| Project/Area Number |
15K08922
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Oita University |
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Principal Investigator |
Abe Koh 大分大学, 医学部, 准教授 (80336297)
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| Co-Investigator(Kenkyū-buntansha) |
宮崎 英士 大分大学, 医学部, 教授 (00264333)
石井 稔浩 大分大学, 医学部, 助教 (00528911)
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| Co-Investigator(Renkei-kenkyūsha) |
Ishii Toshiriho 大分大学, 医学部医学科, 助教 (00528911)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 禁煙 / 骨粗鬆症 / オステオポンチン / RANKL / TRACP-5b / レプチン |
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| Outline of Final Research Achievements |
As the baby-boomer generation comes to late elderly in 2025, the fracture due to osteoporosis is a serious problem that degrades quality of life. Smoking is one of the risk factors that increases the rate of bone fracture due to osteoporosis. In the present study, bone metabolism markers were measured and evaluated before and after smoking cessation treatment, for the effect of smoking on osteoporosis. TRACP-5b, ucOC, osteopontin, RANKL, etc. were measured as evaluation items. As a result, ucOC, TRACP-5b, osteopontin increased in early phase of smoking cessation, and RANKL turned to decrease. BAP, NTX was unchanged. It was suggested that smoking is related to the development of osteoporosis via osteogenesis / bone resorption marker.
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