Role of galectin-3 and intestinal bacteria flora on NSAID-induced small intestinal ulcer
| Project/Area Number |
15K08975
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kindai University |
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Principal Investigator |
PARK Ah-Mee 近畿大学, 医学部, 講師 (70469245)
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| Co-Investigator(Kenkyū-buntansha) |
萩原 智 近畿大学, 医学部, 講師 (40460852)
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| Research Collaborator |
TSUNODA Ikuo 近畿大学, 医学部, 教授
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ガレクチン-3 / 腸内フローラ / NSAIDs / 小腸潰瘍 / ガレクチン－３ / 小腸フローラ / マクロファージ / ガレクチン-３ / ケモカインレセプター9 / インドメタシン / ガレクチンｰ3 / 小腸 / 炎症 |
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| Outline of Final Research Achievements |
The purpose of this study is to clarify the role of Galectin-3 (Gal3) on NSAIDs-induced intestinal ulcer. By using Gal3 knockout mice, we found that Gal-3 is a worsen factor of NSAIDs-induced intestinal ulcer. There are two possible mechanism for this negative effect of Gal3. The first one is a role of Gal3 as danger signal of activated macrophages. This molecule might cause sever inflammation. The another one is changes of intestinal bacterial flora with or without Gal-3. We found obvious differences of small intestinal flora population between wildtype mice and Gal3 mice. Those differences might affect to the ulceration by NSAIDs.
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Report
(4 results)
Research Products
(13 results)
