Elucidation of intrathrombotic mechanism of autophagic functions in the deep vein thrombosis formation and its application to forensic medicine

• Project/Area Number: 15K08880
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Legal medicine
• Research Institution: Wakayama Medical University
• Principal Investigator: Nosaka Mizuho 和歌山県立医科大学, 医学部, 助教 (00244731)
• Co-Investigator(Kenkyū-buntansha): 近藤 稔和 和歌山県立医科大学, 医学部, 教授 (70251923) ; 木村 章彦 和歌山県立医科大学, 医学部, 博士研究員 (60136611) ; 石田 裕子 和歌山県立医科大学, 医学部, 講師 (10364077)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 深部静脈血栓塞栓症 / 血栓陳旧度 / オートファジー / p62 / LC3 / 深部静脈血栓症 / サイトカイン / マクロファージ

Outline of Final Research Achievements

Deep vein thrombosis (DVT) is multifactorial and often results from a combination of risk factors such as obesity, pregnancy, aging and malignancy. Eight-week-old male wild type mice were employed in this study. DVT was induced by the ligation of inferior vena cava. At 1, 3, 5, 7, 10, 14 and 21 days, immunohistochemical analyses were performed. In the murine thrombi, the LC3- or p62-positive cells were detected. The LC3-positive cells were observed all thrombus samples (n=5 per group). But in the thrombus age of 1 day, p62-positive cells were not detected and p62/LC3 ratios were nearly zero. After 3 days, p62-positive cells were detected, and p62/LC3 ratios were over 1.0. At 14 days, there were much p62-positive cells exceeded LC3+ cells, and p62/LC3 ratios reached over 2.0. Our observations indicated the detection of intrathrombotic LC3 and p62 could be a useful marker for thrombus age determination.

Research Products

• [Journal Article] Protective Roles of Interferon-γ in Cardiac Hypertrophy Induced by Sustained Pressure Overload (2018)
  • Author(s): Kimura A, Ishida Y, Furuta M, Nosaka M, Kuninaka Y, Taruya A, Mukaida N, Kondo T
  • Journal Title: J Am Heart Assoc Volume: 7(6) Issue: 6
  • DOI: 10.1161/jaha.117.008145
  • Peer Reviewed / Open Access
• [Journal Article] Fatal acute intoxication of accidentally ingested nifedipine in an infant - A case report (2017)
  • Author(s): Yamamoto H
  • Journal Title: Leg Med (Tokyo) Volume: 24 Pages: 12-18
  • DOI: 10.1016/j.legalmed.2016.11.002
  • Peer Reviewed / Open Access
• [Journal Article] Ventricular androgenic-anabolic steroid-related remodeling: an immunohistochemical study (2017)
  • Author(s): Cecchi R, Muciaccia B, Ciallella C, Di Luca NM, Kimura A, Sestili C, Nosaka M, Kondo T
  • Journal Title: Int J Legal Med Volume: 131(6) Issue: 6 Pages: 1589-1595
  • DOI: 10.1007/s00414-017-1589-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Detection of intrathrombotic endothelial progenitor cells and its application (2017)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Yamamoto H, Kato T, Kuninaka Y, Shimada E, Kondo
  • Journal Title: International Journal of Legal Medicine Volume: 131 Issue: 6 Pages: 1633-1638
  • DOI: 10.1007/s00414-017-1668-5
  • Peer Reviewed / Open Access
• [Journal Article] Severer lupus erythematosus-like skin lesions in MRL/lpr mice with homozygous Kitwsh/wsh mutation (2017)
  • Author(s): Inaba Yutaka、Kanazawa Nobuo、Yoshimasu Takashi、Shimokawa Toshio、Nosaka Mizuho、Kondo Toshikazu、Furukawa Fukumi
  • Journal Title: Modern Rheumatology Volume: 28 Issue: 2 Pages: 319-326
  • DOI: 10.1080/14397595.2017.1341591
  • Peer Reviewed / Open Access
• [Journal Article] Postmortem distribution of chlorpyrifos-methyl, fenitrothion, and their metabolites in body fluids and organ tissues of an intoxication case (2017)
  • Author(s): Takayasu T, Yamamoto H, Ishida Y, Nosaka M, Kawaguchi M, Kuninaka Y, Kimura A, Kondo T
  • Journal Title: Legal Medicine Volume: 29 Pages: 44-50
  • DOI: 10.1016/j.legalmed.2017.10.002
  • Peer Reviewed / Open Access
• [Journal Article] Essential involvement of the CX3CL1-CX3CR1 axis in bleomycin-induced pulmonary fibrosis via regulation of fibrocyte and M2 macrophage migration. (2017)
  • Author(s): 4.Y. Ishida, A. Kimura, M. Nosaka, Y. Kuninaka, H. Hemmi, I. Sasaki, T. Kaisho, N. Mukaida, T. Kondo.
