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The neural mechanism of sex hormone secretion

Research Project

Project/Area Number 15K08928
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine(including psychosomatic medicine)
Research InstitutionUniversity of Human Arts and Sciences

Principal Investigator

KAGITANI FUSAKO  人間総合科学大学, 人間科学部, 教授(移行) (50291133)

Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsストレス / 性ホルモン / 交感神経 / 統合中枢 / 副腎皮質
Outline of Final Research Achievements

We have examined the effect of sympathetic hyperactivity on sex hormone secretion in order to elucidate the neurogenic mechanism of sex hormone secretion abnormality caused by stress. The present study aimed to clarify, whether hypothalamus is essential for this physical stress-induced inhibition of ovarian estradiol secretion, by using decerebrate animals. In central nervous system-intact rats, electrical stimulation of a tibial afferent nerve at supra-maximal intensity for C-fibers increased the efferent activity of SON by 39%, and decreased the estradiol secretion rate from the ovary by 34%. These responses were observed in decerebrate rats, but were abolished in spinal rats. In conclusion, the present study demonstrated that the main integration center for decrease response of ovarian estradiol secretion due to SON activation produced by physical stress (tibial nerve stimulation) is located in the brain stem in anesthetized rats.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results) Book (1 results)

  • [Journal Article] Mechanism of physical stress-induced inhibition of ovarian estradiol secretion in anesthetized rats.2017

    • Author(s)
      Uchida, S, Kagitani, F.
    • Journal Title

      Autonomic Neuroscience, Basic and Clinical

      Volume: 206 Pages: 63-66

    • DOI

      10.1016/j.autneu.2017.05.011

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sympathetic regulation of ovarian functions under chronic estradiol treatment in rats.2016

    • Author(s)
      Uchida, S, Kagitani, F.
    • Journal Title

      Autonomic Neuroscience: Basic & Clinical

      Volume: 203 Pages: 1-8

    • DOI

      10.1016/j.autneu.2016.04.003

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Afferent fibers involved in the bradykinin-induced cardiovascular reflexes from the ovary in rats.2015

    • Author(s)
      Uchida, S., Kagitani, F., Hotta H.
    • Journal Title

      Autonomic Neuroscience, Basic and Clinical

      Volume: 193 Pages: 57-62

    • DOI

      10.1016/j.autneu.2015.07.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] 体性感覚刺激によるエストラジオール分泌低下反応の反射中枢2017

    • Author(s)
      内田さえ , 鍵谷方子
    • Organizer
      第94回日本生理学会大会
    • Place of Presentation
      浜松アクトシティコングレスセンター(静岡県・浜松市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Sympathetic regulation of ovarian functions under chronic estradiol treatment in rats2017

    • Author(s)
      Kagitani, F. Uchida S.
    • Organizer
      The 10th Congress of the International Society for Autonomic Neuroscience (ISAN), The 70th annual meeting of the Japan Society of Neurovegetative Research
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 麻酔ラットの身体的ストレスによる卵巣エストラジオール分泌低下反応のメカニズム2017

    • Author(s)
      内田さえ , 鍵谷方子
    • Organizer
      第12回環境生理学プレコングレス
    • Place of Presentation
      サーラシティ浜松(静岡県・浜松市)
    • Related Report
      2016 Research-status Report
  • [Presentation] Changes in the sympathetic regulation of ovarian estradiol secretion following long-term estradiol treatment in rats.2016

    • Author(s)
      鍵谷方子, 内田さえ
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] エストロゲン長期投与が卵巣交感神経機能に及ぼす影響.2015

    • Author(s)
      内田さえ, 鍵谷方子
    • Organizer
      第68回日本自律神経学会総会
    • Place of Presentation
      ウィンク愛知(愛知県・名古屋市)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
  • [Presentation] Sympathetic nerve to the ovary regulates ovarian testosterone secretion in female rats.2015

    • Author(s)
      Uchida, S., Kagitani, F.
    • Organizer
      International Society for Autonomic Neuroscience for 2015
    • Place of Presentation
      Stresa (Italy)
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report
  • [Book] 生理学実習NAVI 第2版2017

    • Author(s)
      大橋敦子(監修)鍵谷方子,上村英記,金澤佑治,森田恵子,二本松明,大沢秀雄,斉藤光代,下井俊典,志村まゆら,鈴木敦子,鈴木郁子,内田さえ
    • Total Pages
      81
    • Publisher
      医歯薬出版
    • Related Report
      2016 Research-status Report

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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