Development of therapeutic strategy for identification of new markers for ulcerative colitis associated colorectal cancers.

• Project/Area Number: 15K08974
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Keio University
• Principal Investigator: Iwao Yasushi 慶應義塾大学, 医学部(信濃町), 教授 (40168547)
• Co-Investigator(Kenkyū-buntansha): 金井 隆典 慶應義塾大学, 医学部(信濃町), 教授 (40245478) ; 佐藤 俊朗 慶應義塾大学, 医学部(信濃町), 准教授 (70365245)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 内視鏡 / 潰瘍性大腸炎 / 大腸癌 / 幹細胞

Outline of Final Research Achievements

The number of patients with ulcerative colitis-associated colon cancer (CAC) has been increasing along with aging of patients with ulcerative colitis (UC) that became common diseases in the past decades. However, due to its rarity, it has been difficult to promote the research using human clinical samples. Thus, we have developed a research platform for rare cancer from clinical samples using establishment of organoids library that can be expanded indefinitely on demand. Furthermore, integrated analysis of genetic mutation and gene expression profile using the established sporadic colon cancer organoids and CAC organoids would enable the identification of a specific biomarker for CAC. Clonally amplified organoids enabled to perform next-generation sequencing of CAC regardless of original sample size. In particular, we developed a system which can improve the diagnostic technology of CAC by applying molecular biomarkers obtained from organoids to endoscopic and pathological analyses.

Research Products

• [Journal Article] 今月の主題 非特異性多発性小腸潰瘍症/CEAS─遺伝子異常と類縁疾患 主題 非特異性多発性小腸潰瘍症/CEASの内視鏡所見 (2017)
  • Author(s): 細江直樹、緒方晴彦、宮永亮一、木村佳代子、高林馨、長沼誠、久松理一、今枝博之、岩男泰、金井隆典、松本主之
  • Journal Title: 胃と腸 Volume: 52 Issue: 11 Pages: 1423-1429
  • DOI: 10.11477/mf.1403201192
  • ISSN: 0536-2180, 1882-1219
  • Year and Date: 2017-10-25
  • Peer Reviewed / Open Access
• [Journal Article] 今月の症例 高分化管状腺癌を伴った胃型腺腫,いわゆる幽門腺腺腫の1例 (2017)
  • Author(s): 飽本哲兵、岩男泰、下田将之、吉田諭史、木口賀之、光永豊、藤本愛、落合康利、前畑忠輝、後藤修、西澤俊宏、浦岡俊夫、矢作直久
  • Journal Title: 胃と腸 Volume: 52 Issue: 9 Pages: 1121-1124
  • DOI: 10.11477/mf.1403201139
  • ISSN: 0536-2180, 1882-1219
  • Year and Date: 2017-08-25
  • Peer Reviewed / Open Access
• [Journal Article] The risk factor of clinical relapse in ulcerative colitis patients with low dose 5-aminosalicylic acid as maintenance therapy: A report from the IBD registry (2017)
  • Author(s): Tomohiro Fukuda, Makoto Naganuma, Shinya Sugimoto, Kosaku Nanki, Shinta Mizuno, Makoto Mutaguchi, Yoshihiro Nakazato, Nagamu Inoue, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai
  • Journal Title: PLoS One Volume: 12 Issue: 11 Pages: 935-47
  • DOI: 10.1371/journal.pone.0187737
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Endocytoscopy can be used to assess histological healing in ulcerative colitis patients with clinical and endoscopic remission (2017)
  • Author(s): Yoshihiro Nakazato, Makoto Naganuma, Shinya Sugimoto, Rieko Bessho, Mari Arai, Hiroki Kiyohara, Keiko Ono, Kosaku Nanki, Makoto Mutaguchi, Shinta Mizuno, Taku Kobayashi, Naoki Hosoe, Masayuki Shimoda, Takayuki Abe, Nagamu Inoue, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai
  • Journal Title: Endoscopy Volume: 49 Issue: 06 Pages: 560-563
  • DOI: 10.1055/s-0043-106556
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visualization and Targeting of LGR5+ Human Colon Cancer Stem Cells (2017)
  • Author(s): Shimokawa M, Ohta Y, Nishikori S, Matano M, Takano A, Fujii M, Date S, Sugimoto S, Kanai T, Sato T
  • Journal Title: Nature Volume: 印刷中 Issue: 7653 Pages: 13-14
  • DOI: 10.1038/nature22081
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes. (2017)
  • Author(s): Shunsuke Kon, et al.
