| Project/Area Number |
15K08918
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Kochi University |
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Principal Investigator |
Osako Yoji 高知大学, 教育研究部医療学系基礎医学部門, 准教授 (40335922)
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| Co-Investigator(Kenkyū-buntansha) |
由利 和也 高知大学, 教育研究部医療学系基礎医学部門, 教授 (10220534)
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| Co-Investigator(Renkei-kenkyūsha) |
NISHIHARA Makoto 愛知医科大学, 医学部, 教授 (60380325)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | Psychosocial stress / pain / 心理社会的修飾 / パートナーロス / プレーリーハタネズミ / 絆 |
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| Outline of Final Research Achievements |
Partner-loss prairie vole males showed increased anxiety-like behaviors in the open field test and elevated pain behaviors in formalin test as compared to paired males. Furthermore, there was a correlation between anxiety-like behaviors and pain-related behaviors. Concerning body temperature, partner loss increased body temperature just after the breaking bonds, and the increase persisted for at least 2 weeks. Elevation of body temperature during the open field and formalin test in the partner loss group was significantly less compared with paired males. In addition, partner-loss males showed increased of Fos immunoreactivity in the spinal dorsal horn and decreased in pain-related brain regions, especially in the prefrontal cortex and nucleus accumbens.
Together, partner loss elicits anxiety-like behaviors, autonomic nervous system dysfunction, and alters pain behaviors. The brain dopamine system is involved in neural processes underlying the pain modulation by social bonds.
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