  • Journal Title: Sci Rep Volume: 7 Issue: 1 Pages: 16833-16833
  • DOI: 10.1038/s41598-017-17007-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Influence of circadian rhythm on thrombus formation of murine deep vein thrombosis model (2017)
  • Author(s): Kondo他9名
  • Journal Title: Annals of Hematology & Oncology Volume: 4 Issue: 9 Pages: 1171-1171
  • DOI: 10.26420/annhematoloncol.2017.1171
  • Peer Reviewed / Open Access
• [Journal Article] The effect of hydroxychloroquine on lupus erythematosus-like skin lesions in MRL/lpr mice (2016)
  • Author(s): Shimomatsu T
  • Journal Title: Mod Rheumatol Volume: 26 Issue: 5 Pages: 744-748
  • DOI: 10.3109/14397595.2016.1140711
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistochemical detection of intrathrombotic fibrocytes and its application to thrombus age estimation in murine deep vein thrombosis model (2016)
  • Author(s): Nosaka M
  • Journal Title: Int J Legal Med Volume: 131 Issue: 1 Pages: 179-183
  • DOI: 10.1007/s00414-016-1465-6
  • Peer Reviewed / Open Access
• [Journal Article] Exaggerated arsenic nephrotoxicity in female mice through estrogen-dependent impairments in the autophagic flux. (2016)
  • Author(s): Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Hama M, Kawaguchi T, Sakamoto S, Shinozaki K, Iwahashi Y, Takayasu T, Kondo T.
  • Journal Title: Toxicology. Volume: 339 Pages: 9-18
  • DOI: 10.1016/j.tox.2015.11.005
  • Peer Reviewed
• [Journal Article] Immunohistochemical detection of intrathrombotic IL-6 and its application to thrombus age estimation (2015)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Hama M, Kawaguchi T, Yamamoto H, Kuninaka Y, Shimada E, Kondo T
  • Journal Title: Int J Legal Med Volume: - Issue: 5 Pages: 1021-1025
  • DOI: 10.1007/s00414-015-1147-9
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autophagy in skin wounds: a novel marker for vital reactions (2015)
  • Author(s): Kimura A, Ishida Y, Nosaka M, Shiraki M, Hama M, Kawaguchi T, Kuninaka Y, Shimada E, Yamamoto H, Takayasu T, Kondo T.
  • Journal Title: Int J Legal Med Volume: - Issue: 3 Pages: 537-541
  • DOI: 10.1007/s00414-015-1168-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immunohistochemical analysis on MMP-2 and MMP-9 for wound age determination (2015)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Kawaguchi T, Hama M, Sakamoto S, Shinozaki K, Eisenmenger W, Kondo T.
  • Journal Title: Int J Legal Med Volume: - Issue: 5 Pages: 1043-1048
  • DOI: 10.1007/s00414-015-1167-5
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Detection of endothelial progenitor cells in human skin wounds and its application for wound age determination. (2015)
  • Author(s): Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Shimada E, Yamamoto H, Nishiyama K, Inaka S, Takayasu T, Eisenmenger W, Kondo T.
  • Journal Title: Int J Legal Med. Volume: 129(5) Issue: 5 Pages: 1049-54
  • DOI: 10.1007/s00414-015-1181-7
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] AG490, a Jak2 inhibitor, suppressed the progression of murine ovarian cancer. (2015)
  • Author(s): Kobayashi A, Tanizaki Y, Kimura A, Ishida Y, Nosaka M, Toujima S, Kuninaka Y, Minami S, Ino K, Kondo T.
