Psychosocial stress by partner-loss enhanced pain behaviors in monogamous animal, prairie voles.
Project/Area Number |
15K08918
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | Kochi University |
Principal Investigator |
Osako Yoji 高知大学, 教育研究部医療学系基礎医学部門, 准教授 (40335922)
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Co-Investigator(Kenkyū-buntansha) |
由利 和也 高知大学, 教育研究部医療学系基礎医学部門, 教授 (10220534)
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Co-Investigator(Renkei-kenkyūsha) |
NISHIHARA Makoto 愛知医科大学, 医学部, 教授 (60380325)
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Project Period (FY) |
2015-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | Psychosocial stress / pain / 心理社会的修飾 / パートナーロス / プレーリーハタネズミ / 絆 |
Outline of Final Research Achievements |
Partner-loss prairie vole males showed increased anxiety-like behaviors in the open field test and elevated pain behaviors in formalin test as compared to paired males. Furthermore, there was a correlation between anxiety-like behaviors and pain-related behaviors. Concerning body temperature, partner loss increased body temperature just after the breaking bonds, and the increase persisted for at least 2 weeks. Elevation of body temperature during the open field and formalin test in the partner loss group was significantly less compared with paired males. In addition, partner-loss males showed increased of Fos immunoreactivity in the spinal dorsal horn and decreased in pain-related brain regions, especially in the prefrontal cortex and nucleus accumbens. Together, partner loss elicits anxiety-like behaviors, autonomic nervous system dysfunction, and alters pain behaviors. The brain dopamine system is involved in neural processes underlying the pain modulation by social bonds.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles.2016
Author(s)
1.Arai, A., Hirota, Y., Miyase, N., Miyata, S., Young, L. J., Osako, Y., Yuri, K., *Mitsui, S.
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Journal Title
Behavioural Brain Research
Volume: 315
Pages: 83-93
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Modulation of nociception by social bonds in monogamous animal, prairie voles2016
Author(s)
Yoji Osako, Reiko Nobuhara, Kenjiro Tanaka, Kou Takahashi, Larry J. Young, Takahiro Ushida, Makoto Nishihara, Kazunari Yuri
Organizer
16th Word Congress on Pain
Place of Presentation
PACIFICO YOKOHAMA (Yokohama, Kanagawa, JAPAN)
Year and Date
2016-09-26
Related Report
Int'l Joint Research
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