| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
The quasispecies state of HBV, HCV genome was analyzed by new sequencing technology.
In HCV, the drug resistance mutation against DAA is minor clone so called drug resistant associated variants: RAV becomes dominant after treatment. In HBV, quasispecies state in which deletion mutant of HBV-PreS2 region and Pre S1 / S2 initiation codon mutation are existed. It is formed by persistent infection with or without antiviral treatment and existent ratio 1% or more is associated with the disease state. Further In HCC cases, an increase in the existent ratio of mutated clone in PreS2 region is closely related to liver carcinogenesis.
|
