Basic study of liver regenerative therapy by autologous bone marrow cells and growth factors of hepatic stem cells
Project/Area Number |
15K08983
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Yamagata University |
Principal Investigator |
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Project Period (FY) |
2015-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 肝再生 / 骨髄細胞 / 増殖因子 / 幹細胞 |
Outline of Final Research Achievements |
It has been shown that fibroblast growth factor 2(FGF2)and epiregulin are important as the hepatic stem-cell growth factors produced in rat bone marrow cells. This study showed that epiregulin is detected in the stem-cell niche which includes liver progenitor cells around pseudo-bile ducts, and that it helps both differentiation and proliferation of liver progenitor cells into liver cells in the mouse liver injury model. The serum epiregulin level measured by enzyme-linked immunosorbent assay in patients with various liver diseases showed a high level in cases of acute liver failure including fulminant hepatitis, which suggests that it helps liver regeneration associated with liver progenitor cells. These results suggest that bone marrow cells play a role in part in liver regeneration in severe liver injury through epiregulin.
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Academic Significance and Societal Importance of the Research Achievements |
肝臓の再生治療法として、肝臓移植の他に自己骨髄細胞を用いた細胞療法の有効性が示されている。骨髄細胞からは肝臓組織内で肝幹細胞を肝細胞へと分化・増殖させる因子が産生されており、これらの詳細を明らかにすることで、骨髄細胞を用いた肝臓再生療法の発展に寄与することできる。骨髄細胞による障害肝の再生機序の一端として、骨髄細胞が産生する液性因子のepiregulinが肝前駆細胞の分化や増殖を促している可能性が示唆された。今後の肝再生治療の発展に益する知見である。
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Report
(5 results)
Research Products
(21 results)
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[Journal Article] Serum metabolome profiles characterized by patients with hepatocellular carcinoma associated with hepatitis B and C2016
Author(s)
Saito T, Sugimoto M, Okumoto K, Haga H, Katsumi T, Mizuno K, Nishina T, Sato S, Igarashi K, Maki H, Tomita M, Ueno Y, Soga T
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Journal Title
World J Gastroenterol
Volume: 22
Issue: 27
Pages: 6224-6234
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] MiR-139-5p is associated with inflammatory regulation through c-FOS suppression, and contributes to the progression of primary biliary cirrhosis2016
Author(s)
Katsumi T, Ninomiya M, Nishina T, Mizuno K, Tomita K, Haga H, Okumoto K, Saito T, Shimosegawa T, Ueno Y
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Journal Title
Lab Invest
Volume: 96
Issue: 11
Pages: 1165-1177
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pancreatic hyperechogenicity associated with hypoadiponectinemia and insulin resistance: A Japanese population study2016
Author(s)
Makino N, Shirahata N, Honda T, Ando Y, Matsuda A, Ikeda Y, Ito M, Nishise Y, Saito T, Ueno Y, Kawata S
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Journal Title
World J Hepatol
Volume: 8
Issue: 33
Pages: 1452-1458
DOI
Related Report
Peer Reviewed / Open Access
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