|Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|Outline of Final Research Achievements
We performed the comprehensive analysis to elucidate the clinical difference between clinically divergent identical twins with abnormality of copper metabolism. We detected the mutations in ATP7B gene which is the causative gene of Wilson’s disease. We generated induced pluripotent stem cells (iPS cells) from peripheral blood cells of each identical twin. In vitro, although we confirmed the abnormality which is the phenotype of Wilson’s disease, we could not confirm the difference in the phenotype between identical twins.