Involvement of inflammaging in pathophysiology and regulation of sarcopenia during aging process

• Project/Area Number: 15K08898
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: The University of Tokyo
• Principal Investigator: OGAWA SUMITO 東京大学, 医学部附属病院, 准教授 (20323579)
• Co-Investigator(Renkei-kenkyūsha): AKISHITA MASAHIRO 東京大学, 医学部附属病院, 教授 (00261975)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: サルコペニア / 老化 / 炎症老化

Outline of Final Research Achievements

In this study, involvement of inflammaging in pathophysiology and regulation of sarcopenia during aging process was studied. It was suggested that some of the Kampo medicines and its elements might possess sex hormone-like agonistic effects and effects on inflammatory regulation, further suggesting that these compounds might improve skeletal muscle property including inhibition of muscle degradation.