  • Journal Title: Nature Cell Biology Volume: 印刷中 Issue: 5 Pages: 530-541
  • DOI: 10.1038/ncb3509
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] IL-22BP dictates characteristics of Peyer's patch follicle-associated epithelium for antigen uptake. (2017)
  • Author(s): Jinnohara T, Kanaya T, Hase K, Sakakibara S, Kato T, Tachibana N, Sasaki T, Hashimoto Y, Sato T, Watarai H, Kunisawa J, Shibata N, Williams I, Kiyono H, and Ohno H
  • Journal Title: J Exp Med Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Expansion of adult human pancreatic tissue yields organoids harbouring progenitor cells with endocrine differentiation potential. (2017)
  • Author(s): Loomans CJM, Giuliani NW, Balak J, Ringnalda F,van Gurp L, Huch M, Boj SF, Sato T, Kester L, de Sousa Lopes SMC, Roost MS, Bonner-Weir S, Engelse MA, Rabelink TJ, Heimberg H, Vries RGJ, van Oudenaarden A, Carlotti F, Clevers H, de Koning EJP
  • Journal Title: Science Translational Medicine Volume: 印刷中
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Single Species of Clostridium Subcluster XIVa Decreased in Ulcerative Colitis Patients (2016)
  • Author(s): Takeshita K, Mizuno S, Mikami Y, Sujino T, Saigusa K, Matsuoka K, Naganuma M, Sato T, Takada T, Tsuji H, Kushiro A, Nomoto K, Kanai T
  • Journal Title: Inflamm Bowel Diｓ Volume: 22 Issue: 12 Pages: 2802-2810
  • DOI: 10.1097/mib.0000000000000972
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Tissue-specific mutation accumulation in human adult stem cells during life (2016)
  • Author(s): Blokzijl F,de Ligt J,Jager M,Sasselli V,Roerink S,Sasaki N,Huch M,Boymans S,Kuijk E,Prins P, Nijman I,Martincorena I,Mokry M,Wiegerinck CL,Middendorp S,Sato T,Schwank G, Nieuwenhuis EES,Verstegen MMA,van der Laan LJW,de Jonge J,IJzermans JNM, Vries RG,van de Wetering M,Stratton MR,Clevers H,Cuppen E,van Boxtel R
  • Journal Title: Nature Volume: 238 Issue: 7624 Pages: 260-264
  • DOI: 10.1038/nature19768
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Zinc transporter SLC39A7/ZIP7 promotes intestinal epithelial self-renewal by resolving ER stress. (2016)
  • Author(s): Ohashi, W., Kimura, S., Iwanaga, T., Furusawa, Y., Irie, T., Izumi, H., Watanabe, T., Hijikata, A., Hara, T., Ohara, O., Koseki, H., Sato, T., Robine, S., Mori, H., Hattori, Y., Watarai, H., Mishima, K., Ohno, H., Hase, K., Fukada, T.
  • Journal Title: PLoS Genetics Volume: 12 Issue: 10 Pages: e1006349-e1006349
  • DOI: 10.1371/journal.pgen.1006349
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab. (2016)
  • Author(s): Saigusa K. Matsuoka K. Sugimoto S, Arai M, Kiyohara H, Takeshita K, Mizuno S, Mori K, Nanki K, Takeshita T, Nakazato Y, Yajima T, Naganuma M, Hisamatsu T, Ogata H, Iwao Y, Kanai T.