  • Journal Title: Eur. J. Pharmacol. Volume: 766 Pages: 63-75
  • DOI: 10.1016/j.ejphar.2015.09.039
  • Peer Reviewed / Open Access
• [Presentation] アジ化物による中毒死の1剖検例 (2017)
  • Author(s): 山本寛記，工藤恵子，木村章彦，野坂みずほ，石田裕子，川口敬士，近藤稔和
  • Organizer: 第37回日本中毒学会西日本地方会
• [Presentation] 卵巣癌の進展におけるケモカイン受容体CCR5の病態生理学的役割 (2017)
  • Author(s): 近藤稔和，小林彩，佐々木宗一郎，石田裕子，野坂みずほ，木村章彦，井箟一彦，向田直史
  • Organizer: 金沢大学がん進展制御研究所共同利用・共同研究拠点シンポジウム
• [Presentation] Autophagy in skin wounds: a novel marker for vital reactions (2017)
  • Author(s): Kondo T, Kimura A, Ishida Y, Nosaka M, Kuninaka Y, E Shimada, Kawaguchi M, H.Yamamoto
  • Organizer: 26th Spring Meeting of German Society of Legal Medicine in North
• [Presentation] The absence of Spi-B exaggerates acute aortic dissection in mice (2017)
  • Author(s): 樽谷 玲，木村章彦，石田裕子，野坂みずほ，國中由美，島田栄美，山本寛記，川口真理子，近藤稔和
  • Organizer: 第101次日本法医学会学術全国集会
• [Presentation] 深部静脈血栓におけるオートファジーと法医診断学的応用に関する研究 (2017)
  • Author(s): 野坂みずほ，石田裕子，山本寛記，木村章彦，國中由美，川口真理子，近藤稔和
  • Organizer: 第101次日本法医学会学術全国集会
• [Presentation] The influence of circadian rhythm on thrombus formation, infection and intoxication (2017)
  • Author(s): Kuninaka Y, Yamamoto H, Nosaka M, Ishida Y, Shimada E, Kawaguchi M, Kimura A, Kondo T
  • Organizer: 第101次日本法医学会学術全国集会
• [Presentation] ジルチアゼム，プロプラノロールやミルタザピンなどを大量に服用し死亡した１事例 (2017)
  • Author(s): 高安達典，山本寛記，石田裕子，野坂みずほ，川口真理子，國中由美，木村章彦，近藤稔和
  • Organizer: 第101次日本法医学会学術全国集会
• [Presentation] Immunohistochemical detection of intrathrombotic endothelial progenitor cell and its application to thrombus age estimation in murine deep vein thrombosis model (2017)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Yamamoto H, Shimada E, Kondo T
  • Organizer: 26. Frhjahrstauuugung der Deutschen Gesellschaft fr Rechtsmedizin (Region Sd) in Verbindung mit dem 47. Treffen der Oberrheinischen Rechtsmediziner
  • Int'l Joint Research
• [Presentation] Fatal acute intoxication of accidentally ingested nifedipine in an infant (2017)
  • Author(s): Yamamoto H, Takayasu T, Ishida Y, Nosaka M, Kimura A, Shimada E, Kondo T
  • Organizer: 26. Fruhjahrstagung der Deutschen Gesellschaft fur Rechtsmedizin (Region Sud) in Verbindung mit dem 47. Treffen der Oberrheinischen Rechtsmediziner
  • Int'l Joint Research
• [Presentation] Immunohistochemical study on thrombus age determination (2017)
  • Author(s): Nosaka M
  • Organizer: The Seminar for the Post-graduate Course of Legal Medicine
  • Invited
• [Presentation] Spi-Bは圧負荷による心不全の病態形成において炎症と線維化を抑制して保護的に機能する (2017)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，佐々木 泉，山本寛記，國中由美，加藤 喬，福田有里，改正恒康，近藤稔和
  • Organizer: 第38回日本炎症・再生医学会
• [Presentation] The absence of CCL3 exaggerated CaCl2-induced aortic aneurysm (2017)
  • Author(s): 石田裕子，國中由美，野坂みずほ，木村章彦，向田直史，近藤稔和
  • Organizer: 第38回日本炎症・再生医学会
• [Presentation] 深部静脈血栓症モデルにおけるCCR5システムの病態生理学的役割の解明 (2017)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，山本寛記，國中由美，向田直史，近藤稔和
  • Organizer: 第38回日本炎症・再生医学会
• [Presentation] Molecular Pathophysiological Study on Thrombus Age Determination (2017)
  • Author(s): Nosaka M
  • Organizer: The 1st Wakayama Medical University International Symposium of Forensic Molecular Pathology
