Phosphodiesterase 2A mediate visceral hypersensitivity in a rodent model of functional dyspepsia

• Project/Area Number: 15K08961
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hyogo Medical University
• Principal Investigator: Takashi Kondo 兵庫医科大学, 医学部, 助教 (90594870)
• Co-Investigator(Kenkyū-buntansha): 大島 忠之 兵庫医科大学, 医学部, 准教授 (00381814) ; 三輪 洋人 兵庫医科大学, 医学部, 教授 (80190833)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 機能性消化管障害 / ホスホジエステラーゼ / 過敏性腸症候群 / 内臓知覚過敏 / 機能性ディスペプシア

Outline of Final Research Achievements

Our aim therefore was to investigate the expression of phosphodiesterase 2A (PDE2A) in primary afferent neurons in a mouse model of Irritable bowel syndrome (IBS) and examine its role in visceral hypersensitivity. PDE2A mRNA level in the dorsal root ganglion of IBS mice was significantly increased compared to control mice. Furthermore, intraperitoneal injections of the PDE2A inhibitor suppressed the response to colorectal distension in IBS mice. PDE2A in the primary sensory neuron may play an important role in chronic visceral hypersensitivity. These findings provide a new therapeutic target for the controlling chronic visceral hyperalgesia in IBS.

Research Products

• [Journal Article] The Role of Esophageal Hypersensitivity in Functional Heartburn. (2017)
  • Author(s): Hiroto Miwa, Takashi Kondo, Tadayuki Oshima
  • Journal Title: Curr Opin Gastroenterol. Volume: 51 Issue: 7 Pages: 571-578
  • DOI: 10.1097/mcg.0000000000000885
  • Peer Reviewed
• [Presentation] 過敏性腸症候群における内臓知覚過敏とホスホジエステラーゼとの関連 (2017)
  • Author(s): 近藤 隆、大島 忠之、三輪 洋人
  • Organizer: 日本潰瘍学会
• [Presentation] 過敏性腸症候群モデルマウスにおけるホスホジエステラーゼ2Aと内臓知覚過敏との関連 (2015)
  • Author(s): 近藤 隆
  • Organizer: 第23回 日本消化器病学会関連週間
  • Place of Presentation: 品川プリンスホテル（東京）
  • Year and Date: 2015-10-08