Analysis of vesicle trafficking pathways utilized for the life cycle of hepatitis B virus and its application for therapies
| Project/Area Number |
15K08981
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
INOUE Jun 東北大学, 大学病院, 助教 (60455821)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | HBV / Rab5B / 生活環 / Rabタンパク質 |
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| Outline of Final Research Achievements |
To elucidate the mechanisms of hepatitis B virus (HBV) replication in hepatocytes, we analyzed the involvements of Rab protein family that works as molecular switches in the vesicle trafficking. As a result of screening, it was revealed that Rab5B regulates the release of HBV significantly. Rab5B enhances the transport of LHBs, which is required for the formation of infectious envelope, from ER to multivesicular body (MVB). Also, Rab5B regulates the transcription of 2.4/2.1 kb mRNA of HBV via hepatocyte nuclear factor 4a. It is considered that the results of this study could lead to the elucidation of hepatitis B mechanisms and the possible application for the novel antiviral treatments.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Shifting hepatitis B virus genotypes of acute hepatitis B patients in northeast Japan2016
Author(s)
Inoue J, Kondo Y, Umetsu T, Yamamoto T, Miura M, Mano Y, Kobayashi T, Obara N, Niitsuma H, Kogure T, Nakagome Y, Kimura O, Iwata T, Morosawa T, Fujisaka Y, Shimosegawa T
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Journal Title
J Med Virol
Volume: 88
Issue: 1
Pages: 69-78
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Rab5B determines HBV release pathways by promoting transport of LHBs from ER to MVB2017
Author(s)
Jun Inoue, Teruyuki Umetsu, Takuya Nakamura, Masashi Ninomiya, Takayuki Kogure, Eiji Kakazu, Tomoaki Iwata, Tatsuki Morosawa, Satoshi Takai, Akitoshi Sano, Yasuhito Tanaka, Tooru Shimosegawa
Organizer
The 68th Annual Meeting of the American Association for the Study of Liver Disease (AASLD)
Related Report
Int'l Joint Research
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[Presentation] Comprehensive analysis of the Rab family to screen membrane traffic pathways utilized by hepatitis B virus2015
Author(s)
Jun Inoue, Yasuteru Kondo, Teruyuki Umetsu, Takuya Nakamura, Takayuki Kogure, Yu Nakagome, Yuta Wakui, Tatsuki Morosawa, Yasuyuki Fujisaka, Satoshi Takai, Tooru Shimosegawa
Organizer
The 66th Annual Meeting of the American Association for the Study of Liver Disease (AASLD)
Place of Presentation
サンフランシスコ、アメリカ
Year and Date
2015-11-16
Related Report
Int'l Joint Research
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