• [Presentation] いわゆる「ペットボトル症候群」による突然死の１剖検例 (2017)
  • Author(s): 秦 聡，岡田美里，奥本航平，北村謙伍，野坂みずほ，石田裕子，山本寛記，國中由美，島田栄美，木村章彦，近藤稔和
  • Organizer: 第２４回法医病理セミナー
• [Presentation] Forensic diagnosis of compression based on expression of aquaporin-3 in human neck skin (2017)
  • Author(s): Kondo T, Ishida Y, Nosaka M, Kimura A, Kuninaka Y, Yamamoto H, Kawaguchi M, Shimada E, Hata S
  • Organizer: 10th International Symposium Advances in Legal Medicine
  • Int'l Joint Research
• [Presentation] A retrospective study on forensic autopsy ceases of elder persons in Wakayama prefecture (2017)
  • Author(s): Hashizume Y, Hata S, Yamamoto H, Shimada E, Kuninaka Y, Kawaguchi M, .Ishida Y, Nosaka M, Kimura A, Takatsu A, Kondo T
  • Organizer: 10th International Symposium Advances in Legal Medicine
  • Int'l Joint Research
• [Presentation] The influence of circadian rhythm on thrombus formation, infection and intoxication (2017)
  • Author(s): Ishida Y, Kuninaka Y, Hata S, Nosaka M, Kimura A, Yamamoto H, Shimada E, .Kawaguchi M, Murakami K, Sakamoto S, Kondo T
  • Organizer: 10th International Symposium Advances in Legal Medicine
  • Int'l Joint Research
• [Presentation] Acetaminophen-induced fulminant hepatic failure altered the biological clock in mouse heart (2017)
  • Author(s): Kimura A, Yamamoto H, Ozaki M, Hata S, Ishida Y, Nosaka M, Kuninaka Y, Hashizume Y, Kondo T
  • Organizer: 10th International Symposium Advances in Legal Medicine
  • Int'l Joint Research
• [Presentation] Immunohistochemical detection of intrathrombotic fibrocytes and its application to .thrombus age estimation in murine deep vein thrombosis model (2017)
  • Author(s): Nosaka M, Ishida Y, Kuninaka Y, Yamamoto H, Shimada E, Kimura A, Hashizume Y, Kondo T
  • Organizer: 10th International Symposium Advances in Legal Medicine
  • Int'l Joint Research
• [Presentation] The absence of Spi-B exaggerates acute aortic dissection in mice (2017)
  • Author(s): Taruya A, Kimura A, Ishida Y, Nosaka M, Kondo T
  • Organizer: 10th International Symposium Advances in Legal Medicine
  • Int'l Joint Research
• [Presentation] The absence of CCL3 exaggerated CaCl2-induced aortic aneurysm (2017)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Yamamoto H, Shimada E, Kawaguchi M, Kondo T
  • Organizer: 10th International Symposium Advances in Legal Medicine
  • Int'l Joint Research
• [Presentation] Molecular toxicological study on the influence of circadian rhythms on acetaminophen hepatotoxicity (2017)
  • Author(s): Yamamoto H, Ishida Y, Nosaka M, Kuninaka Y, Shimada E, Kawaguchi M, Kimura A, Kondo T
  • Organizer: 10th International Symposium Advances in Legal Medicine
  • Int'l Joint Research
• [Presentation] Molecular Pathophysiological Study on Thrombus Age Determination. (2017)
  • Author(s): Nosaka M
  • Organizer: The 1st Wakayama Medical University International Symposium of Forensic Molecular Pathology
  • Int'l Joint Research / Invited
• [Presentation] Absence of CCR5 axis inhibits thrombus resolution through reduced uPA, tPA and VEGF expression in murine DVT model (2017)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Yamamoto H, Kuninaka Y, Shimada E, Mukaida N, Kondo T
