The neural mechanism of sex hormone secretion
| Project/Area Number |
15K08928
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | University of Human Arts and Sciences |
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Principal Investigator |
KAGITANI FUSAKO 人間総合科学大学, 人間科学部, 教授(移行) (50291133)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ストレス / 性ホルモン / 交感神経 / 統合中枢 / 副腎皮質 |
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| Outline of Final Research Achievements |
We have examined the effect of sympathetic hyperactivity on sex hormone secretion in order to elucidate the neurogenic mechanism of sex hormone secretion abnormality caused by stress. The present study aimed to clarify, whether hypothalamus is essential for this physical stress-induced inhibition of ovarian estradiol secretion, by using decerebrate animals. In central nervous system-intact rats, electrical stimulation of a tibial afferent nerve at supra-maximal intensity for C-fibers increased the efferent activity of SON by 39%, and decreased the estradiol secretion rate from the ovary by 34%. These responses were observed in decerebrate rats, but were abolished in spinal rats. In conclusion, the present study demonstrated that the main integration center for decrease response of ovarian estradiol secretion due to SON activation produced by physical stress (tibial nerve stimulation) is located in the brain stem in anesthetized rats.
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Report
(4 results)
Research Products
(10 results)
