Development of new supportive therapy about fatigue mitigation after the cisplatin administration in cancer patients - Carnitine substitution therapy

• Project/Area Number: 15K08903
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Meijo University
• Principal Investigator: Tanabe Kouichi 名城大学, 薬学部, 准教授 (30709704)
• Co-Investigator(Kenkyū-buntansha): 菓子井 達彦 富山大学, 大学院医学薬学研究部(医学), 客員教授 (00313619) ; 梶浦 新也 富山大学, 大学院医学薬学研究部(医学), 助教 (70456383)
• Research Collaborator: IKEZAKI Tomoaki ; NITTA Atsumi ; MIWA Toshiro ; HOSOKAWA Ayumu ; YASUDA Hatsuna
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 倦怠感 / カルニチン / がん / 化学療法 / 支持療法 / 緩和医療 / シスプラチン / 緩和ケア / 尿細管障害

Outline of Final Research Achievements

In this study, we examined observation to confirm quantitatively whether blood carnitine significantly decreased by the cisplatin dosage, and what carnitine leaked through the whole urine after the cisplatin dosage. This leakage changed parallel to a rise of the β2-microglobulin which was the marker of tubular impairment, we clarified that it was the leakage due to tubular impairment.

Research Products

• [Journal Article] The relationship between carnitine pharmacokinetics and fatigue in patients treated with cisplatin-containing chemotherapy (2017)
  • Author(s): Tomoaki Ikezaki, Kensuke Suzuki, Kenta Kanbara, Minehiko Inomata, Seisuke Okazawa, Shinya Kajiura, Toshiro Miwa, Kouichi Tanabe, Tatsuhiko Kashii
  • Journal Title: Oncology Research and Treatment Volume: 40 Issue: 1-2 Pages: 42-45
  • DOI: 10.1159/000455255
  • Peer Reviewed
• [Presentation] The relationship between carnitine pharmacokinetics and fatigue in cancer patients treated with cisplatin-containing chemotherapy (2016)
  • Author(s): Kashii T, Ikezaki T, Kajiura S, Miwa T, Tanabe K
  • Organizer: 2016 American Society of Clinical Oncology Annual Meeting
  • Place of Presentation: McCormick Place, Chicago, Illinois, USA
  • Year and Date: 2016-06-03
• [Presentation] シスプラチンを含む化学療法におけるカルニチン動態と倦怠感の関連 (2015)
  • Author(s): 菓子井達彦、岡澤成祐、神原健太、猪又峰彦、鈴木健介、三輪敏郎、梶浦新也、池崎友明、田辺公一、戸邉一之
  • Organizer: 第56回日本肺癌学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-11-26
• [Presentation] シスプラチン含有化学療法におけるカルニチン動態と倦怠感の関連 (2015)
  • Author(s): 池崎友明、鈴木健介、神原健太、猪又峰彦、岡澤成佑、安田初奈、梶浦新也、三輪敏郎、田辺公一、菓子井達彦
  • Organizer: 第25回日本医療薬学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-11-21
• [Presentation] Is pharmacokinetics of carnitine a prediction factor of fatigue in cancer patients treated with cisplatin-containing chemotherapy? (2015)
  • Author(s): Kashii T, Kajiura S, Miwa T, Ikezaki T, Tanabe K
  • Organizer: European Society for Medical Oncology 2015 Congress (ESMO 2015) - European Cancer Congress 2015 (ECCO 2015) combines
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] The relationship between carnitine pharmacokinetics and fatigue in thoracic cancer patients treated with cisplatin-containing chemotherapy (2015)
  • Author(s): Kashii T, Miwa T, Suzuki K, Okazawa S, Kambara K, Inomata M, Ikezaki T, Tanabe K, Yasuda H, Kajiura S
  • Organizer: The 16th World Conference on Lung Cancer (WCLC/IASLC 2015)
  • Place of Presentation: Colorado Convention Ceter, Denver, Colorado, USA
  • Year and Date: 2015-09-06
  • Int'l Joint Research
• [Presentation] 肺がん化学療法におけるカルニチン動態と倦怠感の関連 (2015)
  • Author(s): 菓子井達彦、三輪敏郎、梶浦新也、田辺公一、岡澤成祐、神原健太、猪又峰彦、鈴木健介
  • Organizer: 第13回日本臨床腫瘍学会学術集会
  • Place of Presentation: ロイトン札幌・札幌市教育文化会館
  • Year and Date: 2015-07-16
• [Presentation] がん化学療法における血漿中および尿中カルニチン動態と倦怠感の関連 (2015)
  • Author(s): 田辺公一、菓子井達彦、三輪敏郎、梶浦新也、岡澤成祐、神原健太、猪又峰彦、鈴木健介
  • Organizer: 第20回日本緩和医療学会学術大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-06-18
• [Presentation] The relationship between carnitine pharmacokinetics and fatigue in patients treated with cisplatin-containing chemotherapy (2015)
  • Author(s): Kashii T, Tanabe K, Kajiura S, Miwa T
  • Organizer: 2015 American Society of Clinical Oncology Annual Meeting （ASCO 2015）
  • Place of Presentation: McCormick Place, Chicago, Illinois, USA
  • Year and Date: 2015-05-29
  • Int'l Joint Research