| Project/Area Number |
15K09023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山科 俊平 順天堂大学, 医学部, 准教授 (30338412)
今 一義 順天堂大学, 医学部, 准教授 (30398672)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKEDA Kazuyoshi 順天堂大学, 医学(系)研究科(研究院), 准教授 (80272821)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 非アルコール性脂肪肝炎（NASH） / 自然免疫 / NKT細胞 / 腸内マイクロバイオーム / アミノ酸 / 免疫栄養 / 耐糖能異常 / 非アルコール性脂肪肝炎（NASH) / 糖代謝 / インスリン / 腸内細菌叢 / RIG-I / メタボリックシンドローム |
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| Outline of Final Research Achievements |
In this study, we investigated the role of innate immune responses in metabolic steatohepatitis (MetSH), and evaluate the protective effect of amino acid on MetSH.In MetSH model KK-Ay mice, glycine ameliorated glucose intolerance, accompanied with changes in gut microbiota. Progressive depletion of hepatic NK and NKT cells, in combination with increases in myeloid suppressor cells, were observed in hepatocyte-specific Pten-KO mice, which spontaneously develop steatohepatitis and hepatocellular adenoma/carcinoma upon aging. Glycine also prevented steatohepatitis and tumorigenesis in Pten-KO mice. These findings clearly indicated that pharmaco-nutritional approach utilizing glycine is promising for prevention and treatment of MetSH including MetSH-related carcinogenesis.
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