| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
The ventral tegmental area-the nucleus accumbens nucleus and the nigrostriatal system dopamine (Dopamine: DA) nervous system are important neural circuits for the reinforcement effect of drugs of abuse. In chronically stimulant (Methamphetamine: MAP) treated rats, a significant difference was observed in the mRNA expression level of the dopamine transporter (Dopamine Transporter: DAT) that regulates the amount of DA in the intercellular space in brain. These results indicate that MAT-induced repeated DA overactivity was downregulated DAT function. In order to discuss the final functional expression, not only the mRNA expression rate but also the DAT protein expression rate was measured, and a decrease was observed in not only chronic administration but also single administration. This result shows that even single drug use may cause irreversible changes in the cranial nerves.
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