Investigation of the mechanism of acceleration of Alzheimer disease-related neuropathology by insulin resistance

• Project/Area Number: 15K08907
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Nagoya University
• Principal Investigator: UMEGAKI Hiroyuki 名古屋大学, 医学系研究科, 准教授 (40345898)
• Co-Investigator(Kenkyū-buntansha): 柳川 まどか 名古屋大学, 医学部附属病院, 助教 (50566982)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: インスリン抵抗性 / 認知症 / 血糖値 / グリコヘモグロビン / 認知機能 / 空腹時血糖 / アルツハイマー型認知症 / MCI / SCI / インスリン

Outline of Final Research Achievements

Past studies suggested that insulin resistance (IR) may be involved in the mechanism of cognitive impairment in the older subjects. In the current study we studied the association of IR and cognitive function in the older subjects with mild cognitive decline. The number of 40 subjects was involved in the analysis. All the subjects had the assessments of fasting serum glucose and insulin with several cognitive assessments including Mini Mental State Examination (MMSE). The subjects were divided into 2 groups according to the score of MMSE at the cut-off of 23/24. The level of serum insulin was statistically significantly higher in the lower MMSE group than the higher group, while there was no difference in glucose and HbA1c levels. The results suggested that IR is associated with cognitive dysfunction in the older subjects.

Research Products

• [Presentation] Cognitive function, physical function,and body compositions in elderly with diabetes (2017)
  • Author(s): Hiroyuki Umegaki,Taeko Makino,Kazuki Uemura,Hiroyuki Shimada,Takahiro Hayashi,Xian Wu Cheng,Masafumi Kuzuya
  • Organizer: AD/PD TM2017,the 13th International Conference on Alzheimer’s and Parkinson’s Diseases
  • Place of Presentation: Austria Center Bruno-Kreisky-Platz 1.1220 Wien, Austria
  • Year and Date: 2017-03-29
  • Int'l Joint Research
• [Presentation] 生活習慣病がアルツハイマー型認知症に与える影響の検討 (2015)
  • Author(s): 栁川まどか、梅垣宏行、牧野多恵子、中嶋宏貴、鈴木裕介、葛谷雅文
  • Organizer: 第３４回日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール（青森県青森市）
  • Year and Date: 2015-10-02
• [Presentation] 非糖尿病におけるインスリン抵抗性と認知機能低下との関連 (2015)
  • Author(s): 牧野多恵子、上村一貴、梅垣宏行、成憲武、吉田安子、島田裕之、葛谷雅文
  • Organizer: 第３４回日本認知症学会学術集会
  • Place of Presentation: リンクステーションホール（青森県青森市）
  • Year and Date: 2015-10-02