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Clinical effects of catechin -treated masks on the prevention of influenza infection

Research Project

Project/Area Number 15K08924
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionUniversity of Shizuoka

Principal Investigator

YAMADA Hiroshi  静岡県立大学, 薬学部, 教授 (40265252)

Co-Investigator(Kenkyū-buntansha) 開發 邦宏  大阪大学, 産業科学研究所, 特任准教授(常勤) (70419464)
Research Collaborator FURUSHIMA Daisuke  静岡県立大学, 薬学部, 助教
IDE Kazuki  静岡県立大学, 薬学部, 客員共同研究員
TAKUMA Norikata  白十字ホーム, 医師
FUJII Sadako  白十字ホーム, 看護師
IIDA Norio  東京白十字病院, MSW
KOKURE Kenta  東京ばんなん白光園, MSW
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsカテキン / インフルエンザ / マスク / 臨床試験 / ランダム化比較試験 / カテキン マスク / 医療従事者 / 急性上気道炎
Outline of Final Research Achievements

Influenza is a severe, respiratory tracts illness, caused by influenza virus and easily spread in public, therefore prevention is very important. Basic experimental studies revealed that catechins inhibit viral adsorption against influenza virus. We also developed the catechin-derivative with higher efficacy against influenza virus. Then, we conducted randomized controlled trials to evaluate the effects of catechin-treated face masks on influenza prevention.
Health care workers were randomly allocated into the catechin- or non-treated mask groups for 60 days. In the first trial using natural tea catechin-treated masks, 234 participants were eligible for the study. Six participants were infected influenza (catechin, 3.4%; control, 1.7%). In the second trial using catechin derivative-treated masks, 238 participants were eligible for the study. Thirteen participants were infected (catechin, 5.8%; control, 5.1%). These results did not differ significantly.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (21 results)

All 2017 2016 2015

All Journal Article (11 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 5 results,  Open Access: 3 results) Presentation (9 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Effects of green tea gargling on the prevention of influenza infection: An analysis using Bayesian approaches2017

    • Author(s)
      Ide K, Kawasaki Y, Akutagawa M, Yamada H
    • Journal Title

      J Altern Complement Med

      Volume: 23 Issue: 2 Pages: 116-120

    • DOI

      10.1089/acm.2016.0094

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effect of gargling with tea and ingredients of tea on the prevention of influenza infection: a meta-analysis2016

    • Author(s)
      Ide K, Yamada H, Kawasaki Y
    • Journal Title

      BMC Public Health

      Volume: 16 Issue: 1 Pages: 396-396

    • DOI

      10.1186/s12889-016-3083-0

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of catechin-treated masks on the prevention of influenza infection: an exploratory randomized study2016

    • Author(s)
      Ide K, Yamada H, Takuma N, Kawasaki Y, Morohoshi H, Takenaka A, Kaihatsu K
    • Journal Title

      Jpn J Clin Pharmacol Ther.

      Volume: 47 Pages: 229-234

    • NAID

      130005250977

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anti-influenza virus effects of catechins: A molecular and clinical review2016

    • Author(s)
      Ide K, Kawasaki Y, Kawakami K, Yamada H
    • Journal Title

      Curr Med Chem.

      Volume: 23 Pages: 4773-4783

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of green tea consumption on cognitive dysfunction in an elderly population: A randomized placebo-controlled study2016

    • Author(s)
      Ide K, Yamada H, Takuma N, Kawasaki Y, Harada S, Nakase J, Ukawa Y, Sagesaka YM
    • Journal Title

      Nutr J.

      Volume: 15 Pages: 49-49

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 緑茶の効用:臨床におけるエビデンス2016

    • Author(s)
      井出和希、川崎洋平、山田浩
    • Journal Title

      機能性食品と薬理栄養

      Volume: 9 Pages: 366-373

    • Related Report
      2016 Research-status Report
  • [Journal Article] 緑茶の効用:臨床におけるエビデンス2016

    • Author(s)
      井出和希, 川崎洋平, 山田浩
    • Journal Title

      機能性食品と薬理栄養

      Volume: 9 Pages: 366-371

    • Related Report
      2015 Research-status Report
  • [Journal Article] Clinical benefits of green tea consumption for cognitive dysfunction2015

