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Research about optimal target blood pressure in very old population

Research Project

Project/Area Number 15K08910
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionOsaka University

Principal Investigator

Kamide Kei  大阪大学, 医学系研究科, 教授 (80393239)

Co-Investigator(Kenkyū-buntansha) 樂木 宏実  大阪大学, 医学系研究科, 教授 (20252679)
Co-Investigator(Renkei-kenkyūsha) GONDO Yasuyuki  大阪大学, 大学院人間科学研究科, 准教授 (40250196)
IKEBE Kazunori  大阪大学, 大学院歯学研究科, 教授 (70273696)
ISHIZAKI Tatsuro  地方独立行政法人東京都健康長寿医療センター研究所, 部長 (30246045)
ARAI Yasumichi  慶應義塾大学, 医学部, 講師 (20255467)
Masui Yukie  地方独立行政法人東京都健康長寿医療センター研究所, 研究員 (10415507)
KABAYAMA Mai  大阪大学, 大学院医学系研究科, 助教 (50635498)
SUGIMOTO Ken  大阪大学, 大学院医学系研究科, 講師 (20437403)
YAMAMOTO Kouichi  大阪大学, 大学院医学系研究科, 講師 (00528424)
OGURO Ryousuke  大阪大学, 大学院医学系研究科, 特任助教 (70630705)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords超高齢者 / 高血圧治療 / 認知機能障害 / フレイル / 管理基準 / 高血圧 / 認知機能 / 老年医学
Outline of Final Research Achievements

The purpose of this study is to investigate the association of blood pressure (BP) level with physical frailty status and cognitive function among 70, 80 and 90 years old community dwelling Japanese. Community-dwelling older people aged 70±1 (n=1000), 80±1 (n=978) and 90±1 (n=272) years participated in the invitation survey, SONIC study. BP, grip strength, 8-feet gait speed and cognitive function (MOCA-J) were examined on site. The physical frailty was assessed by the CHS criteria. Trend-analysis showed that subjects with higher SBP had lower MOCA-J score in age 70 years and subjects with lower SBP had lower MOCA-J score in age 90 years. These significant trends were seen only in the participants with antihypertensive treatment. Frailty status modified these trends. According to these results, BP target values should be set up by considering age differences. The causal relationship should be clarified whether the cognitive decline is caused by excessive reduction of BP.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (22 results)

All 2018 2017 2016 2015

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Open Access: 7 results,  Acknowledgement Compliant: 3 results) Presentation (13 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] High plasma adiponectin levels are associated with frailty in a general old-old population: The SONIC study.2018

    • Author(s)
      Nagasawa, M.,Takami, Y.,Akasaka, H.,Kabayama, M.,Maeda, S.,Yokoyama, S.,Fujimoto, T.,Nozato, Y.,Imaizumi, Y.,Takeda, M.,Itoh, N.,Takeya, Y.,Yamamoto, K.,Sugimoto, K.,Nakagawa, T.,Masui, Y.,Arai, Y.,Ishizaki, T.,Ikebe, K.,Gondo, Y.,Kamide, K.,Rakugi, H.
    • Journal Title

      Geriatrics Gerontology International

      Volume: in press Issue: 6 Pages: 839-846

    • DOI

      10.1111/ggi.13258

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longitudinal association of hypertension and diabetes mellitus with cognitive functioning in a general 70-year-old population: the SONIC study. Hypertens Res.2017

    • Author(s)
      Ryuno H, Kamide K, Gondo Y, Kabayama M, Oguro R, Nakama C, Yokoyama S, Nagasawa M, Maeda-Hirao S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Nakagawa T, Yasumoto S, Ikebe K, Inagaki H, Masui Y, Takayama M, Arai Y, Ishizaki T, Takahashi R, Rakugi H.
    • Journal Title

      Hypertens Res

      Volume: in press Issue: 7 Pages: 665-670

    • DOI

      10.1038/hr.2017.15

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Longitudinal Association of Hypertension and Diabetes Mellitus with Cognitive Functioning in a General 70-year-old Population: The SONIC Study.2017

    • Author(s)
      Ryuno H, KamideK, Gondo Y, Kabayama M, Oguro R, Nakama C, Yokoyama S, Nagasawa M, Maeda-Hirao S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Nakagawa T, Yasumoto S, Ikebe K, Inagaki H, Masui Y, Takayama M, Arai Y, Ishizaki T, Takahashi R, Rakugi H.
    • Journal Title

      Hypertens Res.

