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Search for new biomarkers and Survey of cerebrovascular disease due to cancer-related hypercoagulability

Research Project

Project/Area Number 15K08915
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionOsaka University

Principal Investigator

Sakaguchi Manabu  大阪大学, 医学系研究科, 招へい教員 (70432474)

Project Period (FY) 2015-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsがん / 脳梗塞 / 多施設共同前向き観察研究 / 悪性腫瘍関連脳血管障害 / 悪性腫瘍関連動脈血栓症 / 悪性腫瘍合併脳梗塞 / 悪性腫瘍 / 脳卒中 / 過凝固状態 / 登録業務推進 / 研究事務局の再整備 / 関連論文の発表 / 研究プロトコール修正承認 / 全施設倫理審査承認 / 症例登録開始 / 血液検体採取 / REDcapシステム構築 / 一括検査体制 / 準備会議 / 国際学会参加
Outline of Final Research Achievements

We conducted a multicenter prospective observational study of active cancer and ischemic stroke at nine stroke centers in Japan. Eligible patients were followed up to 1 year after ischemic stroke. During the study periods, 135 patients who had active cancer and ischemic stroke were enrolled (median age, 75 years; 52 [38.5%] were female). The most common type of cancer was lung cancer, and 77 (57.0%) patients had and advanced cancer. Analyses showed that the survival probability after ischemic stroke was 54.1% at 1 year. The cumulative incidence of recurrent stroke and major bleeding were 10.3% and 9.0%, respectively.

Academic Significance and Societal Importance of the Research Achievements

本研究は、がん合併脳梗塞の実態調査を多施設共同前向き観察研究で行なった、我が国初めての研究である。がん患者が高齢化しており、がん患者の併存症管理の重要性が高まっている。その中でも、がんと脳卒中は共通のリスク因子があり、重要な疾患である。活動性がんを有するがん患者が脳梗塞を発症した場合、半数以上でステージ3以上の進行がんであること、1年後の生存率が54.1%であることは、今後のがん診療・脳卒中診療を行う上で、重要な知見となる。

Report

(8 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2022 2021 2020 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] The Effect of Chemotherapy on Stroke Risk in Cancer Patients.2020

    • Author(s)
      Kitano T, Sasaki T, Gon Y, Todo K, Okazaki S, Kitamura T, Kitamura Y, Sakaguchi M, Sobue T, Matsumura Y, Hattori S, Mochizuki H.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 120 Issue: 04 Pages: 714-723

    • DOI

      10.1055/s-0040-1708484

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cancer is an independent predictor of poor outcomes in patients following intracerebral hemorrhage.2018

    • Author(s)
      Gon Y, Todo K, Mochizuki H, Sakaguchi M.
    • Journal Title

      European Journal of Neurology

      Volume: 25 Issue: 1 Pages: 128-134

    • DOI

      10.1111/ene.13456

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recurrent Stroke Due to Metastatic Pulmonary Tumor Emboli as an Important Clinical Entity.2017

    • Author(s)
      Takasugi J, Sakaguchi M, Oyama N, Gon Y, Terasaki Y, Sasaki T, Nakahara S, Ohshima K, Hori Y, Morii E, Mochizuki H.
    • Journal Title

      Journal of Stroke and Cerebrovascular Diseases

      Volume: 26 Issue: 6 Pages: 108-110

    • DOI

      10.1016/j.jstrokecerebrovasdis.2017.03.012

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Ischemic stroke in cancer patients treated with direct oral anticoagulants for venous thromboembolism.2017

    • Author(s)
      Gon Y, Sakaguchi M, Takasugi J, Mochizuki H.
    • Journal Title

      Thrombosis Research

      Volume: 154 Pages: 16-18

    • DOI

      10.1016/j.thromres.2017.03.026

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Validation of an algorithm that determines stroke diagnostic code accuracy in a Japanese hospital-based cancer registry using electronic medical records.2017

    • Author(s)
      Gon Y, Kabata D, Yamamoto K, Shintani A, Todo K, Mochizuki H, Sakaguchi M.
    • Journal Title

      BMC Medical Informatics and Decision Making

      Volume: 17 Issue: 1 Pages: 157-164

    • DOI

      10.1186/s12911-017-0554-x

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] がん患者に潜む血栓塞栓症のリスク~脳梗塞~2017

    • Author(s)
      坂口 学
    • Journal Title

      Thrombosis Medicine

      Volume: 7-2 Pages: 92-99

    • Related Report
      2017 Research-status Report
  • [Presentation] Cryptogenic stroke と悪性腫瘍2022

    • Author(s)
      坂口 学
    • Organizer
      第25回日本栓子検出と治療学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] がんと脳卒中: がん関連血栓症による脳梗塞の診断と治療2021

    • Author(s)
      坂口 学
    • Organizer
      第53回日本動脈硬化学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] シンポジウム”担癌患者の脳卒中” がん関連血栓症2021

    • Author(s)
      坂口 学
    • Organizer
      第45回日本脳卒中学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] The Effect of Chemotherapy on Stroke Risk in Cancer Patients.2020

    • Author(s)
      Kitano T, Sasaki T, Gon Y, Todo K, Okazaki S, Kitamura T, Kitamura Y, Sakaguchi M, Sobue T, Matsumura Y, Hattori S, Mochizuki H
    • Organizer
      International Stroke Conference 2020
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肺癌切除術後に発症した虚血性脳血管障害の臨床的特徴2018

    • Author(s)
      大薗達彦、権泰史、渡辺光太郎、北野貴也、藤堂謙一、佐々木勉、坂口学、中村元、貴島晴彦、奥村明之進、望月秀樹
    • Organizer
      第43回日本脳卒中学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 悪性腫瘍関連脳卒中2017

    • Author(s)
      坂口 学
    • Organizer
      第4回日本心血管脳卒中学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] シンポジウム3:脳梗塞診断、治療のトピックス 脳梗塞における塞栓源検出-悪性腫瘍2017

    • Author(s)
      坂口 学
    • Organizer
      第20回日本栓子検出と治療学会
    • Related Report
      2017 Research-status Report
    • Invited

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Published: 2015-04-16   Modified: 2023-01-30  

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