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Role of galectin-3 and intestinal bacteria flora on NSAID-induced small intestinal ulcer

Research Project

Project/Area Number 15K08975
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKindai University

Principal Investigator

PARK Ah-Mee  近畿大学, 医学部, 講師 (70469245)

Co-Investigator(Kenkyū-buntansha) 萩原 智  近畿大学, 医学部, 講師 (40460852)
Research Collaborator TSUNODA Ikuo  近畿大学, 医学部, 教授
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsガレクチン-3 / 腸内フローラ / NSAIDs / 小腸潰瘍 / ガレクチン-3 / 小腸フローラ / マクロファージ / ガレクチン-3 / ケモカインレセプター9 / インドメタシン / ガレクチンー3 / 小腸 / 炎症
Outline of Final Research Achievements

The purpose of this study is to clarify the role of Galectin-3 (Gal3) on NSAIDs-induced intestinal ulcer. By using Gal3 knockout mice, we found that Gal-3 is a worsen factor of NSAIDs-induced intestinal ulcer. There are two possible mechanism for this negative effect of Gal3. The first one is a role of Gal3 as danger signal of activated macrophages. This molecule might cause sever inflammation. The another one is changes of intestinal bacterial flora with or without Gal-3. We found obvious differences of small intestinal flora population between wildtype mice and Gal3 mice. Those differences might affect to the ulceration by NSAIDs.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (13 results)

All 2018 2017 2016 2015

All Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: novel implication for vascular atrophy2018

    • Author(s)
      Kishimoto A, Kimura S, Nio-Kobayashi J, Takahashi-Iwanaga H, Park AM, Iwanaga T
    • Journal Title

      Exp Eye Res

      Volume: 未定 Pages: 1-9

    • DOI

      10.1016/j.exer.2018.03.024

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Murine γ-Herpesvirus 68 Induces Severe Lung Inflammation in IL-27-Deficient Mice with Liver Dysfunction Preventable by Oral Neomycin.2018

    • Author(s)
      Kyosuke Kanai, Ah-Mee Park, Akiko Watanabe, Tomohiro Arikawa, Teruhito Yasui, Hiroki Yoshida, Ikuo Tsunoda and Osamu Yoshie.
    • Journal Title

      J Immunol

      Volume: 200 Issue: 8 Pages: 2703-2713

    • DOI

      10.4049/jimmunol.1700412

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Helicobacter pylori and gut microbiota in multiple sclerosis versus Alzheimer's disease: 10 pitfalls of microbiome studies2017

    • Author(s)
      Park Ah-Mee、Omura Seiichi、Fujita Mitsugu、Sato Fumitaka、Tsunoda Ikuo
    • Journal Title

      Clin Exp Neuroimmunol

      Volume: 8 Issue: 3 Pages: 215-232

    • DOI

      10.1111/cen3.12401

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-35 suppresses lipopolysaccharide-induced airway eosinophilia in EBI3-deficient mice.2017

    • Author(s)
      Kanai K, Park AM, Yoshida H, Tsunoda I, Yoshie O.
    • Journal Title

      Journal of Immunology

      Volume: 198(1) Issue: 1 Pages: 119-127

    • DOI

      10.4049/jimmunol.1600506

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Galectin-3 Plays an Important Role in Innate Immunity to Gastric Infection by Helicobacter pylori.2016

    • Author(s)
      Park AM, Hagiwara S, Hsu DK, Liu FT, Yoshie O.
    • Journal Title

      Infection and Immunity

      Volume: 84(4) Issue: 4 Pages: 1184-1193

    • DOI

      10.1128/iai.01299-15

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Heat Shock Protein 27 Plays a Pivotal Role in Myofibroblast Differentiation and in the Development of Bleomycin-Induced Pulmonary Fibrosis2016

    • Author(s)
      Park AM, Kanai K, Itoh T, Sato T, Tsukui T, Inagaki Y, Selman M, Matsushima K, Yoshie O.
    • Journal Title

      Plos One

      Volume: 11 Issue: 2 Pages: e0148998-e0148998

    • DOI

      10.1371/journal.pone.0148998

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] mpaired expression of ATP-binding cassette transporter G2 and liver damage in erythropoietic protoporphyria2015

    • Author(s)
      Hagiwara S, Nishida N, Park AM, Sakurai T, Kawada A
    • Journal Title

      Hepatology

      Volume: 62 Issue: 5 Pages: 1638-1639

    • DOI

      10.1002/hep.27871

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Novel function of p130 protein in pulmonary fibrosis2017

    • Author(s)
      Ah-Mee Park, Ikuo Tsunoda
    • Organizer
      ConBio 2017
    • Related Report
      2017 Annual Research Report
  • [Presentation] HSP27ノックダウンによる線維芽細胞の細胞周期停止におけるE2F-4の役割2016

    • Author(s)
      朴雅美、角田郁夫
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Related Report
      2016 Research-status Report
  • [Presentation] ヘリコバクター・ピロリ菌感染おけるガレクチン-3の生体防御的役割2016

    • Author(s)
      朴雅美、義江修
    • Organizer
      第81回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] IL-35は気道における好酸球浸潤を抑制する2016

    • Author(s)
      金井 亨輔、朴 雅美、角田 郁生、吉田 裕樹、義江 修
    • Organizer
      第81回日本インターフェロン・サイトカイン学会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Year and Date
      2016-05-13
    • Related Report
      2016 Research-status Report
  • [Presentation] Galectin-3 plays important protective roles against H. pylori infection.2015

    • Author(s)
      朴雅美、義江修
    • Organizer
      第38回日本分子生物学会年会、第88回日本生化学会大会
    • Place of Presentation
      神戸ポートアイランド(神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Galectin-3 is involved in H. pylori killing by macrophages.2015

    • Author(s)
      朴雅美、義江修
    • Organizer
      がん免疫療法・マクロファージ国際会議2015
    • Place of Presentation
      東京大学(東京都文京区)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research

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Published: 2015-04-16   Modified: 2020-01-20  

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