PPAR-alpha mediated molecular mechanisms involved in spontaneous hepatocarcinogenesis among NASH mouse model
Project/Area Number |
15K09010
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Kochi University |
Principal Investigator |
SAIBARA Toshiji 高知大学, 教育研究部医療学系臨床医学部門, 教授 (60145125)
|
Co-Investigator(Kenkyū-buntansha) |
耕崎 拓大 高知大学, 教育研究部医療学系臨床医学部門, 講師 (00332833)
戸田 勝巳 高知大学, 教育研究部医療学系基礎医学部門, 准教授 (40197893)
水田 洋 高知大学, 教育研究部医療学系臨床医学部門, 助教 (70527605)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | PPAR-alpha / melanocortin receptor / insulin resistance / fatty liver / IL-6 / NASH / hepatocellular carcinoma / knockout mouse / Melanocortin receptor / 肝硬変 / 肝細胞癌 / MC4R / ノックアウトマウス |
Outline of Final Research Achievements |
Both MC4R KO mouse and MC4R-PPAR-alpha double KO mouse showed progressive impairment of insulin sensitivity and enhanced mRNA expression of genes involved in fatty acid synthesis, fatty acid beta and omega oxidation, inflammation, and scavenger receptors in addition to IL-6 mRNA. However, there was a significant difference in neoplastic nodule size and number among these two KO mice, i.e., averaged diameter and averaged number of tumor were significantly fewer in MC4R-PPAR-alpha double KO mouse than in MC4R KO mouse. This observation suggests that PPAR-alpha mediated mechanisms are involved in spontaneous hepatocarcinogenesis among NASH mouse models.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Prevalence of pruritus in patients with chronic liver disease: a multicenter study2018
Author(s)
Oeda S, Takahashi H, Yoshida H, Ogawa Y, Imajo K, Yoneda M, Koshiyama Y, Ono M, Hyogo H, Kawaguchi T, Fujii H, Nishino K, Sumida Y, Tanaka S, Kawanaka M, Torimura T, Saibara T, Kawaguchi A, Nakajima A, Eguchi Y; Japan Study Group for NAFLD (JSG-NAFLD)
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Journal Title
Hepatol Res
Volume: 48
Pages: E252-E262
DOI
Related Report
Peer Reviewed
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[Journal Article] Evaluation of postprandial hypoglycemia in patients with nonalcoholic fatty liver disease by oral glucose tolerance testing and continuous glucose monitoring2018
Author(s)
Oki Y, Ono M, Hyogo H, Ochi T, Munekage K, Nozaki Y, Hirose A, Masuda K, Mizuta H, Okamoto N, Saibara T
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Journal Title
Eur J Gastroenterol Hepatol
Volume: -
Pages: -
DOI
Related Report
Peer Reviewed
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[Journal Article] The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study2018
Author(s)
Ishiba H, Sumida Y, Tanaka S, Yoneda M, Hyogo H, Ono M, Fujii H, Eguchi Y, Suzuki Y, Yoneda M, Takahashi H, Nakahara T, Seko Y, Mori K, Kanemasa K, Shimada K, Imai S, Imajo K, Kawaguchi T, Nakajima A, Chayama K, Saibara T、 Shima T, Fujimoto K, Okanoue T, Itoh Y
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Journal Title
J Gastroenterol
Volume: -
Pages: -
DOI
Related Report
Peer Reviewed
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[Journal Article] Abnormal lipid/ lipoprotein metabolism and high plasma testosterone levels in male but not female aromatase-knockout mice2017
Author(s)
Amano A, Kondo Y, Noda Y, Ohta M, Kawanishi N, Machida S, Mitsuhashi K, Senmaru T, Fukui M, Takaoka O, Mori T, Kitawaki J, Ono M, Saibara T, Obayashi H, Ishigami A
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Journal Title
Arch Biochem Biophys
Volume: 622
Pages: 47-58
DOI
Related Report
Peer Reviewed
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[Journal Article] Differences in characteristics of glucose intolerance between patients with NAFLD and chronic hepatitis C as determined by CGMS2017
Author(s)
Ochi T, Kawaguchi T, Nakahara T, Ono M, Noguchi S, Koshiyama Y, Munekage K, Murakami E, Hiramatsu A, Ogasawara M, Hirose A, Mizuta H, Masuda K, Okamoto N, Suganuma N, Chayama K, Yamaguchi M, Torimura T, Saibara T
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Journal Title
Sci Rep
Volume: 7
Pages: 10146
DOI
Related Report
Peer Reviewed
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[Journal Article] Patatin-like phospholipase domain-containing protein 3 is involved in hepatic fatty acid and triglyceride metabolism through X-box binding protein 1 and modulation of endoplasmic reticulum stress in mice.2016
Author(s)
Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T.
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Journal Title
Hepatol Res
Volume: 46
Pages: 584-92
DOI
Related Report
Peer Reviewed
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[Journal Article] A successful case of deceased donor liver transplantation for a patient with intrahepatic arterioportal fistula.2016
Author(s)
Takagi K, Yagi T, Yoshida R, Shinoura S, Umeda Y, Nobuoka D, Watanabe N, Kuise T, Sui K, Hirose A, Tsuboi M, Ogasawara M, Iwasaki S, Saibara T, Fujiwara T.
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Journal Title
Hepatol Res
Volume: 46
Pages: 1409-1415
DOI
Related Report
Peer Reviewed
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[Journal Article] CCDC88A, a prognostic factor for human pancreatic cancers, promotes the motility and invasiveness of pancreatic cancer cells2016
Author(s)
Tanouchi A, Taniuchi K, Furihata M, Naganuma S, Dabanaka K, Kimura M, Watanabe R, Kohsaki T, Shimizu T, Saito M, Hanazaki K, Saibara T.
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Journal Title
J Exp Clin Cancer Res
Volume: 35
Pages: 190
DOI
Related Report
Peer Reviewed
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[Journal Article] Vav3 is linked to poor prognosis of pancreatic cancers and promotes the motility and invasiveness of pancreatic cancer cells.2016
Author(s)
Tsuboi M, Taniuchi K, Furihata M, Naganuma S, Kimura M, Watanabe R, Shimizu T, Saito M, Dabanaka K, Hanazaki K, Saibara T.
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Journal Title
Pancreatology
Volume: 16
Pages: 905-16
DOI
Related Report
Peer Reviewed
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[Journal Article] PNPLA3 is involved in hepatic fatty acid and triglyceride metabolism through XBP1 and modulation of endoplasmic reticulum stress in mice.2016
Author(s)
Ochi T, Munekage K, Ono M, Higuchi T, Tsuda M, Hayashi Y, Okamoto N, Toda K, Sakamoto S, Oben JA, Saibara T
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Journal Title
Hepatol Res.
Volume: -
Pages: 印刷中
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis.2015
Author(s)
Watanabe S, Hashimoto E, Ikejima K, Uto H, Ono M, Sumida Y, Seike M, Takei Y, Takehara T, Tokushige K, Nakajima A, Yoneda M, Saibara T,Shiota G, Sakaida I, Nakamuta M, Mizuta T, Tsubouchi H, Sugano K, Shimosegawa T
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Journal Title
J Gastroenterol.
Volume: 50
Pages: 364-77
DOI
Related Report
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