| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Fat lipid, especially dietary long-chain fatty acids (LCFAs) intestinal absorption, and branched-chain amino acid (BCAA) play very important role in patients with liver cirrhosis. In this study, we evaluate an influence of BCAA on LCFAs intestinal absorption. We investigate the distinction between healthy controls and liver cirrhosis with or without portal hypertension in LCFAs intestinal absorption. LCFAs intestinal absorption in patients with liver cirrhosis, especially these with portal hypertension, were significantly lower than in healthy control (p< 0.01). Molecular biological examination by small intestine biopsy specimens showed that the expression of FATP4 and I-FABP of liver cirrhosis with portal hypertension were significantly lower than those of healthy control respectively. BCAA improved LCFA absorption which were decreased due to liver cirrhosis. The possibility that BCAA improve LCFA small intestinal absorption in patients with liver cirrhosis was suggested.
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