| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The main cause of hepatocarcinogenesis in Japan has been changing from viral infection to fatty liver diseases. The hepatic pathogenesis in fatty liver diseases is considered to be induced by dietary environmental change and this fact indicated that epigenetic change is an important factor in this disease entity. We refined Nrf-2, EZH2 and microRNA-122 as pathogenetic factors from the analyses of HCV particle producing cell line HPI and a murine model STAM. Moreover, we focused on a C57BL/6 model which develops hepatoma with only a high fat diet without giving any chemical carcinogens, and obtained an important result from this murine model that a component change of bile acids metabolized by intestinal microbiota and a consequent activation of mTOR pathway were most notable pathogenetic factors. Nrf-2, EZH2 and microRNA were also changed in this model, and these results reflected in vitro aspects.
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