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Changes of plasma lipid mediators in antipsychotics related pulmonary arterial thromboembolism.

Research Project

Project/Area Number 15K08877
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionKumamoto University

Principal Investigator

Yonemitsu Kosei  熊本大学, 大学院生命科学研究部(医), 准教授 (10128332)

Co-Investigator(Renkei-kenkyūsha) NISHITANI Yoko  熊本大学, 大学院生命科学研究部(医), 教授 (30359997)
SASAO Ako  熊本大学, 大学院生命科学研究部(医), 助教 (80284751)
OHTSU Yuki  熊本大学, 大学院生命科学研究部(医), 専門技術職員 (90404342)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords肺動脈血栓塞栓症 / 抗精神病薬 / 脂質メディエーター / LC-MS/MS / 法医解剖 / アラキドン酸カスケード
Outline of Final Research Achievements

To elucidate the pathogenesis of pulmonary arterial thromboembolism occurring in patients taking antipsychotics, plasma lipid mediators (LMs) involved in thrombus formation were analyzed by LC-MS/MS using clozapine (an atypical antipsyhotics) administered rats. An extremely large individual difference was observed in TXB2 level, and no significant difference was observed between the clozapine and the control group. 6-keto-PGF1α level was under the lowest limit of quantification.In histopathological examination of forensic autopsy cases of pulmonary arterial thromboembolism during antipsychotic medication, fresh thrombus, organized thrombus and both mixed cases were observed. Preventive measures against thrombus formation during hospitalization are necessary for patients taking antipsychotics.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 2015

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (18 results)

  • [Journal Article] Liquid chromatography-tandem mass spectrometry detection of benzalkonium chloride (BZK) in a forensic autopsy case with survival for 18 days post BZK ingestion.2018

    • Author(s)
      Mishima-Kimura S, Yonemitsu K, Ohtsu Y, Sasao A, Tsutsumi H, Furukawa S, Nishitani Y
    • Journal Title

      Legal Medicine

      Volume: 32 Pages: 48-51

    • DOI

      10.1016/j.legalmed.2018.02.006

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of immunoassay for fluvoxamine detection using recombinant single-chain variable fragment antibody2017

    • Author(s)
      Ako Sasao, Michiyo Takaki, Yuki Ohtsu, Satoko Mishima, Kosei Yonemitsu, Hiroshi Morioka, Yoko Nishitani
    • Journal Title

      Forensic Toxicology

      Volume: 印刷中 Issue: 2 Pages: 301-308

    • DOI

      10.1007/s11419-017-0358-9

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A fatal poisoning case by intravenous injection of "bath salts" containing acetyl fentanyl and 4-methoxy PV8.2016

    • Author(s)
      Yonemitsu K, Sasao A, Mishima S, Ohtsu Y, Nishitani Y
    • Journal Title

      Forensic Science International

      Volume: epub ahead Pages: e6-e9

    • DOI

      10.1016/j.forsciint.2016.08.025

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Quantitative determination of n-butane metabolites in three cases of butane sniffing death2015

    • Author(s)
      Sasao A, Yonemitsu K, Ohtsu Y, Mishima S, Nishitani Y
    • Journal Title

      Forensic Science International

      Volume: 254 Pages: 180-184

    • DOI

      10.1016/j.forsciint.2015.07.032

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Detection of carbon monoxide poisoning that occured before a house fire in three cases2015

    • Author(s)
      Oshima T, Yonemitsu K, Sasao A, Ohtani M, Mimasaka Sohtaro
    • Journal Title

      Legal Medicine

      Volume: 17 Issue: 5 Pages: 371-375

    • DOI

      10.1016/j.legalmed.2015.05.003

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 揮発性有機化合物検査から一家心中が疑われた焼死事案2015

    • Author(s)
      大島徹、笹尾亜子、米満孝聖、大谷真紀、美作宗太郎
    • Journal Title

      法医学の実際と研究

      Volume: 58 Pages: 41-45

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Presentation] High mirtazapine concentration in a newborn baby - A child abuse case -2018

    • Author(s)
      Kosei Yonemitsu, Ako Sasao, Yuki Ohtsu, Hiroshi Tsutsumi, Shota Furukawa, Satoko Mishima, Yoko Nishitani
    • Organizer
      The 24th Congress of the International Academy of Legal Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of a Fluvoxamine Detection System Using Quenchbody, a Novel Antibody-Based Fluorescent Biosensor2018

    • Author(s)
      Ako Sasao, Michiyo Takaki, Kyoko Hirata, Yuki Ohtsu, Hiroshi Tsutsumi, Shota Furukawa, Kosei Yonemitsu, Hiroshi Morioka, Hiroshi Ueda, Yoko Nishitani
    • Organizer
      The 24th Congress of the International Academy of Legal Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of neuropsychiatric drugs on neurotransmitters level in the rat cerebrospinal fluid.2018

    • Author(s)
      Hiroshi Tsutsumi, Kosei Yonemitsu, Ako Sasao, Yuki Ohtsu, Shota Furukawa, Satoko Mishima, Yoko Nishitani
    • Organizer
      The 24th Congress of the International Academy of Legal Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] A sudden death related to 1,1-Difluoroethane (HFC-152a, DFE) inhalation.2018

