、Kiyuna Fumi、Fukuda Kenji、Wakisaka Yoshinobu、Kuroda Junya、Ago Tetsuro、Kitazono Takanari、Kamouchi Masahiro、on behalf of the Fukuoka Stroke Registry Investigators†
  • Journal Title: Stroke Volume: 48 Issue: 11 Pages: 3049-3056
  • DOI: 10.1161/strokeaha.117.018132
  • Peer Reviewed / Open Access
• [Journal Article] Left Atrial Size and Long‐Term Risk of Recurrent Stroke After Acute Ischemic Stroke in Patients With Nonvalvular Atrial Fibrillation (2017)
  • Author(s): Ogata Toshiyasu、Matsuo Ryu、Kiyuna Fumi、Hata Jun、Ago Tetsuro、Tsuboi Yoshio、Kitazono Takanari、Kamouchi Masahiro、the FSR Investigators
  • Journal Title: Journal of the American Heart Association Volume: 6 Issue: 8
  • DOI: 10.1161/jaha.117.006402
  • Peer Reviewed / Open Access
• [Journal Article] Adverse Influence of Pre-Stroke Dementia on Short-Term Functional Outcomes in Patients with Acute Ischemic Stroke: The Fukuoka Stroke Registry (2017)
  • Author(s): Yoshinobu Wakisaka, Matsuo Ryu, Jun Hata, Junya Kuroda, Takanari Kitazono, Masahiro Kamouchi, Tetsuro Ago
  • Journal Title: Cerebrovasc Dis Volume: 43 Issue: 1-2 Pages: 82-89
  • DOI: 10.1159/000453625
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Causes of Ischemic Stroke in Patients with Non-Valvular Atrial Fibrillation (2016)
  • Author(s): Asako Nakamura, Junya Kuroda, Tetsuro Ago, Jun Hata, Ryu Matsuo, Shuji Arakawa, Takahiro Kuwashiro, Masahiro Yasaka, Yasushi Okada, Takanari Kitazono, Masahiro Kamouchi, Fukuoka Stroke Registry Investigators
  • Journal Title: Cerebrovasc Dis Volume: 42 Issue: 3-4 Pages: 196-204
  • DOI: 10.1159/000445723
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Plasma C-reactive protein and clinical outcomes after acute ischemic stroke: A prospective observational study (2016)
  • Author(s): Ryu Matsuo, Tetsuro Ago, Jun Hata, Yoshinobu Wakisaka, Junya Kuroda, Takahiro Kuwashiro, Takanari Kitazono, Masahiro Kamouchi, Fukuoka Stroke Registry Investigators
  • Journal Title: PLoS One Volume: 11 Issue: 6 Pages: e0156790-e0156790
  • DOI: 10.1371/journal.pone.0156790
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Influence of Statin Pretreatment on Initial Neurological Severity and Short-Term Functional Outcome in Acute Ischemic Stroke Patients: The Fukuoka Stroke Registry (2016)
  • Author(s): Hiromi Ishikawa, Yoshinobu Wakisaka, Ryu Matsuo, Noriko Makihara, Jun Hata, Junya Kuroda, Tetsuro Ago, Jiro Kitayama, Hiroshi Nakane, Masahiro Kamouchi, Takanari Kitazono, Fukuoka Stroke Registry Investigators
  • Journal Title: Cerebrovasc Dis Volume: 42 Issue: 5-6 Pages: 395-403
  • DOI: 10.1159/000447718
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Short-term exposure to fine particulate matter and risk of ischemic stroke (2016)
  • Author(s): Ryu Matsuo, Takehiro Michikawa, Kayo Ueda, Tetsuro Ago, Hiroshi Nitta, Takanari Kitazono, Masahiro Kamouchi
  • Journal Title: Stroke Volume: 47 Issue: 12 Pages: 3032-3034
  • DOI: 10.1161/strokeaha.116.015303
