| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The goal of this study was to consider whether formalin-fixed human tissues for pathological examination were useful as substitutes for conventional specimens in toxicological analysis. As a first step, we developed UPLC-MS/MS analytical methods to simultaneous analysis for 60 drugs. Some psychotropic drugs were markedly depleted to varying degrees in formalin-fixed porcine liver homogenates. In forensic practice case, the drug was detected in formalin-fixed tissues, only if the concentration of the drug in blood was significantly high. It was suggested that in forensic practice formalin-fixed organs was partially useful for toxicological examination.
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