Research about optimal target blood pressure in very old population
Project/Area Number |
15K08910
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | Osaka University |
Principal Investigator |
Kamide Kei 大阪大学, 医学系研究科, 教授 (80393239)
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Co-Investigator(Kenkyū-buntansha) |
樂木 宏実 大阪大学, 医学系研究科, 教授 (20252679)
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Co-Investigator(Renkei-kenkyūsha) |
GONDO Yasuyuki 大阪大学, 大学院人間科学研究科, 准教授 (40250196)
IKEBE Kazunori 大阪大学, 大学院歯学研究科, 教授 (70273696)
ISHIZAKI Tatsuro 地方独立行政法人東京都健康長寿医療センター研究所, 部長 (30246045)
ARAI Yasumichi 慶應義塾大学, 医学部, 講師 (20255467)
Masui Yukie 地方独立行政法人東京都健康長寿医療センター研究所, 研究員 (10415507)
KABAYAMA Mai 大阪大学, 大学院医学系研究科, 助教 (50635498)
SUGIMOTO Ken 大阪大学, 大学院医学系研究科, 講師 (20437403)
YAMAMOTO Kouichi 大阪大学, 大学院医学系研究科, 講師 (00528424)
OGURO Ryousuke 大阪大学, 大学院医学系研究科, 特任助教 (70630705)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 超高齢者 / 高血圧治療 / 認知機能障害 / フレイル / 管理基準 / 高血圧 / 認知機能 / 老年医学 |
Outline of Final Research Achievements |
The purpose of this study is to investigate the association of blood pressure (BP) level with physical frailty status and cognitive function among 70, 80 and 90 years old community dwelling Japanese. Community-dwelling older people aged 70±1 (n=1000), 80±1 (n=978) and 90±1 (n=272) years participated in the invitation survey, SONIC study. BP, grip strength, 8-feet gait speed and cognitive function (MOCA-J) were examined on site. The physical frailty was assessed by the CHS criteria. Trend-analysis showed that subjects with higher SBP had lower MOCA-J score in age 70 years and subjects with lower SBP had lower MOCA-J score in age 90 years. These significant trends were seen only in the participants with antihypertensive treatment. Frailty status modified these trends. According to these results, BP target values should be set up by considering age differences. The causal relationship should be clarified whether the cognitive decline is caused by excessive reduction of BP.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] High plasma adiponectin levels are associated with frailty in a general old-old population: The SONIC study.2018
Author(s)
Nagasawa, M.,Takami, Y.,Akasaka, H.,Kabayama, M.,Maeda, S.,Yokoyama, S.,Fujimoto, T.,Nozato, Y.,Imaizumi, Y.,Takeda, M.,Itoh, N.,Takeya, Y.,Yamamoto, K.,Sugimoto, K.,Nakagawa, T.,Masui, Y.,Arai, Y.,Ishizaki, T.,Ikebe, K.,Gondo, Y.,Kamide, K.,Rakugi, H.
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Journal Title
Geriatrics Gerontology International
Volume: in press
Issue: 6
Pages: 839-846
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population: the SONIC study. Hypertens Res.2017
Author(s)
Ryuno H, Kamide K, Gondo Y, Kabayama M, Oguro R, Nakama C, Yokoyama S, Nagasawa M, Maeda-Hirao S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Nakagawa T, Yasumoto S, Ikebe K, Inagaki H, Masui Y, Takayama M, Arai Y, Ishizaki T, Takahashi R, Rakugi H.
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Journal Title
Hypertens Res
Volume: in press
Issue: 7
Pages: 665-670
DOI
Related Report
Peer Reviewed
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[Journal Article] Longitudinal Association of Hypertension and Diabetes Mellitus with Cognitive Functioning in a General 70-year-old Population: The SONIC Study.2017
Author(s)
Ryuno H, KamideK, Gondo Y, Kabayama M, Oguro R, Nakama C, Yokoyama S, Nagasawa M, Maeda-Hirao S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Nakagawa T, Yasumoto S, Ikebe K, Inagaki H, Masui Y, Takayama M, Arai Y, Ishizaki T, Takahashi R, Rakugi H.
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Journal Title
Hypertens Res.
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Longitudinal study of factors affecting taste sense decline in old-old individuals2017
Author(s)
Ogawa T, Uota M, Ikebe, K., Arai, Y., Kamide, K., Gondo Y, Masui, Y, Ishizaki T, Inomata C, Takeshita H, Mihara Y, Hatta K, Maeda Y.
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Journal Title
Journal of Oral Rehabilitation
Volume: in press
Issue: 1
Pages: 22-29
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Factors related to taste sensitivity in elderly: cross-sectional findings from SONIC study2017
Author(s)
Uota M, Ogawa T, Ikebe, K., Arai, Y., Kamide, K., Gondo Y, Masui, Y, Ishizaki T, Inomata C, Takeshita H, Mihara Y, Maeda Y
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Journal Title
Journal of Oral Rehabilitation
Volume: in press
Issue: 12
Pages: 1292-1300
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years: The SONIC study.2016
Author(s)
Ryuno H, Kamide K, Gondo Y, Nakama C, Oguro R, Kabayama M, Kawai T, Kusunoki H, Yokoyama S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Yamamoto K, Takeya Y, Sugimoto K, Nakagawa T, Ikebe K, Inagaki H, Masui Y, Ishizaki T, Takayama M, Arai Y, Takahashi R, Rakugi H.
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Journal Title
Hypertens Res
Volume: in press
Issue: 7
Pages: 557-63
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Association of Combination of Hypertension and Diabetes with Cognitive Function among The 70-years old Japanese General Population from Longitudinal Observation in The SONIC Study.2016
Author(s)
Ryuno H, Kamide K, Gondo Y, Kabayama M, Sugimoto K, Nakaga T, Ikebe K, Inagaki H, Masui Y, Arai Y, Ishizaki T, Rakuki H.
Organizer
Hypertension Seoul 2016
Place of Presentation
Seoul,Korea
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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[Presentation] The Association of The Blood Pressure with Frailty Indications among Community-Dwelling Older Man with or Without Antihypertensive Treatment.2016
Author(s)
Kabayama M, Kamide K, Gondo Y, Masui Y, Ryuno H, Nakaga T, Yamamoto K, Sugimoto K, Ikebe K, Arai Y, Ishizaki T, Rakuki H.
Organizer
Hypertension Seoul 2016
Place of Presentation
Seoul,Korea
Year and Date
2016-09-24
Related Report
Int'l Joint Research
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[Presentation] Association of Longevity Gene Polymorphism, FOXO3A SNP, with Hypertension in Japanese Older Subjects -SONIC Study-2015
Author(s)
Kamide K, Ryuno H, Oguro R, Nakama C, Yokoyama S, Kabayama M, Takeya M, Takeda M, Takami Y, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Rakugi H
Organizer
第38回日本高血圧学会総会
Place of Presentation
愛媛県県民文化会館(愛媛県・松山市)
Year and Date
2015-10-09
Related Report
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