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Development of new supportive therapy about fatigue mitigation after the cisplatin administration in cancer patients - Carnitine substitution therapy

Research Project

Project/Area Number 15K08903
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionMeijo University

Principal Investigator

Tanabe Kouichi  名城大学, 薬学部, 准教授 (30709704)

Co-Investigator(Kenkyū-buntansha) 菓子井 達彦  富山大学, 大学院医学薬学研究部(医学), 客員教授 (00313619)
梶浦 新也  富山大学, 大学院医学薬学研究部(医学), 助教 (70456383)
Research Collaborator IKEZAKI Tomoaki  
NITTA Atsumi  
MIWA Toshiro  
HOSOKAWA Ayumu  
YASUDA Hatsuna  
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords倦怠感 / カルニチン / がん / 化学療法 / 支持療法 / 緩和医療 / シスプラチン / 緩和ケア / 尿細管障害
Outline of Final Research Achievements

In this study, we examined observation to confirm quantitatively whether blood carnitine significantly decreased by the cisplatin dosage, and what carnitine leaked through the whole urine after the cisplatin dosage. This leakage changed parallel to a rise of the β2-microglobulin which was the marker of tubular impairment, we clarified that it was the leakage due to tubular impairment.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (8 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] The relationship between carnitine pharmacokinetics and fatigue in patients treated with cisplatin-containing chemotherapy2017

    • Author(s)
      Tomoaki Ikezaki, Kensuke Suzuki, Kenta Kanbara, Minehiko Inomata, Seisuke Okazawa, Shinya Kajiura, Toshiro Miwa, Kouichi Tanabe, Tatsuhiko Kashii
    • Journal Title

      Oncology Research and Treatment

      Volume: 40 Issue: 1-2 Pages: 42-45

    • DOI

      10.1159/000455255

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] The relationship between carnitine pharmacokinetics and fatigue in cancer patients treated with cisplatin-containing chemotherapy2016

    • Author(s)
      Kashii T, Ikezaki T, Kajiura S, Miwa T, Tanabe K
    • Organizer
      2016 American Society of Clinical Oncology Annual Meeting
    • Place of Presentation
      McCormick Place, Chicago, Illinois, USA
    • Year and Date
      2016-06-03
    • Related Report
      2016 Research-status Report
  • [Presentation] シスプラチンを含む化学療法におけるカルニチン動態と倦怠感の関連2015

    • Author(s)
      菓子井達彦、岡澤成祐、神原健太、猪又峰彦、鈴木健介、三輪敏郎、梶浦新也、池崎友明、田辺公一、戸邉一之
    • Organizer
      第56回日本肺癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-11-26
    • Related Report
      2015 Research-status Report
  • [Presentation] シスプラチン含有化学療法におけるカルニチン動態と倦怠感の関連2015

    • Author(s)
      池崎友明、鈴木健介、神原健太、猪又峰彦、岡澤成佑、安田初奈、梶浦新也、三輪敏郎、田辺公一、菓子井達彦
    • Organizer
      第25回日本医療薬学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report
  • [Presentation] Is pharmacokinetics of carnitine a prediction factor of fatigue in cancer patients treated with cisplatin-containing chemotherapy?2015

    • Author(s)
      Kashii T, Kajiura S, Miwa T, Ikezaki T, Tanabe K
    • Organizer
      European Society for Medical Oncology 2015 Congress (ESMO 2015) - European Cancer Congress 2015 (ECCO 2015) combines
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] The relationship between carnitine pharmacokinetics and fatigue in thoracic cancer patients treated with cisplatin-containing chemotherapy2015

    • Author(s)
      Kashii T, Miwa T, Suzuki K, Okazawa S, Kambara K, Inomata M, Ikezaki T, Tanabe K, Yasuda H, Kajiura S
    • Organizer
      The 16th World Conference on Lung Cancer (WCLC/IASLC 2015)
    • Place of Presentation
      Colorado Convention Ceter, Denver, Colorado, USA
    • Year and Date
      2015-09-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肺がん化学療法におけるカルニチン動態と倦怠感の関連2015

    • Author(s)
      菓子井達彦、三輪敏郎、梶浦新也、田辺公一、岡澤成祐、神原健太、猪又峰彦、鈴木健介
    • Organizer
      第13回日本臨床腫瘍学会学術集会
    • Place of Presentation
      ロイトン札幌・札幌市教育文化会館
    • Year and Date
      2015-07-16
    • Related Report
      2015 Research-status Report
  • [Presentation] がん化学療法における血漿中および尿中カルニチン動態と倦怠感の関連2015

    • Author(s)
      田辺公一、菓子井達彦、三輪敏郎、梶浦新也、岡澤成祐、神原健太、猪又峰彦、鈴木健介
    • Organizer
      第20回日本緩和医療学会学術大会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-06-18
    • Related Report
      2015 Research-status Report
  • [Presentation] The relationship between carnitine pharmacokinetics and fatigue in patients treated with cisplatin-containing chemotherapy2015

    • Author(s)
      Kashii T, Tanabe K, Kajiura S, Miwa T
    • Organizer
      2015 American Society of Clinical Oncology Annual Meeting (ASCO 2015)
    • Place of Presentation
      McCormick Place, Chicago, Illinois, USA
    • Year and Date
      2015-05-29
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2019-03-29  

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