  • Organizer: 5th Annual Meeting of the International Cytokine & Interferon Society
  • Int'l Joint Research
• [Presentation] The absence of CCL3 exaggerated CaCl2-induced aortic aneurysm (2017)
  • Author(s): Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Mukaida N, Kondo T
  • Organizer: 5th Annual Meeting of the International Cytokine & Interferon Society
  • Int'l Joint Research
• [Presentation] Prevention of lipopolysaccharide-induced preterm labor by the lack of CX3CL1-CX3CR1 interaction (2017)
  • Author(s): Mizoguchi M, Ishida Y, Nosaka M, Kimura A, Yahata T, Kuninaka Y, Nanjo S, Minami S, Ino K, Mukaida N, Kondo T
  • Organizer: 5th Annual Meeting of the International Cytokine & Interferon Society
  • Int'l Joint Research
• [Presentation] クエン酸と重曹の混合による若年者の自殺例 (2017)
  • Author(s): 村上圭秀，北村謙伍，岡田美里，奥本航平，石田裕子，野坂みずほ，國中由美，山本寛記，島田栄美，木村章彦，高津光洋，近藤稔和
  • Organizer: 第64回日本法医学会学術近畿地方集会
• [Presentation] 和歌山県の法医解剖例における高齢者事例の実態 (2017)
  • Author(s): 橋爪祐示子，秦 聡，北村謙伍，石田裕子，野坂みずほ，山本寛記，島田栄美，國中由美，川口真理子，村上圭秀，木村章彦，高津光洋，近藤稔和
  • Organizer: 第64回日本法医学会学術近畿地方集会
• [Presentation] CCL2は糖尿病マウスの創傷部に血管内皮前駆細胞浸潤を増加させて創傷治癒を促進する (2017)
  • Author(s): 石田裕子，國中由美，野坂みずほ，木村章彦，近藤稔和
  • Organizer: 第47回日本創傷治癒学会
• [Presentation] Absence of CCR5 axis exaggerates thrombus formation through reduced uPA, tPA and VEGF expression in murine DVT model (2017)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第46回日本免疫学会学術集会
• [Presentation] The absence of CCL3 exaggerates CaCl2-induced aortic aneurysm (2017)
  • Author(s): Kondo T, Ishida Y, Kuninaka Y, Nosaka M, Kimura A, Mukaida N
  • Organizer: 第46回日本免疫学会学術集会
• [Presentation] Decline of lysyl oxidase protein causes acute aortic dissection in Spi-B knockout mice (2017)
  • Author(s): Taruya A, Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Sasaki I, Kaisho T, Kondo T
  • Organizer: 第46回日本免疫学会学術集会
• [Presentation] ニフェジピン誤飲による中毒死の1剖検例 (2016)
  • Author(s): 山本寛記，高安達典，木村章彦，野坂みずほ，石田裕子，川口敬士，近藤稔和
  • Organizer: 第36回日本中毒学会西日本地方会
  • Place of Presentation: 国立病院機構大阪医療センター（大阪府大阪市）
  • Year and Date: 2016-02-06
• [Presentation] IFN-gamma plays protective roles in the pathogenesis of cardio-renal syndrome type 1 through the induction of intracardiac ANP expresstion (2016)
  • Author(s): Kimura A, Ishida Y, Nosaka M, Mukaida N, Kondo T
  • Organizer: Heart Failure 2016 － 3rd World Congress on Acute Heart Failure，Heart Failure
  • Place of Presentation: Florence (Italy)
  • Int'l Joint Research
• [Presentation] Absence of CCR5 axes accelerates thrombus formation through reduced uPA and tPA expression in murine deep vein thrombosis model (2016)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Mukaida N, Kondo T
  • Organizer: The 24th International Symposium on Molecular Cell Biology of Macrophages 2016 (MMCB2016)
  • Place of Presentation: ソラシティカンファレンスセンター （東京都千代田区）
  • Int'l Joint Research
• [Presentation] 深部静脈血栓症におけるEPCの動態と法医診断学的応用に関する研究 (2016)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，川口敬士，濵 瑞貴，篠﨑浩平，坂本翔一，國中由美，川口真理子，近藤稔和
  • Organizer: 第100次日本法医学会学術全国集会
