Development of a novel anti-sarcopenia agent using drug re-positioning method with iPS cells
| Project/Area Number |
15K08912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Osaka University |
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Principal Investigator |
Hagihara Keisuke 大阪大学, 医学系研究科, 特任教授(常勤) (60423183)
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| Co-Investigator(Kenkyū-buntansha) |
岸田 友紀 大阪大学, 医学系研究科, その他 (20423163)
中西 美保 滋賀医科大学, 医学部, 助教 (40382048)
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| Research Collaborator |
NUNOMURA Kazuto 大阪大学, 薬学研究科, 特任研究員
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | iPS細胞 / ドラッグリポジショニング / サルコペニア |
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| Outline of Final Research Achievements |
Frailty, means the elders who need care in the near future, Sarcopenia has been noted in the physical aspect of frailty. We already reported the effect of Go-sha-jinki-Gan (GJG) on sarcopenia by using senescence-accelerated mice (SAMP8) via normalizing signal transduction through the IGF-1-Akt axis, mitochondrial-related transcription factors, and suppressed TNF-α. We investigated an active ingredient derived from components of GJG as a candidate of anti-sarcopenic drug. We established iPS cell lines derived from SAMP8 mice, however, the effect of GJG on C2C12 cells, a mice muscle cell line, was weak using several in vitro assays. Next, we focused on the anti-inflammatory effect of GJG. GJG showed an inhibitory effect on the production of TNF-α in SAMP 8 mouse and mouse macrophage-like cell line RAW 264.7 cells. Cinnamaldehyde derived from Cinnamon Bark and Chikusetsususaponin - V derived from Achyranthes Root could be a candidate for new anti - sarcopenia agent.
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Report
(4 results)
Research Products
(7 results)
