Molecular mechanisms of differentiation and metastasis of human gastrointestinal cancer stem cells
| Project/Area Number |
15K08970
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kyushu University |
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Principal Investigator |
Baba Eishi 九州大学, 医学研究院, 教授 (00315475)
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| Co-Investigator(Kenkyū-buntansha) |
有山 寛 九州大学, 大学病院, 助教 (80713437)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 大腸癌 / 胃癌 / 癌幹細胞 / 組織幹細胞 / オルガノイド / 上皮間葉転換 / 印環細胞癌 / 消化器癌 / スフェア |
|---|
| Outline of Final Research Achievements |
Freshly isolated human gastrointestinal cancer stem cells (CSCs) and normal tissue stem cells, which form organoid in our culture system, were examined by comprehensive gene expression analysis. Differentiated colorectal non-CSCs in the culture were demonstrated to retrieve the stem cell features in association with activation of TWIST1, a key molecule of epithelial-mesenchymal transition process. Normal gastric tissue stem cells-derived organoid exhibited signet-ring cell carcinoma-like morphology by inhibition of E-cadherin expression. These molecules regulating the behavior of CSCs and tissue stem cells could possibly become therapeutic targets for cancer chemotherapy.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Colorectal cancer stem cell population consist of heterogeneous cells based on E-cadherin expression with different tumorigenic potential in vivo2018
Author(s)
Tamura S, Isobe T, Ariyama H, Nakano M, Kikushige Y, Takaishi S, Kusaba H, Takenaka K, Ueki T, Nakamura M, Akashi K, Baba E
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Journal Title
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Efficacy and safety analysis of oxaliplatin-based chemotherapy for advanced gastric cancer with a prior treatment of cisplatin2017
Author(s)
Inadomi K, Kusaba H, Matsushita Y, Tanaka R, Mitsugi K, Arimizu K, Hirano G, Makiyama A, Ohmura H, Uchino K, Hanamura F, Shibata Y, Kuwayama M, Esaki T, Takayoshi K, Arita S, Ariyama H, Akashi K, Baba E
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Journal Title
Anticancer Res
Volume: 7
Pages: 2663-2671
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Irinotecan monotherapy as third-line or later treatment in advanced gastric cancer2017
Author(s)
Makiyama A, Arimizu K, Hirano G, Makiyama C, Matsushita Y, Shirakawa T, Ohmura H, Komoda M, Uchino K, Inadomi K, Arita S, Ariyama H, Kusaba H, Shinohara Y, Kuwayama M, Kajitani T, Oda H, Esaki T, Akashi K, Baba E
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Journal Title
Gastric Cancer
Volume: -
Issue: 3
Pages: 464-472
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] The risk factors for oxaliplatin-induced thrombocytopenia and neuropathy in advanced gastric cancer2017
Author(s)
Kyoko Inadomi, Hitoshi Kusaba, Akitaka Makiyama, Kenji Mitsugi, Keita Uchino, Shingo Tamura, Yoshihiro Shibata, Taito Esaki, Kenji Tsuchihashi, Shuji Arita, Hiroshi Ariyama, Eishi Baba
Organizer
第90回日本胃癌学会総会
Related Report
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