  • Place of Presentation: きゅりあん （東京都品川区）
• [Presentation] The pathophysiological roles of CCL3 in CaCl2-induced aneurysm (2016)
  • Author(s): 石田裕子，國中由美，川口敬士，近藤稔和
  • Organizer: 第100次日本法医学会学術全国集会
  • Place of Presentation: きゅりあん （東京都品川区）
• [Presentation] IFN-γはANPの発現を介して1型心腎関連の病態形成において保護的に機能する (2016)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，國中由美，山本寛記，近藤稔和
  • Organizer: 第100次日本法医学会学術全国集会
  • Place of Presentation: きゅりあん （東京都品川区）
• [Presentation] クロルピリホスメチルおよびフェニトロチオンを同時に検出した1事例 (2016)
  • Author(s): 高安達典，山本寛記，石田裕子，野坂みずほ，川口真理子，國中由美，木村章彦，近藤稔和
  • Organizer: 第100次日本法医学会学術全国集会
  • Place of Presentation: きゅりあん （東京都品川区）
• [Presentation] New Molecular and Imaging Innovations in Forensic Pathology (2016)
  • Author(s): Kondo T
  • Organizer: IALM Intersocietal Symposium
  • Place of Presentation: Venice (Italy)
  • Int'l Joint Research
• [Presentation] The roles of autophagy in skin wound healing (2016)
  • Author(s): Kimura A, Nosaka M, Ishida Y, Yamanoto H, Kawaguchi T, Kuninaka Y, Furuta M, Kondo T
  • Organizer: IALM Intersocietal Symposium
  • Place of Presentation: Venice (Italy)
  • Int'l Joint Research
• [Presentation] Immunohistochemical detection of intrathrombotic fibrocytes and its application to thrombus age estimation in murine deep vein thrombosis model (2016)
  • Author(s): Nosaka M, Ishida Y, Kuninaka Y, Yamanoto H, Shimada E, Kawaguchi T, Kimura A, Kondo T
  • Organizer: IALM Intersocietal Symposium
  • Place of Presentation: Venice (Italy)
  • Int'l Joint Research
• [Presentation] Absence of CCR5 axis exaggerates thrombus formation through reduced uPA and tPA expression in murine DVT model (2016)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 16th International congress of Immunology
  • Place of Presentation: Melbourne (Australia)
  • Int'l Joint Research
• [Presentation] The influence of circadian rhythm on thrombus formation, infection and intoxication (2016)
  • Author(s): Kondo T, Nosaka M, Kimura A, Ishida Y, Kawaguchi T, Yamanoto H, Kawaguchi M
  • Organizer: 95.Jahrestagung der Deutschen Gesellschaft fur Rechtsmedizin
  • Place of Presentation: Heidelberg (Germany)
  • Int'l Joint Research
• [Presentation] ノーベル賞と法医学と私 (2016)
  • Author(s): 木村章彦
  • Organizer: 第63回日本法医学会学術近畿地方集会
  • Place of Presentation: 大阪大学中之島センター 佐治敬三メモリアルホール （大阪市北区）
  • Invited
• [Presentation] 和歌山県の法医解剖例における孤独死の実態 (2016)
  • Author(s): 橋爪佑示子，木村章彦，石田裕子，野坂みずほ，山本寛記，川口敬士，國中由美， 島田栄美，川口真理子，近藤稔和
  • Organizer: 第63回日本法医学会学術近畿地方集会
  • Place of Presentation: 大阪大学中之島センター 佐治敬三メモリアルホール （大阪市北区）
• [Presentation] Spi-B plays a protective role in pressure overload-induced heart failure through attenuation of cardiacinflammation (2016)
  • Author(s): Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Sasaki I, Fukuda Y, Kaisho T, Kondo T
  • Organizer: 第45回日本免疫学会総会学術集会
  • Place of Presentation: 沖縄コンベンションセンター （沖縄県宜野湾市）
• [Presentation] The absence of CX3CR1 impairs inflammation-induced preterm labor through the reduction of intrauterine macrophage recruitment (2016)
  • Author(s): Mizoguchi M, Nosaka M, Ishida Y, Kuninaka Y, Kimura A, Mukaida N, Kondo T.
