Elucidation of the protection of BCAA( branched-chain amino acid) for lipid intestinal absorption disorder in patients with liver cirrhosis.
| Project/Area Number |
15K09008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Ehime University |
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Principal Investigator |
Takeshita Eiji 愛媛大学, 医学系研究科, 寄附講座准教授 (40750542)
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| Co-Investigator(Kenkyū-buntansha) |
山本 安則 公益財団法人がん研究会, 有明病院 消化器内科, 医員 (20649066)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 肝硬変 / 小腸 / 門脈圧亢進症 / 脂質吸収 / 小腸粘膜 / 消化吸収機構 |
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| Outline of Final Research Achievements |
Fat lipid, especially dietary long-chain fatty acids (LCFAs) intestinal absorption, and branched-chain amino acid (BCAA) play very important role in patients with liver cirrhosis. In this study, we evaluate an influence of BCAA on LCFAs intestinal absorption. We investigate the distinction between healthy controls and liver cirrhosis with or without portal hypertension in LCFAs intestinal absorption. LCFAs intestinal absorption in patients with liver cirrhosis, especially these with portal hypertension, were significantly lower than in healthy control (p< 0.01). Molecular biological examination by small intestine biopsy specimens showed that the expression of FATP4 and I-FABP of liver cirrhosis with portal hypertension were significantly lower than those of healthy control respectively. BCAA improved LCFA absorption which were decreased due to liver cirrhosis. The possibility that BCAA improve LCFA small intestinal absorption in patients with liver cirrhosis was suggested.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Upregulated absorption of dietary palmitic acids with changes in intestinal transporters in non-alcoholic steatohepatitis (NASH)2017
Author(s)
Utsunomiya H, Yamamoto Y, Takeshita E, Tokumoto Y, Tada F, Miyake T, Hirooka M, Abe M, Kumagi T, Matsuura B, Ikeda Y, Hiasa Y
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Journal Title
J Gastroenterol
Volume: 印刷中
Issue: 8
Pages: 940-954
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] NASHにおける小腸粘膜からの食事由来パルミチン酸の吸収動態変化と病態への影響2017
Author(s)
宇都宮 大貴, 山本 安則, 竹下 英次, 徳本 良雄, 多田 藤政, 三宅 映己, 廣岡 昌史, 阿部 雅則, 熊木 天児, 松浦 文三, 池田 宜央, 日浅 陽一
Organizer
第60回日本糖尿病学会年次学術講演会
Related Report
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