  • Journal Title: Digestive Endoscopy Volume: 28 Pages: 665-70
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) is useful to predict medium to long-term prognosis in ulcerative colitis patients with clinical remission. (2016)
  • Author(s): Arai M, Naganuma M, Sugimoto S, Kiyohara H, Ono K, Mori K, Saigusa K, Nanki K, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hosoe N, Matsuoka K, Inoue N, Ogata H, Iwao Y, Kanai T.
  • Journal Title: J Crohns Colitis Volume: 10(11) Issue: 11 Pages: 1303-1309
  • DOI: 10.1093/ecco-jcc/jjw104
  • Peer Reviewed
• [Journal Article] Retrospective analysis of growth speed of 54 lesions of colitis-associated colorectal neoplasia (2016)
  • Author(s): Yamasaki K, Matsui T, Hisabe T, Yano Y, Hirai F, Morokuma T, Iwao Y, Matsumoto T, Ohi H, Andoh A, Esaki M, Aoyagi K, Sugita A, Nakase H, Fujiya M, Higashi D, Futami K.
  • Journal Title: Anticancer Res Volume: 36 Pages: 3731-40
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer. (2016)
  • Author(s): Watanabe T, Ajioka Y, Mitsuyama K, et al.
  • Journal Title: Gastroenterology. Volume: 151 Issue: 6 Pages: 1122-1130
  • DOI: 10.1053/j.gastro.2016.08.002
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic morphologic features of ulcerative colitis-associated dysplasia classified according to the SCENIC consensus statement (2016)
  • Author(s): Sugimoto S, Naganuma M, Iwao Y, Matsuoka K, Shimoda M, Mikami S, Mizuno S, Nakazato Y, Nanki K, Inoue N, Ogata H, Kanai T.
  • Journal Title: Gastrointest Endosc. Volume: 85(3) Issue: 3 Pages: 639-646
  • DOI: 10.1016/j.gie.2016.11.013
  • Peer Reviewed
• [Journal Article] Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation (2016)
  • Author(s): Dominguez-Brauer C, Hao Z, Elia AJ, Fortin JM, Nechanitzky R, Brauer PM, Sheng Y, Mana MD, Chio II, Haight J, Pollett A, Cairns R, Tworzyanski L, Inoue S, Reardon C, Marques A, Silvester J, Cox MA, Wakeham A, Yilmaz OH, Sabatini DM, van Es JH, Clevers H, Sato T, Mak TW
  • Journal Title: Cell Stem Cell Volume: 19 Issue: 2 Pages: 205-216
  • DOI: 10.1016/j.stem.2016.04.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements. (2016)
  • Author(s): Fujii M, Shimokawa M, Date S, Takano A, Matano M, Ohta Y, Nanki K, Kawasaki K, Nakazato Y, Uraoka T, Watanabe T, Kanai T, Sato T.
