The actions of BCAA intermediates as myokines on hepatic metabolism
| Project/Area Number |
15K09026
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
本多 彰 東京医科大学, 医学部, 教授 (10468639)
池上 正 東京医科大学, 医学部, 教授 (40439740)
宮崎 照雄 東京医科大学, 医学部, 講師 (60532687)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 慢性肝疾患 / マイオカイン / 分岐鎖アミノ酸 |
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| Outline of Final Research Achievements |
Skeletal muscles secrete myokines that have physiological actions in response to muscle contractions, and some intermediates of branched-chain amino acids (BCAAs) during energy production. This study evaluated the physiological actions of the BCAA-intermediates as myokines on the hepatic metabolism in cultured hepatocytes and rat hepatic tissue. Leucine-intermediate 3-hydroxy-3-methylbutyrate and valine 3-hydroxyisobutyrate had the increase of reduced albumin synthesis ability and the inhibition of ketone body production, respectively, although the effect of valine intermediate 3-aminoisobutyrate on the hepatic lipid catabolism had not been confirmed.
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Report
(4 results)
Research Products
(12 results)
