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Omics of sCD14 related innate immune system disturbance due to ethanol

Research Project

Project/Area Number 15K08871
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionOsaka University

Principal Investigator

Katada Ryuichi  大阪大学, 医学系研究科, 特任准教授(常勤) (00423757)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアルコール / 敗血症 / sCD14 / プレセプシン / sCD14 / 浮腫
Outline of Final Research Achievements

The mean of blood soluble sCD14 subtype (presepsin) in autopsy was higher than the clinical standard value. Presepsin was low in drowning and suffocation cases, and multiple injuries and blood loss cases. On the other hand, it was high in head injury and infection cases. The presepsin was useful for the differentiation of the cause of death and was shown to be useful for estimate of the hospitalization days. The association for alcohol and presepsin was not clear as alcohol concentration in sepsis and the infectious disease cases was not detected in blood. In addition, whole genome sequence from the infection nest organization was performed, which identified new toxicity species of bacteria and showed possibility to help the cause of death diagnosis.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016 2015 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (14 results) (of which Int'l Joint Research: 1 results) Remarks (3 results)

  • [Journal Article] A case of severe soft tissue infection due to Streptococcus tigurinus diagnosed by necropsy in which genomic analysis was useful for clarifying its pathogenicity2018

    • Author(s)
      Yoshizawa H, Motooka D, Katada R, Matsumoto Y, Nakamura S, Morii E, Iida T, Matsumoto H
    • Journal Title

      Pathology International

      Volume: 1 Pages: 1-6

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Whole-genome sequence of Streptococcus tigurinus strain osk_001, isolated from the postmortem material2017

    • Author(s)
      2.Yoshizawa H, Motooka D, Katada R, Matsumoto Y, Nakamura S, Morii E, Iida T, Matsumoto H
    • Journal Title

      Genome Announc

      Volume: 5

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] A new course for the cause of death investigation in the graduate school of medicine2017

    • Author(s)
      Matsumoto H, Ishida T, Yoshizawa H, Nakama K, Fujimoto H, Sugimoto K, Katada R
    • Organizer
      The 10th International Symposium ADVANCES IN LEGAL MEDICINE
    • Related Report
      2017 Annual Research Report
  • [Presentation] Molecular mechanisms of Wischnewski spot under hypothermia: an experimental study in rats2017

    • Author(s)
      Yang C, Sugimoto K, Hirata Y, Kamakura Y, Katada R, Matsumoto H
    • Organizer
      The 10th International Symposium ADVANCES IN LEGAL MEDICINE
    • Related Report
      2017 Annual Research Report
  • [Presentation] Prevention of stroke-related death: an experimental study on one protective mechanism of oxytocin for injured neurons in the rat stroke model2017

    • Author(s)
      Sugimoto K, Yang C, Hirata Y, Kamakura Y, Katada R, Matsumoto H
    • Organizer
      The 10th International Symposium ADVANCES IN LEGAL MEDICINE
    • Related Report
      2017 Annual Research Report
  • [Presentation] Heat stress changes Cx43 disposition, leading to develop arrhythmia2017

    • Author(s)
      Hirata Y, Sugimoto K, Yang C, Kamakura Y, Katada R, Matsumoto H
    • Organizer
      The 10th International Symposium ADVANCES IN LEGAL MEDICINE
    • Related Report
      2017 Annual Research Report
  • [Presentation] Streptococcus tigurinusによる重症軟部組織感染症の1例2017

    • Author(s)
      吉澤秀憲,片田竜一,元岡大祐,松本悠希,中村昇太,松本博志
    • Organizer
      第64回日本法医学会学術近畿地方集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 重症軟部組織感染症に対し起炎菌同定を行った一例2017

    • Author(s)
      吉澤秀憲,片田竜一,元岡大祐,中間健太郎,石田季子,中村昇太,松本博志
    • Organizer
      第101 次日本法医学会学術全国集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Streptococcus tigurinus による軟部組織感染症に対しネクロプシーを行った一例2017

    • Author(s)
      吉澤秀憲,元岡大祐,片田竜一,中村昇太,森井英一,松本博志
    • Organizer
      第106回日本病理学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] sCD14の感染死に及ぼす影響2016

    • Author(s)
      片田竜一,杉本香奈,中間健太郎,吉澤秀憲,藤本秀子,松本博志
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      きゅりあん(東京都)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット脳におけるイオンチャンネルの発現量に及ぼすエタノールの影響2016

    • Author(s)
      杉本香奈,片田竜一,田中秀和,平田雄一郎,鎌倉悠宇,吉田原規,高橋真樹子,望月薫,五十嵐一雄,松本博志
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      きゅりあん(東京都)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Effects of heat stress on the immune system in organotypic brain slice cultures2016

    • Author(s)
      鎌倉悠宇,杉本香奈,平田雄一郎,吉田原規,片田竜一,松本博志
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      きゅりあん(東京都)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Effects of heat stress on the conduction system in neonatal rat cardiomyocytes2016

    • Author(s)
      平田雄一郎,杉本香奈,鎌倉悠宇,吉田原規,片田竜一,松本博志
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      きゅりあん(東京都)
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Presentation] The effect of NKCC1 on aquaporin-4 induced astrocyte swelling2015

    • Author(s)
      Katada R, Sugimoto K, Nakama K, Yoshizawa H, Matsumoto H
    • Organizer
      Neuroscience2015
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      2015-11-17
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] エタノール及びNaによる水チャンネル発現変化に及ぼすαシントロフィンの影響2015

    • Author(s)
      片田竜一,杉本香奈,中間健太郎,吉澤秀憲,松本博志
    • Organizer
      平成27年度アルコール・薬物依存関連学会合同学術総会
    • Place of Presentation
      神戸国際会議場(兵庫県)
    • Year and Date
      2015-10-11
    • Related Report
      2015 Research-status Report
  • [Presentation] Na異常による脳浮腫形成に及ぼすAQP4とNKCC1の役割2015

    • Author(s)
      片田竜一,杉本香奈,中間健太郎,吉澤秀憲,松本博志
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市文化プラザかるぽーと(高知県)
    • Year and Date
      2015-06-11
    • Related Report
      2015 Research-status Report
  • [Remarks] 大阪大学法医学教室

    • URL

      http://www.legal.med.osaka-u.ac.jp/

    • Related Report
      2017 Annual Research Report
  • [Remarks] 大阪大学大学院医学系研究科法医学教室ホームページ

    • URL

      http://www.legal.med.osaka-u.ac.jp/

    • Related Report
      2016 Research-status Report
  • [Remarks] http://www.legal.med.osaka-u.ac.jp/

    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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