| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
It has been shown that fibroblast growth factor 2（FGF2）and epiregulin are important as the hepatic stem-cell growth factors produced in rat bone marrow cells. This study showed that epiregulin is detected in the stem-cell niche which includes liver progenitor cells around pseudo-bile ducts, and that it helps both differentiation and proliferation of liver progenitor cells into liver cells in the mouse liver injury model. The serum epiregulin level measured by enzyme-linked immunosorbent assay in patients with various liver diseases showed a high level in cases of acute liver failure including fulminant hepatitis, which suggests that it helps liver regeneration associated with liver progenitor cells. These results suggest that bone marrow cells play a role in part in liver regeneration in severe liver injury through epiregulin.
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