| Project/Area Number |
15K09026
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Tokyo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
本多 彰 東京医科大学, 医学部, 教授 (10468639)
池上 正 東京医科大学, 医学部, 教授 (40439740)
宮崎 照雄 東京医科大学, 医学部, 講師 (60532687)
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
|
|---|
| Keywords | 慢性肝疾患 / マイオカイン / 分岐鎖アミノ酸 |
|---|
| Outline of Final Research Achievements |
Skeletal muscles secrete myokines that have physiological actions in response to muscle contractions, and some intermediates of branched-chain amino acids (BCAAs) during energy production. This study evaluated the physiological actions of the BCAA-intermediates as myokines on the hepatic metabolism in cultured hepatocytes and rat hepatic tissue. Leucine-intermediate 3-hydroxy-3-methylbutyrate and valine 3-hydroxyisobutyrate had the increase of reduced albumin synthesis ability and the inhibition of ketone body production, respectively, although the effect of valine intermediate 3-aminoisobutyrate on the hepatic lipid catabolism had not been confirmed.
|
