The clinical application of TRP receptor as a surrogate marker and/or therapeutic target for inflammatory bowel disease
| Project/Area Number |
15K08977
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 神経ペプチド / TRPチャネル / 炎症性腸疾患 / TRPチャネルファミリー / TRPレセプター / 局所投与 |
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| Outline of Final Research Achievements |
First, In animal study, Topical TNBS colitis model rats were prepared and their effects on the treatment of self-assembled peptide topically were examined. Ulcer area and intestinal weight decreased after seven days decreased significantly. Second, in the human study, the expression of the TRP channel family in healthy volunteers and IBD patients was examined. In peripheral blood mononuclear cells, TRPV2 was lower in UC and higher in TRPM2 than in healthy volunteers. And there was a significant correlation between disease activity and ADM, IL-1 β, TRPV 2, ALB. Regarding biochemical examination of blood, there was a significant correlation between TRPV 2 and white blood cell count in UC. In the Leukocytapheresis therapy, TRPV 2 showed a tendency to increase in the improvement group although there was no significant difference.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Increased circulating levels of adrenomedullin following treatment with Daikenchuto (TU-100) in Crohn’s disease2016
Author(s)
Ken Kominato, Hiroshi Yamasaki, Keiichi Mitsuyama, Hidetoshi Takedatsu, Shinichiro Yoshioka, Kotaro Kuwaki, Teppei Kobayashi, Ryosuke Yamauchi, Shuhei Fukunaga, Osamu tsuruta, Takuji Torimura
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Journal Title
Molecular Medicine Reports
Volume: in press
Related Report
Peer Reviewed
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