  • Organizer: 第45回日本免疫学会総会学術集会
  • Place of Presentation: 沖縄コンベンションセンター （沖縄県宜野湾市）
• [Presentation] The absence of Spi-B exaggerates acute aortic dissection in mice (2016)
  • Author(s): Taruya A, Kimura A, Nosaka M, Ishida Y, Kuninaka Y, Sasaki I, Fukuda Y, Kaisho T, Kondo T
  • Organizer: 第45回日本免疫学会総会学術集会
  • Place of Presentation: 沖縄コンベンションセンター （沖縄県宜野湾市）
• [Presentation] 侵襲と組織修復－皮膚から心臓まで (2016)
  • Author(s): 近藤稔和
  • Organizer: 第46回日本創傷治癒学会
  • Place of Presentation: 東京大学伊藤国際学術研究センター／安田講堂 （東京都文京区）
• [Presentation] 深部静脈血栓症モデルにおけるCCR5システムの病態生理学的役割の解明（第２報） (2016)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，山本寛記，國中由美，近藤稔和
  • Organizer: 第46回日本創傷治癒学会
  • Place of Presentation: 東京大学伊藤国際学術研究センター／安田講堂 （東京都文京区）
• [Presentation] 皮膚創傷治癒におけるAkt/autophagy axisとKeap1/Nfr2相互作用の役割 (2016)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，山本寛記，國中由美，近藤稔和
  • Organizer: 第46回日本創傷治癒学会
  • Place of Presentation: 東京大学伊藤国際学術研究センター／安田講堂 （東京都文京区）
• [Presentation] 深部静脈血栓症モデルにおけるCCR5システムの病態生理学的役割の解明 (2015)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，國中由美，近藤稔和
  • Organizer: 第45回日本創傷治癒学会
  • Place of Presentation: JPタワーホール＆カンファレンス：JPタワー・KITTE （東京都千代田区）
  • Year and Date: 2015-11-30
• [Presentation] 皮膚創傷治癒におけるautophagyの役割 (2015)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，國中由美，近藤稔和
  • Organizer: 第45回日本創傷治癒学会
  • Place of Presentation: JPタワーホール＆カンファレンス：JPタワー・KITTE （東京都千代田区）
  • Year and Date: 2015-11-30
• [Presentation] Absence of CCR5 axis accelerates thrombus formation through reduced uPA and tPA expression in mice (2015)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2015-11-18
• [Presentation] Absence of CCR5 exaggerated pressure overload-induced heart failure (2015)
  • Author(s): Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2015-11-18
• [Presentation] Pivotal roles of CCR5 for the tumor progression in a mouse ovarian cancer (2015)
  • Author(s): Ishida Y, Kobayashi A, Sasaki S, Kimura A, Nosaka M, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: 第44回日本免疫学会学術集会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2015-11-18
• [Presentation] ケモカイン受容体CCR5を介したシグナルは圧負荷による心肥大において保護的に機能する (2015)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，國中由美，川口真理子，近藤稔和
  • Organizer: 第62回日本法医学会学術近畿地方集会
  • Place of Presentation: 京都教育文化センター（京都府京都市）
  • Year and Date: 2015-11-14
• [Presentation] Absence of CCR5 exaggerated pressure overload-induced heart failure in mice (2015)
  • Author(s): Kimura A, Ishida Y, Nosaka M, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: Cytokines 2015 －Symphonies in Health and Disease
  • Place of Presentation: Konzert- und Kongresshalle Bamberg, Bamberg (Germany)
  • Year and Date: 2015-10-12
  • Int'l Joint Research
