Genome and epigenome analysis of early esophageal cancer and the development of molecular diagnosis using endoscopic wash
| Project/Area Number |
15K08954
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
能正 勝彦 札幌医科大学, 医学部, 講師 (10597339)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食道癌 / エピゲノム / Fusobacterium / ゲノム / ESD |
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| Outline of Final Research Achievements |
In the current study, Fusobacterium species was detected in early esophageal cancer (squamous cell carcinoma) tissues. In addition, the positive group was significantly associated with lymphovascular invasion, suggesting its relation with biological malignancy. Thus, our data suggest that tumor Fusobacterium species is a promising biomarker of esophageal cancer and could open up exciting opportunities to improve our understanding of the pathogenesis of this disease. Moreover, our findings should help to elucidate the details of carcinogenesis and could lead to the development of a new diagnostic (i.e., esophageal wash) for patients with esophageal cancer.
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Report
(4 results)
Research Products
(1 results)
