| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we investigated the impact of HBV infection on the induction of type I and type III interferon (IFN) by stimulation of intracellular nucleic acid sensors in the hepatocytes. A HBV-permissive cell line, Hep G2-NTCP, was infected with HBV and transfected with double-strand RNA to activate nucleic acid sensors. Interestingly the induction of type I/III IFNs was significantly suppressed in the HBV-infected cells. Oh the other hand, the amounts of intracellular HBV mRNAs and extracellular viral antigen were greatly reduced in the double-strand RNA-treated group in the absence of IFNs, Thus, the activation of nucleic acid sensors induces uncharacterized antiviral pathways independent of conventional type I/III interferon signaling.
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