| Project/Area Number |
15K08957
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡邉 俊雄 大阪市立大学, 大学院医学研究科, 准教授 (50336773)
富永 和作 大阪医科大学, 医学部, 特別任命教員教授 (80336768)
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| Research Collaborator |
SAWADA Akinari 大阪市立大学, 大学院医学研究科, 後期臨床研究医
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | バレット食道癌 / マイクロバイオーム |
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| Outline of Final Research Achievements |
Chronic inflammation-associated cancer is relevant to microbiome. We investigated whether alteration of microbiome using antibiotics affects the development of esophageal adenocarcinoma in a rat model. All rats in control and antibiotics-group developed Barrett's esophagus. Incidence of esophageal adenocarcinoma was similar between both groups with a trend to reduced incidence in the antibiotics group (89 % in the control group versus 71 % in the antibiotics group, P = 0.365). T-RFLP analysis showed that esophageal microbiome was different between two groups such as the proportion of Lactobacillales was lower in the antibiotics group and Clostridium cluster XIVa and XVIII was higher in the antibiotics group. In conclusion, alteration of microbiome does not affect the incidence of esophageal adenocarcinoma. Microbiome may not
contribute to the development of esophageal adenocarcinoma.
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