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Prognosis in Mild or Rapidly Improving Ischemic Stroke Not Treated with Recombinant Tissue Plasminogen Activator: Fukuoka Stroke Registry (2018)
  • Author(s): Sakai S, Osaki M, Kimura S, Hidaka M, Arakawa S, Ago T, Matsuo R, Kamouchi M, Kitazono T
  • Organizer: International Stroke Conference 2018
  • Int'l Joint Research
• [Presentation] 脳梗塞患者の入院時アルブミンと予後の検討 －Fukuoka Stroke Registry－ (2018)
  • Author(s): 緒方利安、松尾 龍、吾郷哲朗、坪井義夫、北園孝成、鴨打正浩．
  • Organizer: 第42回 日本脳卒中学会学術集会総会
• [Presentation] インスリン抵抗性が急性期脳梗塞後の転帰に与える影響：the Fukuoka Stroke Registry． (2018)
  • Author(s): 松尾 龍、吾郷哲朗、秦 淳、脇坂義信、黒田淳哉、鴨打正浩、北園孝成．
  • Organizer: 第42回 日本脳卒中学会学術集会総会
• [Presentation] BUN/Crと虚血性脳血管障害後の短期的予後の検討: Fukuoka Stroke Registry． (2018)
  • Author(s): 大屋祐一郎、牧原典子、松尾 龍、森田隆雄、脇坂佳世、吾郷哲朗、竹迫仁則、鴨打 正浩、北園孝成．
  • Organizer: 第42回 日本脳卒中学会学術集会総会
• [Presentation] 未破裂脳動脈瘤を合併した脳梗塞患者に対する抗血栓療法の安全性：Fukuoka Stroke Registry (FSR) ． (2018)
  • Author(s): 生野雄二、松尾 龍、杉森 宏、脇坂義信、黒田淳哉、吾郷哲朗、鴨打正浩、北園孝成．
  • Organizer: 第42回 日本脳卒中学会学術集会総会
• [Presentation] 心房細動とアテローム血栓症を併せ持つ虚血性脳卒中患者の二次予防と予後:Fukuoka Stroke Registry． (2018)
  • Author(s): 木村俊介、大崎正登、坂井翔建、日高壮意、荒川修治、松尾 龍、鴨打正浩、吾郷哲朗、北園孝成．
  • Organizer: 第42回 日本脳卒中学会学術集会総会
• [Presentation] 頭蓋内脳動脈解離による虚血性脳卒中に対するrt-PA投与と有効性・安全性の検討：Fukuoka Stroke Registry． (2018)
  • Author(s): 坂井翔建、大崎正登、木村俊介、日高壮意、荒川修治、古田芳彦、吾郷哲朗、松尾 龍、鴨打正浩、北園孝成．
  • Organizer: 第42回 日本脳卒中学会学術集会総会
• [Presentation] Impact of onset-to-door time on clinical outcomes in patients with acute ischemic stroke: the Fukuoka Stroke Registry (2017)
  • Author(s): Matsuo R, Yamaguchi Y, Matsushita T, Fukuda K, Kiyuna F, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T
  • Organizer: 3rd European Stroke Organisation Conference
  • Int'l Joint Research
• [Presentation] 発症から来院までの時間が急性期脳梗塞患者の転帰に与える影響：Fukuoka Stroke Registry． (2017)
  • Author(s): 松尾 龍, 山口祐子, 松下知永，福田賢治，喜友名扶弥，脇坂義信, 黒田淳哉, 吾郷哲朗, 鴨打正浩, 北園孝成．
  • Organizer: 第4回日本心血管脳卒中学会総会
• [Presentation] 非弁膜症性心房細動合併脳梗塞患者における抗凝固療法：Fukuoka Stroke Registry． (2017)
  • Author(s): 黒田淳哉、吾郷哲朗、松尾 龍、脇坂義信、鴨打正浩、北園孝成．
  • Organizer: 第4回日本心血管脳卒中学会総会
• [Presentation] FSRからみた未破裂脳動脈瘤を合併した脳梗塞患者の予後． (2017)
  • Author(s): 鴨打正浩、生野雄二、松尾 龍、杉森 宏、吾郷哲朗、北園孝成．
  • Organizer: 第26回 日本脳ドック学会総会
• [Presentation] 急性期脳梗塞患者における“未破裂脳動脈瘤と抗血栓療法の実態”―FSRから． (2017)
  • Author(s): 吾郷哲朗、生野雄二、杉森 宏、松尾 龍、脇坂義信、黒田淳哉、鴨打正浩、北園孝成．
  • Organizer: 第26回 日本脳ドック学会総会
• [Presentation] FSRからみた心房細動患者における抗凝固療法の現状と認知症の影響について． (2017)
  • Author(s): 黒田淳哉
  • Organizer: 第26回 日本脳ドック学会総会
• [Presentation] 認知症を合併した脳梗塞患者の病態と機能転帰：Fukuoka Stroke Registry． (2017)
  • Author(s): 脇坂義信、松尾 龍、黒田淳哉、吾郷哲朗、鴨打正浩、北園孝成．
  • Organizer: 第26回 日本脳ドック学会総会
• [Presentation] 未破裂脳動脈瘤を合併した脳梗塞患者の長期予後：Fukuoka Stroke Registry． (2017)
  • Author(s): 生野雄二、松尾 龍、杉森 宏、脇坂義信、黒田淳哉、吾郷哲朗、鴨打正浩、北園孝成．
  • Organizer: 第26回 日本脳ドック学会総会
• [Presentation] Short-term exposure to fine particulate matter increased hospital admissions for ischaemic stroke in Japan (2017)
