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Development of a novel anti-sarcopenia agent using drug re-positioning method with iPS cells

Research Project

Project/Area Number 15K08912
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionOsaka University

Principal Investigator

Hagihara Keisuke  大阪大学, 医学系研究科, 特任教授(常勤) (60423183)

Co-Investigator(Kenkyū-buntansha) 岸田 友紀  大阪大学, 医学系研究科, その他 (20423163)
中西 美保  滋賀医科大学, 医学部, 助教 (40382048)
Research Collaborator NUNOMURA Kazuto  大阪大学, 薬学研究科, 特任研究員
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsiPS細胞 / ドラッグリポジショニング / サルコペニア
Outline of Final Research Achievements

Frailty, means the elders who need care in the near future, Sarcopenia has been noted in the physical aspect of frailty. We already reported the effect of Go-sha-jinki-Gan (GJG) on sarcopenia by using senescence-accelerated mice (SAMP8) via normalizing signal transduction through the IGF-1-Akt axis, mitochondrial-related transcription factors, and suppressed TNF-α. We investigated an active ingredient derived from components of GJG as a candidate of anti-sarcopenic drug. We established iPS cell lines derived from SAMP8 mice, however, the effect of GJG on C2C12 cells, a mice muscle cell line, was weak using several in vitro assays. Next, we focused on the anti-inflammatory effect of GJG. GJG showed an inhibitory effect on the production of TNF-α in SAMP 8 mouse and mouse macrophage-like cell line RAW 264.7 cells. Cinnamaldehyde derived from Cinnamon Bark and Chikusetsususaponin - V derived from Achyranthes Root could be a candidate for new anti - sarcopenia agent.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (7 results)

All 2018 2017 2015

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (3 results) (of which Invited: 3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] フレイル・サルコペニア対策における漢方補腎薬の役割について2018

    • Author(s)
      萩原圭祐
    • Journal Title

      臨床栄養

      Volume: 132 Pages: 295-302

    • Related Report
      2017 Annual Research Report
  • [Journal Article] An herbal medicine, Go-sha-jinki-gan (GJG), increases muscle weight in severe muscle dystrophy model mice2017

    • Author(s)
      Yusei Takemoto, Shoya Inaba, Lidan Zhang, Kousuke Baba, Keisuke Hagihara, So-ichiro Fukada'Correspondence information about the author So-ichiro FukadaEmail the author So-ichiro Fukada
    • Journal Title

      Clinical Nutrition Experimental

      Volume: 16 Pages: 13-23

    • DOI

      10.1016/j.yclnex.2017.08.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 腎虚と補腎剤2017

    • Author(s)
      山本亜沙子、中田英之、萩原圭祐
    • Journal Title

      アンチ・エイジング医学

      Volume: 13 Pages: 40-45

    • Related Report
      2017 Annual Research Report
  • [Presentation] フレイル・サルコペニア対策における漢方補腎薬の役割について2017

    • Author(s)
      萩原圭祐
    • Organizer
      第17回日本抗加齢医学会総会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] フレイル・サルコペニア対策での漢方医学の役割2017

    • Author(s)
      萩原圭祐
    • Organizer
      第34回和漢医薬学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 心と体のレジリエンスを高める漢方医学 漢方補腎薬の抗サルコペニア効果について2017

    • Author(s)
      萩原圭祐
    • Organizer
      第1回日本リハビリテーション医学会秋季学術集会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] 筋の老化防止用組成物2015

    • Inventor(s)
      萩原圭祐
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015
    • Acquisition Date
      2017
    • Related Report
      2017 Annual Research Report

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Published: 2015-04-16   Modified: 2019-12-27  

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