| Project/Area Number |
15K08999
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
桑木 健志 岡山大学, 大学病院, 助教 (80643387)
大西 秀樹 岡山大学, 大学病院, 助教 (30595468)
中村 進一郎 岡山大学, 大学病院, 講師 (70514230)
能祖 一裕 岡山大学, 医学部, 客員研究員 (10314668)
岩室 雅也 岡山大学, 大学病院, 助教 (30645403)
堀口 繁 岡山大学, 大学病院, 助教 (70761104)
竹内 康人 岡山大学, 大学病院, 助教 (70814200)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝細胞癌 / Notch シグナル / 上皮間葉転換 / Notchシグナル |
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| Outline of Final Research Achievements |
Cytotoxic agents have been developed to treat advanced hepatocellular carcinoma (HCC). Notch signaling is associated with carcinogenesis, epithelial-mesenchymal-transition (EMT), cancer stem cells (CSC). We investigated the effect of gamma-secretase inhibitor (GSI), a Notch inhibitor, in combination with cytotoxic agents in HCC cell lines. GSI exerts an anti-tumor effect via inhibition of EMT and CSC, consequently enhancing cell sensitivity to cytotoxic agents.
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