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Psychosocial stress by partner-loss enhanced pain behaviors in monogamous animal, prairie voles.

Research Project

Project/Area Number 15K08918
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionKochi University

Principal Investigator

Osako Yoji  高知大学, 教育研究部医療学系基礎医学部門, 准教授 (40335922)

Co-Investigator(Kenkyū-buntansha) 由利 和也  高知大学, 教育研究部医療学系基礎医学部門, 教授 (10220534)
Co-Investigator(Renkei-kenkyūsha) NISHIHARA Makoto  愛知医科大学, 医学部, 教授 (60380325)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsPsychosocial stress / pain / 心理社会的修飾 / パートナーロス / プレーリーハタネズミ / 絆
Outline of Final Research Achievements

Partner-loss prairie vole males showed increased anxiety-like behaviors in the open field test and elevated pain behaviors in formalin test as compared to paired males. Furthermore, there was a correlation between anxiety-like behaviors and pain-related behaviors. Concerning body temperature, partner loss increased body temperature just after the breaking bonds, and the increase persisted for at least 2 weeks. Elevation of body temperature during the open field and formalin test in the partner loss group was significantly less compared with paired males. In addition, partner-loss males showed increased of Fos immunoreactivity in the spinal dorsal horn and decreased in pain-related brain regions, especially in the prefrontal cortex and nucleus accumbens.
Together, partner loss elicits anxiety-like behaviors, autonomic nervous system dysfunction, and alters pain behaviors. The brain dopamine system is involved in neural processes underlying the pain modulation by social bonds.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Partner Loss in Monogamous Rodents: Modulation of pain and emotional behavior in male prairie voles.2017

    • Author(s)
      Osako Yoji、Nobuhara Reiko、Arai Young-Chang P.、Tanaka Kenjiro、Young Larry J.、Nishihara Makoto、Mitsui Shinichi、Yuri Kazunari
    • Journal Title

      Psychosomatic Medicine

      Volume: 80 Issue: 1 Pages: 62-68

    • DOI

      10.1097/psy.0000000000000524

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A single prolonged stress paradigm produces enduring impairments in social bonding in monogamous prairie voles.2016

    • Author(s)
      1.Arai, A., Hirota, Y., Miyase, N., Miyata, S., Young, L. J., Osako, Y., Yuri, K., *Mitsui, S.
    • Journal Title

      Behavioural Brain Research

      Volume: 315 Pages: 83-93

    • DOI

      10.1016/j.bbr.2016.08.022

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Neuropathic pain impairs pair-bonding in Monogamous rodent.2017

    • Author(s)
      Yoji Osako, Reiko Nobuhara, Takahiro Okuda, Young-Chang P Arai, Takahiro Ushida, Kazunari Yuri
    • Organizer
      第39回日本疼痛学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Modulation of nociception by social bonds in monogamous rodents: c-Fos expression in the spinal cord and the brain “pain matrix” under conditions of inflammatory pain2017

    • Author(s)
      Takahiro Okuda, Yoji Osako, Kou Takahashi, Koji Takimoto1, Takao Okabe, Kenjiro Tanaka, Makoto Nishihara, Kazunari Yuri
    • Organizer
      第39回日本疼痛学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 痛みの社会的修飾メカニズムの一考 :一夫一婦制げっ歯類を用いた基礎的研究2017

    • Author(s)
      奥田 教宏、大迫 洋治、竹林 秀晃、滝本 幸治、宮本 謙三、宅間 豊、井上 佳和、宮本 祥子、岡部 孝生、由利 和也
    • Organizer
      第52回日本理学療法士学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 心理社会的要因による痛み関連脳領域 の変化:高社会性げっ歯類を用いた基礎研究2016

    • Author(s)
      奥田 教宏、大迫 洋治、竹林 秀晃、滝本 幸治、井上 佳和、岡部 孝生、宮本 祥子、宅間 豊、宮本 謙三、由利 和也
    • Organizer
      第45回四国理学療法士学会
    • Place of Presentation
      サンポートホール高松(香川県高松市)
    • Year and Date
      2016-11-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Modulation of nociception by social bonds in monogamous animal, prairie voles2016

    • Author(s)
      Yoji Osako, Reiko Nobuhara, Kenjiro Tanaka, Kou Takahashi, Larry J. Young, Takahiro Ushida, Makoto Nishihara, Kazunari Yuri
    • Organizer
      16th Word Congress on Pain
    • Place of Presentation
      PACIFICO YOKOHAMA (Yokohama, Kanagawa, JAPAN)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Modulation of nociception by social bonds in monogamous prairie voles: Fos expression in the spinal cord and the brain “pain matrix” under conditions of inflammatory pain2016

    • Author(s)
      Takahiro Okuda, Yoji Osako, Young-Chang P Arai, Shoko Miyamoto, Hideaki Takebayashi, Larry J Young,Takahiro Ushida, Kazunari Yuri
    • Organizer
      16th Word Congress on Pain
    • Place of Presentation
      PACIFICO YOKOHAMA (Yokohama, Kanagawa, JAPAN)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 一夫一婦制げっ歯類におけるパートナーロスによる痛みの修飾2015

    • Author(s)
      大迫洋治、西原真理、信原玲子、内田有希、牛田享宏、三井真一、Larry J. young、由利和也
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      兵庫県・神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] パロキセチンはSingle prolonged stressによって阻害されたプレーリーハタネズミのつがい形成を復元する2015

    • Author(s)
      新井亜紀、廣田湧、吉澤萌香、石澤美衣、佐藤葵、民部由莉、Larry J. Young、大迫洋治、由利和也、三井真一
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      兵庫県・神戸市
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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