  • Author(s): Michikawa T; Matuso R; Ueda K; Ago T; Nitta H; Kitazono T; Kamouchi M; On behalf of the Fukuoka Stroke Registry Investigators
  • Organizer: the 29th Annual Scientific Conference of the International Society of Environmental Epidemiology
  • Int'l Joint Research
• [Presentation] 急性期脳梗塞患者における早期受診の効果～Fukuoka Stroke Registry (2017)
  • Author(s): 松尾 龍，脇坂義信, 黒田淳哉，吾郷哲朗，鴨打正浩，北園孝成
  • Organizer: 第1回日本臨床疫学学会総会
• [Presentation] Influence of pre-stroke cholinesterase inhibitor treatment on short-term functional outcome in acute ischemic stroke patients with pre-stroke dementia: the Fukuoka Stroke Registry (2017)
  • Author(s): Wakisaka Y, Matsuo R, Kuroda J, Ago T, Kamouchi M, Kitazono T
  • Organizer: the 8th Korea-Japan Stroke Conference
  • Int'l Joint Research
• [Presentation] Thrombolytic Therapy for Acute Ischemic Stroke Caused by Intracranial Artery Dissection: Fukuoka Stroke Registry (2017)
  • Author(s): Arakawa S, Osaki M, Sakai S, Kimura S, Hidaka M, Fukuta Y, Ago T, Kitazono T
  • Organizer: Asian Pacific Stroke Conference 2017
  • Int'l Joint Research
• [Presentation] Prognosis in Mild or Rapidly Improving Ischemic Stroke Not Treated with Recombinant Tissue Plasminogen Activator: Fukuoka Stroke Registry (2017)
  • Author(s): Sakai S, Osaki M, Kimura S, Hidaka M, Arakawa S, Ago T, Matsuo R, Kamouchi M, Kitazono T
  • Organizer: Asian Pacific Stroke Conference 2017
  • Int'l Joint Research
• [Presentation] Informed consent in a multicenter stroke registry: Fukuoka Stroke Registry. (2016)
  • Author(s): Noichi Y, Matsuo R, Kamouchi M, Furukawa S, Kitamura T, Ito Y, Murao K, Arakawa S, Ago T, Kitazono T.
  • Organizer: Asian-pacific Stroke conference 2017
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2016-07-14
  • Int'l Joint Research
• [Presentation] Association between neurological symptoms at stroke onset and use of ambulance. the Fukuoka Stroke Registry. (2016)
  • Author(s): Matsuo R, Yamaguchi Y, Kamouchi M, Sugimori H, Shono Y, Ago T, Kitazono T.
  • Organizer: Asian-pacific Stroke conference 2017
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2016-07-14
  • Int'l Joint Research
• [Presentation] Association between high-sensitivity CRP at stroke onset and clinical outcomes in patients with small vessel occlusion. (2016)
  • Author(s): iyuna F, Matsuo R, Wakisaka Y, Kuroda J, Ago T, Kamouchi M, Kitazono T; on behalf of the FSR investigators.
  • Organizer: European Stroke organization conference 2017
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2016-05-12
  • Int'l Joint Research
• [Presentation] Cardiovascular outcomes in patients with minor ischaemic stroke or high-risk transient ischaemic attack in Japan: the Fukuoka Stroke Registry. (2016)
  • Author(s): Matsuo R, Kamouchi M, Kiyuna F, Ago T, Kitazono T; on behalf of the FSR Investigators.
  • Organizer: European Stroke organization conference 2017
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2016-05-12
  • Int'l Joint Research