Analysis of the factors of malignant behavior in hepatic progenitor cell marker expressing hepatocellular carcinoma
| Project/Area Number |
15K08990
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TERAI Shuji 新潟大学, 大学院医歯学総合研究科・消化器内科, 教授 (00332809)
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| Research Collaborator |
KOJIMA Yuichi
SEINO Satoshi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肝細胞癌 / 肝前駆細胞 / EpCAM / NCAM / CK19 / DLK1 / 肝前駆細胞マーカー / 腫瘍マーカー / 幹前駆細胞 |
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| Outline of Final Research Achievements |
In this study we analyzed the expression of four hepatic progenitor cell markers in 251 hepatocellular carcinomas (HCCs) with their clinical data and tumor markers, and significance of the hepatic progenitor markers in HCC for prognosis. We elucidated that EpCAM expression, DCP>300 mAU/ml, age > 60, Child-Pugh sore grade B or C were independent prognostic factors of poor outcome and were used in a new scoring system for HCC prognosis after operation. Expression of two or more HPC markers was a significant predictor of poor HCC outcome and co-related with AFP and AFP-L3 levels, blood vessel invasion and differentiation of the tumor.
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Report
(4 results)
Research Products
(18 results)
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[Journal Article] Hepatic progenitor cells of biliary origin with liver repopulation capacity2015
Author(s)
Lu WY, Bird T, Boulter L, Tsuchiya A, Cole A, Hay T, Guest R, Wojtacha D, Man TY, Mackinnon A, Ridgway R, Kendall T, Williams, Jamieson T, Raven A, Hay D, Iredale J, Clarke A, Sansom O, Forbes SJ
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Journal Title
Nature Cell Biology
Volume: 17(8)
Issue: 8
Pages: 971-983
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Factors predicting aggressiveness of non-hypervascular hepatic nodules detected on hepatobiliary phase of gadolinium ethoxybenzyl diethylene-triamine-pentaacetic-acid magnetic resonance imaging2015
Author(s)
Kanefuji T, Takano T, Suda T, Akazawa K, Yokoo T, Kamimura H, Kamimura K, Tsuchiya A, Takamura M, Kawai H, Yamagiwa S, Aoyama H, Nomoto M, Terai S
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Journal Title
World J Gastroenterol
Volume: 21(15)
Issue: 15
Pages: 4583-4591
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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