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Genome and epigenome analysis of early esophageal cancer and the development of molecular diagnosis using endoscopic wash

Research Project

Project/Area Number 15K08954
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionSapporo Medical University

Principal Investigator

Shinomura Yasuhisa  札幌医科大学, その他部局等, 名誉教授 (90162619)

Co-Investigator(Kenkyū-buntansha) 能正 勝彦  札幌医科大学, 医学部, 講師 (10597339)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords食道癌 / エピゲノム / Fusobacterium / ゲノム / ESD
Outline of Final Research Achievements

In the current study, Fusobacterium species was detected in early esophageal cancer (squamous cell carcinoma) tissues. In addition, the positive group was significantly associated with lymphovascular invasion, suggesting its relation with biological malignancy. Thus, our data suggest that tumor Fusobacterium species is a promising biomarker of esophageal cancer and could open up exciting opportunities to improve our understanding of the pathogenesis of this disease. Moreover, our findings should help to elucidate the details of carcinogenesis and could lead to the development of a new diagnostic (i.e., esophageal wash) for patients with esophageal cancer.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (1 results)

All 2017

All Presentation (1 results) (of which Invited: 1 results)

  • [Presentation] 大腸腫瘍の発育進展におけるFusobacterium属の役割とマイクロサテライト不安定性との関連2017

    • Author(s)
      能正勝彦、篠村恭久
    • Organizer
      第3回Gut microbiota研究会
    • Related Report
      2017 Annual Research Report
    • Invited

URL: 

Published: 2015-04-16   Modified: 2019-03-29  

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