The development of the clinical course and the animal model of Alzheimer's disease dementia with cerebrovascular disease

Research Project

Project/Area Number	15K08911
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	General internal medicine(including psychosomatic medicine)
Research Institution	Osaka University
Principal Investigator	Takeya Yasushi 大阪大学, 医学系研究科, 助教 (70590339)
Co-Investigator(Kenkyū-buntansha)	樂木宏実大阪大学, 医学系研究科, 教授 (20252679) 杉本研大阪大学, 医学系研究科, 講師 (20437403) 里直行国立研究開発法人国立長寿医療研究センター, 分子基盤研究部, 部長 (70372612)
Research Collaborator	SATO Naoyuki 国立長寿医療研究センター, 認知症先進医療開発センター・分子基盤研究部, 部長 (70372612)
Project Period (FY)	2015-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	アルツハイマー病 / 認知症 / FAST / 脳血管障害を伴うアルツハイマー病 / サルコペニア / 動物モデル / 脳血管障害 / ADL / 血管障害モデルマウス / FAST分類 / ＡＤＬ
Outline of Final Research Achievements	For Alzheimer's disease patients including mild cognitive impairment, I investigated a cognitive usability test, the atrophy of the parahippocampal gyrus by the MRI and an evaluation of the cerebrovascular disease, the phenotype about the cognitive function and chased it every one year. There were 55 cases that were able to complete a follw-up survey after one year later. There was a drop of the ADL admitted for initial dementia of MMSE18 point - 22 points by the AD with CVD in comparison with AD, but this difference disappeared after 17 points of within medium grades symptom dementia. In addition, it was inadequate for an evaluation model of the ADL because of large variability in cognitive function and social behavior in the model with the AD with CVD model mouse.