Hepatic pathology of patients achieved sustained hepatitis C viral response
Project/Area Number |
15K09019
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
|
Research Institution | Osaka City University |
Principal Investigator |
TAMORI Akihiro 大阪市立大学, 大学院医学研究科, 准教授 (30291595)
|
Co-Investigator(Kenkyū-buntansha) |
村上 善基 大阪市立大学, 大学院医学研究科, 准教授 (00397556)
榎本 大 大阪市立大学, 大学院医学研究科, 准教授 (20423874)
大藤 さとこ 大阪市立大学, 大学院医学研究科, 准教授 (70433290)
久保 正二 大阪市立大学, 大学院医学研究科, 准教授 (80221224)
|
Co-Investigator(Renkei-kenkyūsha) |
HOANG Hai 大阪市立大学, 大学院医学研究科, 研究員 (60623246)
|
Project Period (FY) |
2015-10-21 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | C型肝炎ウイルス / 肝発癌 / SVR / マイクロRNA |
Outline of Final Research Achievements |
We examined the pathology in liver after eradication of hepatitis C virus (HCV) by anti-viral therapy. First of all, single nucleotide polymorphisms (SNPs) were analyzed in patients with HCV. Our data suggested that MICA minor genotype was significantly associated with prevalence of hepatocellular carcinoma (HCC) in patients with HCV. On the other hand, there was no significant associated SNPs with HCC in patients achieved sustained viral response by direct acting anti-virals. In patients achieved sustained viral response by interferon-based therapy, histological stagnation of hepatic fibrosis improvement was related to hepatocarcinogenesis. Immunohistochemical analysis showed that activated stellate cells persistently existed in non-cancerous liver tissue. It was speculated that continuously activated stellated cells might played an important role in SVR-HCC, and continuous hepatic fibrosis.
|
Report
(4 results)
Research Products
(26 results)
-
[Journal Article] Stagnation of histopathological improvement is a predictor of hepatocellular carcinoma development after hepatitis C virus eradication.2018
Author(s)
Motoyama H, Tamori A, Kubo S, Uchida-Kobayashi S, Takemura S, Tanaka S, Ohfuji S, Teranishi Y, Kozuka R, Kawamura E, Hagihara A, Morikawa H, Enomoto M, Murakami Y, Kawada N.
-
Journal Title
PLoS One.
Volume: 13
Issue: 3
Pages: 0194163-0194163
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
-
-
-
[Journal Article] 4.Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with HCV genotype 1b2016
Author(s)
Tamori A, Yoshida K, Kurai O, Kioka K, Hai H, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N
-
Journal Title
Hepatol Res.
Volume: 46
Issue: 8
Pages: 1311-1320
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] Randomized trial of combined triple therapy comprising two types of peginterferon with simeprevir in patients with HCV genotype 1b.2016
Author(s)
Tamori A, Yoshida K, Kurai O, Kioka K, Hai H, Kozuka R, Motoyama H, Kawamura E, Hagihara A, Uchida-Kobayashi S, Morikawa H, Enomoto M, Murakami Y, Kawada N.
-
Journal Title
Hepatol Res
Volume: 印刷中
Issue: 13
Pages: 1311-1320
DOI
Related Report
Peer Reviewed / Int'l Joint Research
-
-
-
-
-
-
-
-
-
[Presentation] Efficacy and safety of sofobuvir based therapies for cirrhotic and/or elder patients with hepatitis C virus in Japanese real world2016
Author(s)
A.Tamori, R.Kozuka, S.Uchida-Kobayashi, M.Enomoto,Y.Teranishi, H.Motoyam, E.Kawamura,A.Hagihara, Y.Murakami, H.Hai,H.Oka, N.Kawada
Organizer
67th American Association for the study of liver diseases
Place of Presentation
ボストン(アメリカ合衆国)
Year and Date
2016-11-12
Related Report
Int'l Joint Research
-
[Presentation] Combination therapy with daclatasvir and asunaprevir in cirrhotic and non-cirrhotic patients with hepatitis C virus genotype 1b in Japan2016
Author(s)
A. Tamori, M. Enomoto, S. Kobayashi-Uchida, H. Hai, Y. Teranishi, H. Motoyama, R. Kozuka, E. Kawamura, A. Hagihara, Y. Murakami, N. Kawada
Organizer
4th European Gastroenterology
Place of Presentation
ウイーン(オーストリア)
Year and Date
2016-10-15
Related Report
Int'l Joint Research
-
-
-
-
-
-
[Presentation] MICA SNP, but not DEPDC5, PNPLA3 and HCP5 SNPs, is associated with chronic hepatitis C-related hepatocellular carcinoma2015
Author(s)
H. Hai, A. Tamori, K. Yoshida, A. Hagihara, E. Kawamura, S.K. Uchida, H. Morikawa, M. Enomoto, Y. Murakami, T.T. Le, N. Kawada
Organizer
66th American Association for the study of liver diseases
Place of Presentation
サンフランシスコ( アメリカ合衆国 )
Year and Date
2015-11-17
Related Report
Int'l Joint Research
-
[Presentation] MicroRNA expression in hepatocellular carcinoma and non-cancerous livers after the eradication of hepatitis virus C using interferon-based therap2015
Author(s)
A Tamori, Y Murakami, S Kubo, S Itami, S Uchida-Kobayashi, H Morikawa, M Enomoto, S Takemura, T Tanahashi, Y-h Taguchi, N Kawada
Organizer
66th American Association for the study of liver diseases
Place of Presentation
サンフランシスコ( アメリカ合衆国 )
Year and Date
2015-11-14
Related Report
Int'l Joint Research