  • Journal Title: Cell Stem Cell Volume: 18 Issue: 6 Pages: 827-838
  • DOI: 10.1016/j.stem.2016.04.003
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] SETD7 controls intestinal regeneration and tumorigenesis by regulating Wnt/beta-catenin and Hippo/YAP signaling (2016)
  • Author(s): Oudhoff MJ, Braam MJS, Freeman SA, Wong D, Rattray DG, Want J, Antignano F, Snyder K, Refaeli I, Hughes MR, McNagny KM, Gold MR, Arrowsmith CH, Sato T, Rossi FMV, Tatlock JT, Owen D, Brown PJ, Zaph C
  • Journal Title: Developmental Cell Volume: 37 Issue: 1 Pages: 47-57
  • DOI: 10.1016/j.devcel.2016.03.002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Coping strategies for possible flare-ups and their perceived effectiveness in patients with inflammatory bowel disease (2016)
  • Author(s): Tanaka M, Kawakami A, Iwao Y, Fukushima T, Yamamoto-Mitani N
  • Journal Title: Gastroenterol Nurs Volume: 39 Issue: 1 Pages: 42-7
  • DOI: 10.1097/sga.0000000000000201
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic Severity Predicts Long-Term Prognosis in Crohn's Disease Patients with Clinical Remission. (2016)
  • Author(s): Naganuma M, Hisamatsu T, Matsuoka K, Kiyohara H, Arai M, Sugimoto S, Mori K, Nanki K, Ohno K, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hosoe N, Inoue N, Iwao Y, Ogata H, Kanai T
  • Journal Title: Digestion Volume: 93 Issue: 1 Pages: 66-71
  • DOI: 10.1159/000441767
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Efficacy and Safety of Oral Qing-Dai in Patients with Ulcerative Colitis: A Single-Center Open-Label Prospective Study. (2016)
  • Author(s): Sugimoto S, Naganuma M, Kiyohara H, Arai M, Ono K, Mori K, Saigusa K, Nanki K, Takeshita K, Takeshita T, Mutaguchi M, Mizuno S, Ogata H, Iwao Y, Kanai T
  • Journal Title: Digestion Volume: 93 Issue: 3 Pages: 193-201
  • DOI: 10.1159/000444217
  • Peer Reviewed / Open Access
• [Journal Article] Evidence-based clinical practice guidelines for management of colorectal polyps (2015)
  • Author(s): Tanaka S, Saitoh Y, Matsuda T, Igarashi M, Matsumoto T, Iwao Y, Suzuki Y, Nishida H, Hiwatashi N, Saito H, Watanabe M, Sugano K, and Shimosegawa T
  • Journal Title: J Gastroenterol Volume: 50 Issue: 3 Pages: 252-60
  • DOI: 10.1007/s00535-014-1021-4
  • Peer Reviewed / Open Access
• [Journal Article] Risk factors for decreased bone mineral density in inflammatory bowel disease: A cross-sectional study. (2015)
  • Author(s): Wada Y, Hisamatsu T, Naganuma M, Matsuoka K, Okamoto S, Inoue N, Yajima T, Kouyama K, Iwao Y, Ogata H, Hibi T, Abe T, Kanai T
  • Journal Title: Clin Nutr Volume: 34 Issue: 6 Pages: 1202-9
  • DOI: 10.1016/j.clnu.2015.01.003
  • Peer Reviewed / Open Access
• [Journal Article] Combination Therapy with Infliximab and Thiopurine Compared to Infliximab Monotherapy in Maintaining Remission of Postoperative Crohn's Disease (2015)
  • Author(s): Sakuraba A, Okamoto S, Matsuoka K, Sato T, Naganuma M, Hisamatsu T, Iwao Y, Ogata H, Kanai T, Hibi T
  • Journal Title: Digestion. Volume: 91 Issue: 3 Pages: 233-8
  • DOI: 10.1159/000375302
  • Peer Reviewed / Open Access
