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Observation of smooth muscle cell transformation in cerebral blood vessel using differentiation marker and its application to forensic examination.

Research Project

Project/Area Number 15K08887
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionSt. Marianna University School of Medicine (2016-2017)
Tokyo Women's Medical University (2015)

Principal Investigator

Ro Ayako  聖マリアンナ医科大学, 医学部, 准教授 (50296555)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords脳血管 / クモ膜下出血 / 脳動脈瘤 / 平滑筋細胞 / 法医病理学 / 脳動脈 / 中膜平滑筋 / 血管中膜平滑筋 / 突然死 / 法医病理 / 血管リモデリング
Outline of Final Research Achievements

Histopathological features of cerebral arteries focusing on the medial smooth muscle cells for forensic diagnosis of sudden death due to cerebral arterial rupture were examined. In cases of vertebral artery dissection, segmental arterial mediolysis was observed as a causative lesion in all examined cases. The response of mesenchymal cells found at the rupture site was considered to be a useful finding for distinguishing from traumatic vertebral arterial rupture. In the cases of a saccular aneurysm, the morphology and distribution of the medial smooth muscle cells enables to evaluate growth course of the aneurysm. That is useful for forensic practice in the point of grasping the case's prenatal course.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (6 results)

  • [Journal Article] Pathomorphological Examination of Patients with the Simultaneous Rupture of Dissecting Intracranial Vertebral and Intraperitoneal Arteries: Involvement of Segmental Arterial Mediolysis in Intracranial Artery Dissection2018

    • Author(s)
      RO Ayako, KAGEYAMA Norimasa, MUKAI Toshiji.
    • Journal Title

      Journal of Neuroendovascular Therapy

      Volume: 12 Issue: 4 Pages: 161-168

    • DOI

      10.5797/jnet.oa.2017-0054

    • NAID

      130006712514

    • ISSN
      1882-4072, 2186-2494
    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳血管の免疫組織学的性状と動脈瘤との関係.2018

    • Author(s)
      呂 彩子、景山則正.
    • Organizer
      第43回日本脳卒中学会総会.福岡国際センター(福岡県福岡市)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 脳底動脈嚢状脳動脈瘤の病理形態学的特徴.2017

    • Author(s)
      呂 彩子、景山則正.
    • Organizer
      第42回日本脳卒中学会総会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] 破裂・未破裂脳動脈瘤剖検例における血管壁の免疫組織学的観察.2017

    • Author(s)
      呂 彩子、景山則正.
    • Organizer
      第33回NPO法人日本脳神経血管内治療学会学術総会.グランドプリンスホテル新高輪 (東京都港区)
    • Related Report
      2017 Annual Research Report
  • [Presentation] 椎骨動脈解離破裂によるクモ膜下出血に腹腔内動脈解離破裂が同時に認められた4剖検例:SAMとの関連について.2016

    • Author(s)
      呂 彩子,景山則正.
    • Organizer
      第32回NPO法人日本脳神経血管内治療学会学術総会
    • Place of Presentation
      神戸国際展示場(兵庫県・神戸市)
    • Year and Date
      2016-11-24
    • Related Report
      2016 Research-status Report
  • [Presentation] 髄膜炎波及による感染性動脈瘤と考えられる脳底動脈破裂によるクモ膜下出血の1剖検例2016

    • Author(s)
      呂 彩子、景山則正
    • Organizer
      第41回日本脳卒中学会総会
    • Place of Presentation
      さっぽろ芸術文化の館(北海道札幌市)
    • Year and Date
      2016-04-14
    • Related Report
      2015 Research-status Report
  • [Presentation] 病理組織からみた前大脳・前交通動脈合流部の破裂嚢状動脈瘤における母動脈と瘤の形態的特徴2015

    • Author(s)
      呂 彩子、景山則正
    • Organizer
      第31回NPO法人日本脳神経血管内治療学会学術総会
    • Place of Presentation
      岡山シティミュージアム(岡山県岡山市)
    • Year and Date
      2015-11-19
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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