Elucidation of the association of locomotive syndrome in chronic liver disease

• Project/Area Number: 15K09011
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagasaki University
• Principal Investigator: TAURA Naota 長崎大学, 病院(医学系), 助教 (40380860)
• Co-Investigator(Kenkyū-buntansha): 有馬 和彦 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ケトン体 / ロコモティブシンドローム / 骨格筋量 / 慢性肝疾患症例登録

Outline of Final Research Achievements

OBJECTIVE:We investigated whether prognosis of patients with HCC after transcatheter arterial chemoembolization (TACE) was associated with venous blood ketone bodies. METHODS:Sixty-eight patients with HCC who underwent TACE were recruited for this study. RESULTS:The cumulative survival rate of patients with total ketone body ratio ([TKBR]: posttreatment/pretreatment total ketone bodies) <1 was 86.6%. The rate with TKBR was 59.0% at 300 d. Cox regression analysis identified the TKBR that independently and significantly predicted the patients' prognoses. Logistic regression analysis revealed the IMAC that predicted TKBR. TKBR and IMAC were positively correlated. CONCLUSIONS: The venous ketone bodies could be a new predictor of the prognosis of HCC patients after TACE.

Research Products

• [Journal Article] Ketone bodies as a predictor of prognosis of hepatocellular carcinoma after transcatheter arterial chemoembolization (2018)
  • Author(s): Sasaki Ryu、Taura Naota、Miyazoe Yuri、Yamamichi Shinobu、Nakashiki Suguru、Yamashima Mio、Suehiro Tomoyuki、Honda Takuya、Shibata Hidetaka、Ozawa Eisuke、Miuma Satoshi、Akazawa Yuko、Miyaaki Hisamitsu、Matsumoto Takehiro、Nakao Kazuhiko、Ashizawa Kazuto
  • Journal Title: Nutrition Volume: 50 Pages: 97-103
  • DOI: 10.1016/j.nut.2017.12.015
  • NAID: 120006988032
  • Peer Reviewed / Open Access
• [Presentation] 肝癌治療における静脈血中ケトン体と骨格筋の関連 (2017)
  • Author(s): 佐々木 龍, 田浦 直太，中尾 一彦
  • Organizer: JDDW2017