| Project/Area Number |
15K08913
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Osaka University |
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Principal Investigator |
Takeda Masao 大阪大学, 医学系研究科, 特任助教(常勤) (80747113)
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| Co-Investigator(Kenkyū-buntansha) |
山本 浩一 大阪大学, 医学系研究科, 講師 (00528424)
樂木 宏実 大阪大学, 医学系研究科, 教授 (20252679)
神出 計 大阪大学, 医学系研究科, 教授 (80393239)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アルツハイマー病 / バイオマーカー / 軽度認知機能障害 / 血中バイオマーカー / 認知症 / miRNA |
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| Outline of Final Research Achievements |
It is clinically useful to detect Alzheimer’s diseases (AD), the most common cause of dementia at the early phase which is called mild cognitive impairment (MCI). However, it is difficult to predict a future cognitive decline in patients with MCI, as this population involves normal subjects. Plasma micro RNA (miRNA) is a potential biomarker of AD, and thus could be useful in predicting cognitive decline in patients with MCI. In this study, we explored miRNAs that can predict future cognitive decline in patients with MCI. We used the cohort study of the elderly at the same age, and found that 2 out of 19 plasma miRNAs decreased significantly in the subjects who reduced cognitive function during three years compared to those without progressive cognitive decline. Further validation study will be required to clarify the usefulness of the plasma miRNAs to predict cognitive decline in patients with MCI.
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