| Project/Area Number |
15K08936
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | Tokai University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
金子 光代 東海大学, 医学部, 奨励研究員 (40738598)
安藤 潔 東海大学, 医学部, 教授 (70176014)
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| Research Collaborator |
KANEKO Mitsuyo 東海大学, 医学部, 研究補助員 (40738598)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 高濃度ビタミンC / 過剰鉄 / 鉄 / 高濃度ビタミンC（L-AA） / 体内鉄分量 / deferasirox |
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| Outline of Final Research Achievements |
Although high concentrations of vitamin C (H-VC) have recently been used worldwide as an alternative cancer therapy, the clinical effects of H-VC have been controversial. We assumed that the discrepancy between the anti-cancer effects of H-VC in vitro and those in vivo is due to the difference of extracellular iron ion densities. In this study, we found in vivo that in the presence of excess iron, the anti-leukemic effect of H-VC was completely abrogated, although H-VC enhances anti-leukemic effect. We also demonstrated that a reduction of excess iron restores and enhances the anti-leukemic effects of H-VC in vitro and in vivo. These results suggest that H-VC should be cautiously used for cancer patients having high levels of body iron stores, and that lowering body iron stores may enhance the anti-cancer effects of H-VC in the clinical settings.
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