• [Presentation] Absence of IL-6 impairs thrombus resolution through reduced MMPs and uPA expression in murine deep vein thrombosis model (2015)
  • Author(s): Nosaka M, Ishida Y, Kimura A, Kuninaka Y, Mukaida N, Kondo T
  • Organizer: Society of Leukocyte Biology
  • Place of Presentation: Hilton North Raleigh, Midtown, NC (USA)
  • Year and Date: 2015-09-29
  • Int'l Joint Research
• [Presentation] Forensic diagnosis of compression based on expression of aquaporin-3 but not aquaporin-1 in human neck skin (2015)
  • Author(s): Sakamoto S, Ishida Y, Kimura A, Nosaka M, Kuninaka Y, Kawaguchi M, Hama M, Kawaguchi T, Kondo T
  • Organizer: 94.Jahrestagung der Deutschen Gesellschaft fur Rechtsmedizin
  • Place of Presentation: Leipzig (Germany)
  • Year and Date: 2015-09-16
  • Int'l Joint Research
• [Presentation] ウォータージェットによる致死的損傷例 (2015)
  • Author(s): 近藤稔和，岩橋優美，川口敬士，濵 瑞貴，島田栄美，山本寛記，吉良英知，川口真理子，國中由美，野坂みずほ，石田裕子，木村章彦
  • Organizer: 第22回法医病理夏期セミナー
  • Place of Presentation: 岩手大学（岩手県盛岡市）
  • Year and Date: 2015-09-04
• [Presentation] 深部静脈血栓モデルにおけるIL-6の病態生理学的役割 (2015)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，向田直史，近藤稔和
  • Organizer: 第36回日本炎症・再生医学会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2015-07-21
• [Presentation] IFN-γは１型心腎連関において保護的に機能する (2015)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，向田直史，近藤稔和
  • Organizer: 第36回日本炎症・再生医学会
  • Place of Presentation: 虎ノ門ヒルズフォーラム（東京都港区）
  • Year and Date: 2015-07-21
• [Presentation] Immunohistochemical analysis on MMP-2 and MMP-9 for wound age determination (2015)
  • Author(s): 石田裕子，國中由美，野坂みずほ，木村章彦，川口敬士，濵瑞貴，坂本翔一，篠崎浩平，Wolfgang Eisenmenger，近藤稔和
  • Organizer: 第99次日本法医学会学術全国集会
  • Place of Presentation: 高知市文化プラザ かるぽーと（高知県高知市）
  • Year and Date: 2015-06-12
• [Presentation] Lack of IFN-γ exaggerates ANG II-induced aortic dissection (2015)
  • Author(s): 木村章彦，石田裕子，野坂みずほ，川口敬士，濵瑞貴，山本寛記，近藤稔和
  • Organizer: 第99次日本法医学会学術全国集会
  • Place of Presentation: 高知市文化プラザ かるぽーと（高知県高知市）
  • Year and Date: 2015-06-12
• [Presentation] 深部静脈血栓症における骨髄由来fibrocyteの動態と法医診断学的応用に関する研究 (2015)
  • Author(s): 野坂みずほ，石田裕子，木村章彦，川口敬士，濵瑞貴，篠崎浩平，坂本翔一，國中由美，川口真理子，近藤稔和．深部静脈血栓症における骨髄由来fibrocyteの動態と法医診断学的応用に関する研究
  • Organizer: 第99次日本法医学会学術全国集会
  • Place of Presentation: 高知市文化プラザ かるぽーと（高知県高知市）
  • Year and Date: 2015-06-11
• [Presentation] フェニトロチオンを含む2種の農薬を同時に検出した3事例 (2015)
  • Author(s): 高安達典，石田裕子，野坂みずほ，川口真理子，國中由美，山本寛記，木村章彦，近藤稔和
  • Organizer: 第99次日本法医学会学術全国集会
  • Place of Presentation: 高知市文化プラザ かるぽーと（高知県高知市）
  • Year and Date: 2015-06-11
• [Presentation] 皮膚から読み取る法医学 (2015)
  • Author(s): 近藤稔和
  • Organizer: 第114回日本皮膚科学会総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2015-05-30
  • Invited
• [Presentation] 法医診断における分子病理学の応用 (2015)
  • Author(s): 近藤稔和
  • Organizer: 公開ワークショップ 法医鑑定・死因究明のための新しい概念と技術－死から命を学ぶ－
  • Place of Presentation: 大阪市
  • Year and Date: 2015-05-02