      Volume: 印刷中

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Longitudinal study of factors affecting taste sense decline in old-old individuals2017

    • Author(s)
      Ogawa T, Uota M, Ikebe, K., Arai, Y., Kamide, K., Gondo Y, Masui, Y, Ishizaki T, Inomata C, Takeshita H, Mihara Y, Hatta K, Maeda Y.
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: in press Issue: 1 Pages: 22-29

    • DOI

      10.1111/joor.12454

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Factors related to taste sensitivity in elderly: cross-sectional findings from SONIC study2017

    • Author(s)
      Uota M, Ogawa T, Ikebe, K., Arai, Y., Kamide, K., Gondo Y, Masui, Y, Ishizaki T, Inomata C, Takeshita H, Mihara Y, Maeda Y
    • Journal Title

      Journal of Oral Rehabilitation

      Volume: in press Issue: 12 Pages: 1292-1300

    • DOI

      10.1111/joor.12442

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reply to 'Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years'.2016

    • Author(s)
      Ryuno H, Kamide K, Gondo Y, Kabayama M, Sugimoto K, Ikebe K, Ishizaki T, Arai Y, Rakugi H.
    • Journal Title

      Hypertens Res.

      Volume: 40(3) Issue: 3 Pages: 302-303

    • DOI

      10.1038/hr.2016.140

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Factors associated with risk for assisted living among community-dwelling older Japanese.2016

    • Author(s)
      Kabayama M, Mikami H, Kamide K.
    • Journal Title

      Archives Gerontology and Geriatrics

      Volume: 65 Pages: 63-69

    • DOI

      10.1016/j.archger.2016.03.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Differences in the association between high blood pressure and cognitive functioning among the general Japanese population aged 70 and 80 years: The SONIC study.2016

    • Author(s)
      Ryuno H, Kamide K, Gondo Y, Nakama C, Oguro R, Kabayama M, Kawai T, Kusunoki H, Yokoyama S, Imaizumi Y, Takeya M, Yamamoto H, Takeda M, Takami Y, Itoh N, Yamamoto K, Takeya Y, Sugimoto K, Nakagawa T, Ikebe K, Inagaki H, Masui Y, Ishizaki T, Takayama M, Arai Y, Takahashi R, Rakugi H.
    • Journal Title

      Hypertens Res

      Volume: in press Issue: 7 Pages: 557-63

    • DOI

      10.1038/hr.2016.25

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The Association of Blood Pressure with Frailty among Community-Dwelling Older People.2017

    • Author(s)
      Kabayama M,Kamide K,Gondo Y,Sugimoto K,Masui Y,Ishizaki Y,Arai Y,Rakugi H
    • Organizer
      The 21ST IAGG World Congress of Gerontology & Geriatrics
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域一般住民高齢者における喫煙と認知機能―生活習慣病の関与:SONIC研究2017

    • Author(s)
      澤山泰佳,樺山 舞,権藤恭之,龍野洋慶,関口敏彰,清重映里,赤木優也,山本浩一,杉本 研,池邉一典,新井康通,増井幸恵,石崎達郎,樂木宏実,神出 計
    • Organizer
      第53回日本循環器病予防学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 生活習慣病を有する地域一般住民高齢者における喫煙が認知機能に与える影響について:SONIC研究2017

    • Author(s)
      澤山泰佳,樺山 舞,龍野洋慶,杉本 研,権藤恭之,増井幸恵,新井康通,石崎達郎,樂木宏実,神出 計
    • Organizer
      第59回日本老年医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢地域住民におけるA/G比と認知機能との関連(SONIC研究)2017

    • Author(s)
      前田聡美,竹屋 泰,赤坂 憲,山本浩一,杉本 研,権藤恭之,石崎達郎,新井康通,神出 計,樂木宏実
    • Organizer
      第59回日本老年医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢者におけるフレイルと血中アディポネクチン濃度についての検討―SONIC研究―2017