• [Journal Article] Association of Visceral Fat Area, Smoking, and Alcohol Consumption with Reflux Esophagitis and Barrett's Esophagus in Japan. (2015)
  • Author(s): Matsuzaki J, Suzuki H, Kobayakawa M, Inadomi JM, Takayama M, Makino K, Iwao Y, Sugino Y, Kanai T
  • Journal Title: PLoS One. Volume: 10 Issue: 7 Pages: 1-15
  • DOI: 10.1371/journal.pone.0133865
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decreased Plasma Histidine Level Predicts Risk of Relapse in Patients with Ulcerative Colitis in Remission. (2015)
  • Author(s): Hisamatsu T, Ono N, Imaizumi A, Mori M, Suzuki H, Uo M, Hashimoto M, Naganuma M, Matsuoka K, Mizuno S, Kitazume MT, Yajima T, Ogata H, Iwao Y, Hibi T, Kanai T
  • Journal Title: PLoS One. Volume: 10 Issue: 10 Pages: 1-10
  • DOI: 10.1371/journal.pone.0140716
  • Peer Reviewed / Open Access
• [Presentation] 大腸腫瘍発生における加齢、メタボリック因子の関与の検討 (2017)
  • Author(s): 井上詠，吉田諭史，柏木和弘，別所理恵子，槇野香奈子，清水良子，高山美智代，広瀬寛，杉野吉則，岩男泰
  • Organizer: 日本総合健診医学会第45回大会
  • Place of Presentation: 東京ベイ舞浜ホテルクラブリゾート（千葉）
  • Year and Date: 2017-01-27
• [Presentation] 新専門医制度に向けた大腸肛門病専門医研修プログラム作成―内科系から見た現状と課題 (2016)
  • Author(s): 井上詠，岩男泰，長沼誠，緒方晴彦，金井隆典
  • Organizer: 第71回日本大腸肛門病学会学術集会
  • Place of Presentation: 三重県営サンアリーナ（三重県）
  • Year and Date: 2016-11-18
• [Presentation] 当院ドックでの18F-FDG PET/CTによる大腸advanced病変検出に関する成績と検討 (2016)
  • Author(s): 柏木和弘, 吉田論史, 高山美智代, 井上詠, 広瀬寛, 伊藤一成, 百島裕貴, 杉野吉則, 村上康二, 岩男泰
  • Organizer: 第57回日本人間ドック学会学術大会
  • Place of Presentation: まつもと市民芸術館（長野）
  • Year and Date: 2016-07-28
• [Presentation] 潰瘍性大腸炎術後吻合部の瘻孔に対しインフリキシマブが著効した1例 (2016)
  • Author(s): 大野恵子, 長沼誠, 新井万里, 清原裕貴, 杉本真也, 南木康作, 水野慎大, 牟田口真, 中里圭宏, 別所理恵子, 井上詠, 岩男泰, 緒方晴彦, 金井隆典
  • Organizer: 第102回日本消化器内視鏡学会関東支部例会
  • Place of Presentation: シェーンバッハ・サボー（東京都千代田区）
  • Year and Date: 2016-06-11
• [Presentation] 加齢・炎症ストレスの及ぼす腸管上皮幹細胞の分子遺伝学的変化．1PS18 ステムセルエイジング：老化の謎は解明できるか？ (2016)
  • Author(s): 佐藤俊朗，南木康作，下川真理子
  • Organizer: 第39回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] Visualization of Human Colon Cancer Stem Cells Using Organoid Technology (2016)
  • Author(s): Toshiro Sato
  • Organizer: Princess Takamatsu Cancer Research Fund. Current Status and Perspective of Cancer Stem Cell Research
  • Place of Presentation: Tokyo Palace Hotel
• [Presentation] Easy manipulation of the genome: CRISPR technology. Translational Basic Science Novel models for GI disease (2016)
  • Author(s): Toshiro Sato
  • Organizer: UEGW 2016
  • Place of Presentation: Vienna (Austria)
  • Int'l Joint Research
• [Presentation] Disease modeling of human colorectal cancer (2016)
  • Author(s): Toshiro Sato
  • Organizer: EMBO | EMBL Symposium
  • Place of Presentation: Heidelberg(Germany)
  • Int'l Joint Research
• [Presentation] Gut environments and human colorectal carcinogenesis (2016)
  • Author(s): Toshiro Sato, Shinya Sugimoto, Mami Matano
  • Organizer: Symposium 17. The intestinal microflora and cancer. The 75th Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
• [Presentation] ヒト大腸がん発がん・がん幹細胞のゲノム編集を用いた機能解析 (2016)
  • Author(s): 佐藤俊朗，太田悠木，股野麻未，藤井正幸，下川真理子
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