    • Author(s)
      Kyoko Hirata, Ako Sasao, Kosei Yonemitsu, Yuki Ohtsu, Hiroshi Tsutsumi, Shota Furukawa, Satoko Mishima,Yoko Nishitani
    • Organizer
      The 24th Congress of the International Academy of Legal Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] Effects of arterial bleeding on blood coagulation/fibrinolysis-system in rats - A preliminary study2018

    • Author(s)
      Shota Furukawa, Ako Sasao, Kosei Yonemitsu, Yuki Ohtsu, Hiroshi Tsutsumi, Satoko Mishima, Kazuaki Taguchi, Yoko Nishitani
    • Organizer
      The 24th Congress of the International Academy of Legal Medicine
    • Related Report
      2017 Annual Research Report
  • [Presentation] 焼損臓器等を試料とした焼死体の揮発性有機化合物分析2017

    • Author(s)
      米満孝聖, 大津由紀, 笹尾亜子, 堤 博志, 古川翔太, 三島聡子, 西谷陽子
    • Organizer
      第101次日本法医学会学術全国集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 抗うつ薬フルボキサミンの一本鎖抗体を用いたELISA定量法とその特性2017

    • Author(s)
      笹尾亜子, 髙木美智代, 大津由紀, 三島聡子, 堤 博志, 古川翔太, 米満孝聖, 森岡弘志, 西谷陽子
    • Organizer
      第101次日本法医学会学術全国集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Gemella morbillorum による肺膿瘍の1例2017

    • Author(s)
      西谷陽子,堤 博志,古川翔太,大津由紀,笹尾亜子,木村聡子,米満孝聖
    • Organizer
      第67回日本法医学会学術九州地方集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 血漿中脂質メディエーターのLC-MS/MS分析2017

    • Author(s)
      米満孝聖,笹尾亜子,大津由紀,堤 博志,古川翔太,木村聡子,西谷陽子
    • Organizer
      第67回日本法医学会学術九州地方集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] エタノールと共に検出される腐敗性アルコール類のGC-MS分析2016

    • Author(s)
      米満孝聖, 大津由紀, 笹尾亜子, 堤 博志, 古川翔太, 三島聡子, 西谷陽子
    • Organizer
      第66回日本法医学会学術九州地方集会
    • Place of Presentation
      久留米市
    • Year and Date
      2016-10-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 塩化ベンザルコニウム誤飲18日後に死亡した1事例2016

    • Author(s)
      三島聡子, 大津由紀, 笹尾亜子, 米満孝聖, 西谷陽子
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      東京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Presentation] 抗うつ薬フルボキサミンに対する蛍光免疫測定素子Quenchbodyの作製2016

    • Author(s)
      笹尾亜子、髙木美智代、Hee-Jin Jeong、大津由紀、三島聡子、米満孝聖、上田宏、西谷陽子
    • Organizer
      第100次日本法医学会学術全国集会
    • Place of Presentation
      東京都
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Hirschsprung病の既往のある小児の突然死事例2015

    • Author(s)
      西谷陽子、三島聡子、堤博志、古川翔太、大津由紀、笹尾亜子、米満孝聖
    • Organizer
      第65回日本法医学会九州地方集会
    • Place of Presentation
      宮崎市
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] LC-MSMSを用いた塩化ベンザルコニウムの分析2015

    • Author(s)
      米満孝聖、大津由紀、笹尾亜子、三島聡子、堤博志、古川翔太、西谷陽子
    • Organizer
      第65回日本法医学会九州地方集会
    • Place of Presentation
      宮崎市
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 揮発性有機化合物検査から一家心中が疑われた焼死事案2015

    • Author(s)
      大島徹、笹尾亜子、米満孝聖、大谷真紀、美作宗太郎
    • Organizer
      第65回日本法医学会九州地方集会
    • Place of Presentation
      宮崎市
    • Year and Date
      2015-10-16
    • Related Report
      2015 Research-status Report
  • [Presentation] 肝細胞におけるエタノール代謝と脂質代謝の関係2015

    • Author(s)
      西谷陽子、三島聡子、古川翔太、堤博志、笹尾亜子、米満孝聖
    • Organizer
      日本アルコール・薬物医学会雑誌
    • Place of Presentation
      神戸市
    • Year and Date
      2015-10-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 薬毒物スクリーニングにおける遺伝子工学的技術の応用-抗うつ薬フルボキサミンに対する一本鎖抗体の調製とその特性-2015

    • Author(s)
      笹尾亜子、髙木美智代、大津由紀、三島聡子、米満孝聖、森岡弘志、西谷陽子
    • Organizer
      日本プロテオーム学会2015年会
    • Place of Presentation
      熊本市
    • Year and Date
      2015-07-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 抗うつ薬フルボキサミンに対する一本鎖抗体の調製とその特性2015

    • Author(s)
      笹尾亜子、髙木美智代、大津由紀、三島聡子、米満孝聖、森岡弘志、西谷陽子
    • Organizer
      第99次日本法医学会学術全国集会
    • Place of Presentation
      高知市
    • Year and Date
      2015-06-10
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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