    • Author(s)
      Ide K, Yamada H.
    • Journal Title

      PharmaNutrition

      Volume: 3 Pages: 136-145

    • Related Report
      2015 Research-status Report
  • [Journal Article] Methods for estimating causal relationships of adverse events with dietary supplements2015

    • Author(s)
      Ide K, Yamada H, Kitagawa M, Kawasaki Y, Buno Y, Matsushita K, Kaji M, Fujimoto K, Waki M, Nakashima M, Umegaki K
    • Journal Title

      BMJ Open

      Volume: 5 Issue: 11 Pages: e009038-e009038

    • DOI

      10.1136/bmjopen-2015-009038

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lymphocyte vitamin C level as a potential biomarker for the progression of Parkinson’s disease2015

    • Author(s)
      Ide K, Yamada H, Umegaki K, Mizuno K, Kawakami N, Hagiwara Y, Matsumoto M, Yoshida H, ,Kim K, Shiosaki E, Yokochi T, Harada K
    • Journal Title

      Nutrition

      Volume: 31 Issue: 2 Pages: 406-408

    • DOI

      10.1016/j.nut.2014.08.001

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] サプリメントの現状と臨床医の役割2015

    • Author(s)
      山田浩
    • Journal Title

      Functional Food

      Volume: 9 Pages: 106-108

    • NAID

      40020794197

    • Related Report
      2015 Research-status Report
  • [Presentation] カテキン誘導体浸透マスクのインフルエンザ様疾患予防効果:ランダム化二重盲検比較対照試験2017

    • Author(s)
      冨嶋勝夢、池谷怜、西村拓馬、諸星晴香、藤井貞子、飯田規央、小暮健太、古島大資、井出和希、川﨑洋平、田熊規方、開發邦宏、山田浩
    • Organizer
      第14回日本カテキン学会年次学術大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 天然カテキン浸透マスクのインフルエンザ予防効果:ランダム化二重盲検比較対照試験2016

    • Author(s)
      諸星晴香、井出和希、藤井貞子、飯田規央、小暮健太、竹中綾、川﨑洋平、田熊規方、開發邦宏、山田浩
    • Organizer
      第13回日本カテキン学会年次学術大会
    • Place of Presentation
      静岡
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
  • [Presentation] 緑茶およびその成分によるインフルエンザ予防:臨床的エビデンスと今後の展望2016

    • Author(s)
      山田浩
    • Organizer
      第13回日本カテキン学会年次学術大会
    • Place of Presentation
      静岡
    • Year and Date
      2016-10-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 食の安全性・機能性を支える科学の最前線:機能性食品の安全性・有用性評価法2016

    • Author(s)
      山田浩
    • Organizer
      日本薬学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 緑茶の機能性食品科学:緑茶の効用-臨床研究のエビデンス-2015

    • Author(s)
      山田浩
    • Organizer
      第13回 日本機能性食品医用学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2015-12-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 医薬品と健康食品のエビデンスは同じか?―健康食品のランダム化比較試験の例2015

    • Author(s)
      山田浩
    • Organizer
      第36日本臨床薬理学会学術総会
    • Place of Presentation
      新宿
    • Year and Date
      2015-12-08
    • Related Report
      2015 Research-status Report
  • [Presentation] Anti-stress effect of low-caffeine green tea.2015

    • Author(s)
      Unno K, Yamada H, Hara A, Iguchi K, Nakamura Y:
    • Organizer
      19th International Conference of Functional Food Center
    • Place of Presentation
      Kobe
    • Year and Date
      2015-11-17
    • Related Report
      2015 Research-status Report
  • [Presentation] Clinical evidence of green tea consumption for cognitive dysfunction2015

    • Author(s)
      Ide K, Kawasaki Y, Yamada H
    • Organizer
      The 19th Shizuoka Forum on Health and Longevity
    • Place of Presentation
      Shizuoka
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 老化制御を目指した食品開発研究の現状:緑茶の高齢者における認知機能低下改善作用2015

    • Author(s)
      山田浩
    • Organizer
      第11回日本食品免疫学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-15
    • Related Report
      2015 Research-status Report
  • [Book] Scientific evidence for the health benefits of green tea2015

    • Author(s)
      Yamada H
    • Total Pages
      175
    • Publisher
      Japanese Tea Central Public Interest Incooperated Association
    • Related Report
      2015 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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