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Significance of foreign body reaction in the pathogenesis of aspiration pneumonia and other inflammatory respiratory diseases

Research Project

Project/Area Number 15K08899
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionThe University of Tokyo

Principal Investigator

Yamaguchi Yasuhiro  東京大学, 医学部附属病院, 講師 (60376473)

Co-Investigator(Kenkyū-buntansha) 栗原 由紀子  東京大学, 大学院医学系研究科(医学部), 講師 (80345040)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords異物反応 / 誤嚥性肺炎 / 異物
Outline of Final Research Achievements

Although pathological diagnosis of aspiration pneumonia depends on the presence of foreign body reactions to food in lungs, the pathogenic significances of these foreign body reactions have not been evaluated. We produced a novel mouse model of aspiration pneumonia by instilling intratracheally 0.1mg/g BW or 0.01mg/g BW cellulose. The bronchoalveolar lavage fluids revealed the accumulation of polymorphonuclear leukocytes in 24 hours, but its inflammation almost disappeared in 7 days. Histologically, macrophages were the dominant cell population in infiltrates around the foreign bodies in 7 days. The expressions of MIP1alpha and IL-6 increased remarkably in the acute phase of this foreign body reaction model. Staphylococcus aureus pneumonia worsened significantly by the complication with massive foreign body reactions.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (4 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Transgenic Mice Overexpressing Vitamin D Receptor (VDR) Show Anti-Inflammatory Effects in Lung Tissues.2017

    • Author(s)
      Ishii M, Yamaguchi Y, Isumi K, Ogawa S, Akishita M.
    • Journal Title

      Inflammation

      Volume: 40 Issue: 6 Pages: 2012-2019

    • DOI

      10.1007/s10753-017-0641-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In Vitro and In Vivo Anticancer Activity of Human β-Defensin-3 and Its Mouse Homolog2016

    • Author(s)
      Hanaoka Y, Yamaguchi Y*, Yamamoto H, Ishii M, Nagase T, Kurihara H, Akishita M, Ouchi Y
    • Journal Title

      Anticancer Res

      Volume: 36 Pages: 5999-6004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] The vitamin D receptors may function as anti-inflammatory effects in patients with COPD2015

    • Author(s)
      Masaki Ishii, Yasuhiro Yamaguchi, Tomomi Nakamura, Masahiro Akishita
    • Organizer
      CHEST Annual meeting
    • Place of Presentation
      Québec, Canada
    • Year and Date
      2015-10-24
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肺組織における抗炎症効果としてのビタミンD受容体機能とその発現制御因子に関する検討2015

    • Author(s)
      石井 正紀, 山口 泰弘, 中村 友美, 秋下 雅弘
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2015-04-17
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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