The analysis of the function and the clinical application of REIC/ Dkk-3 gene in digestive organ cancer
| Project/Area Number |
15K09001
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
内田 大輔 岡山大学, 大学病院, 医員 (50749215)
白羽 英則 岡山大学, 大学病院, 講師 (40379748)
那須 保友 岡山大学, 医歯薬学総合研究科, 教授 (20237572)
堤 康一郎 岡山大学, 大学病院, 助教 (40610910)
松下 浩志 岡山大学, 医学部, 客員研究員 (20786107)
岩室 雅也 岡山大学, 大学病院, 助教 (30645403)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 遺伝子治療 / REIC / DKK3 / REIC遺伝子 / 腫瘍免疫 / 膵癌 / 肝臓癌 |
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| Outline of Final Research Achievements |
The reduced expression in immortalized cells REIC/the dickkopf 3 (Dkk-3) gene induced cancer selective apotosis in cell lines of hepatocellular carcinoma and cholangio cell carcinoma. REIC/Dkk‐3 expression was decreased in resected HCC tissues by immunohistochemical staining.
The REIC/DKK3 protein and peipheral blood mononuclear cells synergistically enhanced anticancer immunological effects against pancreatic cancer cells.
The clinical trial of REIC/DKK3 gene therapy for the patients with hepatocellular carcinoma started.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Promising therapeutic efficacy of a novel REIC/Dkk-3 expressing adenoviral vector for hepatocellular carcinoma.2017
Author(s)
Sawahara H, Shiraha H, Uchida D, Kato H, Kato R, Oyama A, Nagahara T, Iwamuro M, Horiguchi S, Tsutsumi K, Mandai M, Mimura T, Wada N, Takeuchi Y, Kuwaki K, Onishi H, Nakamura S, Watanabe M, Sakaguchi M, et al.
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Journal Title
J Gastroenterol Hepatol.
Volume: -
Issue: 10
Pages: 1769-1777
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Novel REIC/Dkk-3-encoding adenoviral vector as a promising therapeutic agent for pancreatic cancer.2016
Author(s)
Sawahara H, Shiraha H, Uchida D, Kato H, Nagahara T, Iwamuro M, Kataoka J, Horiguchi S, Watanabe M, Sakaguchi M, Takaki A, Nouso K, Nasu Y, Kumon H, Okada H
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Journal Title
Cancer Gene Ther
Volume: 23
Issue: 8
Pages: 278-283
DOI
Related Report
Peer Reviewed
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