| Project/Area Number |
15K08942
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General internal medicine(including psychosomatic medicine)
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| Research Institution | National Hospital Organization, Hizen Psychiatric Center |
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Principal Investigator |
Takashima Yuki 独立行政法人国立病院機構肥前精神医療センター(臨床研究部), 臨床研究部, 医師(主任クラス) (70576404)
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| Co-Investigator(Kenkyū-buntansha) |
八尾 博史 独立行政法人国立病院機構肥前精神医療センター(臨床研究部), 臨床研究部, 室長 (20265010)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 食塩摂取量 / 潜在性脳梗塞 / 高血圧 / 血管危険因子 / 脳小血管病 / 無症候性脳梗塞 / 家庭血圧 |
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| Outline of Final Research Achievements |
We investigated the effects of excess salt intake on silent brain infarction on MRI in a population-based cohort of 196 non-demented elderly subjects. After excluding cases with inadequate examinations, silent brain infarction was significantly associated with age and hypertension but not with salt intake (logistic regression analysis). In contrast, hypertension was associated with age, diabetes, body mass index (obesity), renal function, and particularly salt intake (OR 1.18, 95% confidence interval 1.05 – 1.32). Our findings indicate that excess salt intake may exert a detrimental effect on silent brain infarction through hypertension.
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