• [Presentation] Disease Modeling of Colorectal Cancer Using Orgnaoids. Concurrent IV Disease modeling II. (2016)
  • Author(s): Toshiro Sato
  • Organizer: ISSCR 2016
  • Place of Presentation: San Francisco
  • Int'l Joint Research
• [Presentation] isease modeling of colorectal cancer using organoids (2016)
  • Author(s): Toshiro Sato
  • Organizer: The 41st Naito Conference
  • Place of Presentation: シャトレーゼ ガトーキングダム サッポロ（北海道札幌市）
• [Presentation] 腸管上皮オルガノイド培養の確立とその応用．特別企画２ 日本から世界に向けて発信されたトップ研究 (2016)
  • Author(s): 佐藤俊朗
  • Organizer: 第102回日本消化器病学会大会
  • Place of Presentation: 京王プラザホテル(新宿)
• [Presentation] Intestinal Stem Cell Niche Signaling in Homeostatic and Diseased Epithelium. Session2. Gut homeostasis and IBD. (2016)
  • Author(s): Toshiro Sato
  • Organizer: The 5th International Forum of the 102nd General Meeting of the Japanese Society of Gastroenterology
  • Place of Presentation: 京王プラザホテル(新宿)
  • Int'l Joint Research
• [Presentation] 小腸pyogenic granuloma4例の臨床的検討． (2015)
  • Author(s): 宮永亮一、細江直樹、平田賢郎、中里圭宏、長沼誠、岩男泰、緒方晴彦、金井隆典
  • Organizer: 第101回日本消化器内視鏡学会関東支部例会
  • Place of Presentation: シェーンバッハ・サボー(東京都千代田区)
  • Year and Date: 2015-12-12
• [Presentation] Prokinetics, mosapride citrate, is useful adjunction in a morning-only bowel preparation using polyethylene glycol and electrolyte solution (PEG-ELS) plus ascorbic acid for screening colonoscopy (2015)
  • Author(s): Inoue N, Yoshida T, Kashiwagi K, Sugino Y, Iwao Y
  • Organizer: Asian Pacific Digestive Week
  • Place of Presentation: 台北(台湾)
  • Year and Date: 2015-12-03
  • Int'l Joint Research
• [Presentation] Aging, Smoking, Dyslipidemia, and Obesity Are Independently Associated With the Prevalence of Colorectal Neoplasia in Japan: Analyses of Comprehensive Health Checkup Data (2015)
  • Author(s): Inoue N, Takayama M, Makino K, Matsuzaki J, Shiomi E, Shimizu R, Yoshida T, Kashiwagi K, Hirose H, Momoshima S, Sugino Y, Iwao Y
  • Organizer: Annual Scientific Meeting of the American College of Gastroenterology.
  • Place of Presentation: ハワイ(アメリカ)
  • Year and Date: 2015-10-16
  • Int'l Joint Research
• [Presentation] Prokinetics, Mosapride Citrate, Is Useful Adjunction in a Morning-Only Bowel Preparation Using Polyethylene Glycol and Electrolyte Solution (PEG-ELS) Plus Ascorbic Acid for Screening Colonoscopy. (2015)
  • Author(s): Inoue N, Matsuzaki J, Yoshida T, Kashiwagi K, Sugino Y, Iwao Y
  • Organizer: Annual Scientific Meeting of the American College of Gastroenterology.
  • Place of Presentation: ハワイ(アメリカ)
  • Year and Date: 2015-10-16
  • Int'l Joint Research
• [Presentation] 潰瘍性大腸炎合併大腸癌初期病変の内視鏡像の検討 (2015)
  • Author(s): 長沼誠，岩男泰，金井隆典
  • Organizer: 第89回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-05-29
• [Presentation] モサプリドクエン酸塩を併用したアスコルビン酸加ポリエチレングリコール含有電解質溶液による大腸内視鏡前処置法の工夫 (2015)
  • Author(s): 井上詠，岩男泰，松崎潤太郎，吉田諭史，杉野吉則
  • Organizer: 第89回日本消化器内視鏡学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋)
  • Year and Date: 2015-05-29
• [Presentation] 潰瘍性大腸炎合併大腸癌・dysplasia の内視鏡的危険因子の検討 (2015)
  • Author(s): 長沼誠，松岡克善，岩男泰
  • Organizer: 第101回日本消化器病学会総会
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
  • Year and Date: 2015-04-23