| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Outline of Final Research Achievements |
In this study, we analyzed the role of B cell activating factor (BAFF), which is one of adipokines, in the progression of fatty liver disease, using BAFF- and BAFF-receptor (BAFF-R) knockout (KO) mice. In a high fat diet (HFD) model, insulin resistance and adipose tissue inflammation were attenuated in both BAFF- and BAFF-R KO mice. Although hepatic steatosis and hepatocarginogenesis were improved in HFD-fed BAFF-KO mice, they were enhanced in HFD-fed BAFF-R KO mice. These findings suggest that BAFF would be a key molecule of progression, including hepatocarcinogenesis, of fatty liver disease.
|