    • Author(s)
      永澤元規,鷹見洋一,竹屋 泰,杉本 研,山本浩一,樺山 舞,池邉一典,権藤恭之,神出 計,樂木宏実
    • Organizer
      第59回日本老年医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高齢者における血圧値と認知機能の年代別関連性の検討(SONIC研究)2017

    • Author(s)
      樺山 舞,神出 計,龍野洋慶,権藤恭之,山本浩一,杉本 研,増井幸恵,新井康通,石崎達郎,樂木宏実
    • Organizer
      第59回日本老年医学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 身体的フレイル指標および高次生活機能をアウトカムとした高齢者高血圧の治療における高圧下限値の検討―SONIC研究2016

    • Author(s)
      樺山 舞,神出 計,龍野洋慶,中間千香子,横山世理奈,永澤元規,平尾聡美,小黒亮輔,山本浩一,杉本 研,樂木宏実
    • Organizer
      第39回日本高血圧学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report
  • [Presentation] Association of Combination of Hypertension and Diabetes with Cognitive Function among The 70-years old Japanese General Population from Longitudinal Observation in The SONIC Study.2016

    • Author(s)
      Ryuno H, Kamide K, Gondo Y, Kabayama M, Sugimoto K, Nakaga T, Ikebe K, Inagaki H, Masui Y, Arai Y, Ishizaki T, Rakuki H.
    • Organizer
      Hypertension Seoul 2016
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] The Association of The Blood Pressure with Frailty Indications among Community-Dwelling Older Man with or Without Antihypertensive Treatment.2016

    • Author(s)
      Kabayama M, Kamide K, Gondo Y, Masui Y, Ryuno H, Nakaga T, Yamamoto K, Sugimoto K, Ikebe K, Arai Y, Ishizaki T, Rakuki H.
    • Organizer
      Hypertension Seoul 2016
    • Place of Presentation
      Seoul,Korea
    • Year and Date
      2016-09-24
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 70歳前期高齢者における高血圧と認知機能低下との関連-SONIC研究3年間の追跡調査からの知見-2015

    • Author(s)
      龍野洋慶,神出 計,権藤恭之,小黒亮輔,中間千香子,樺山 舞,池邉一典,新井康通,石崎達郎,樂木宏実
    • Organizer
      第26回日本老年医学会近畿地方会
    • Place of Presentation
      京都府立医科大学(京都府・京都市)
    • Year and Date
      2015-11-14
    • Related Report
      2015 Research-status Report
  • [Presentation] Association of Longevity Gene Polymorphism, FOXO3A SNP, with Hypertension in Japanese Older Subjects -SONIC Study-2015

    • Author(s)
      Kamide K, Ryuno H, Oguro R, Nakama C, Yokoyama S, Kabayama M, Takeya M, Takeda M, Takami Y, Itoh N, Takeya Y, Yamamoto K, Sugimoto K, Rakugi H
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛県県民文化会館(愛媛県・松山市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 高齢期における動脈硬化進展リスクの検討-SONIC研究3年間の追跡調査からの知見-2015

    • Author(s)
      龍野洋慶,神出 計,中間千香子,樺山 舞,小黒亮輔,横山世理奈,武田昌生,伊東範尚,鷹見洋一,竹屋美幸,竹屋 泰,山本浩一,杉本 研,樂木宏実
    • Organizer
      第38回日本高血圧学会総会
    • Place of Presentation
      愛媛県県民文化会館(愛媛県・松山市)
    • Year and Date
      2015-10-09
    • Related Report
      2015 Research-status Report
  • [Presentation] 高齢者における高血圧と認知機能との関連-服薬アドヒアランスの影響:SONIC研究-2015

    • Author(s)
      龍野洋慶,神出 計,権藤恭之,小黒亮輔,中間千香子,樺山 舞,池邉一典,新井康通,石崎達郎,樂木宏実
    • Organizer
      第57回日本老年医学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2015-06-12
    • Related Report
      2015 Research-status Report
  • [Book] 未来共生学 vol.42017

    • Author(s)
      神出 計(分担執筆)
    • Total Pages
      465
    • Publisher
      大阪大学未来戦略機構第5部門未来共生イノベーター博士課程プログラム
    • Related Report
      2016 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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