Development of biomarker for sorafenib treatment using serum microRNA in patients with hepatocellular carcinoma

• Project/Area Number: 15K09028
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Kindai University
• Principal Investigator: KUDO Masatoshi 近畿大学, 医学部, 教授 (10298953)
• Co-Investigator(Kenkyū-buntansha): 西田 直生志 近畿大学, 医学部, 准教授 (60281755)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: マイクロRNA / ソラフェニブ / 肝細胞癌 / バイオマーカー / 分子標的療法 / 生存期間 / 化学療法 / BCLCステージ / 治療反応性 / マイクロRFA / エクソソーム

Outline of Final Research Achievements

The aim of this study was to clarify the specific miRNAs in serum that could predict the early response of HCC to sorafenib treatment.Analyzing the sera from screening cohort, we selected five miRNAs. Through further analysis using a validation cohort and healthy control subjects, we found that miR-181a-5p and miR-339-5p showed significant differences in serum levels among patients with partial response (PR), stable disease (SD), and progressive disease (PD). We also analyzed the factors associated with disease control (DC); patients with DC showed a significantly higher level of serum miR-181a-5p than non-DC patients or healthy control subjects. We further conducted multivariate analysis among HCC patients with Barcelona Clinic Liver Cancer stage C using extrahepatic metastasis, serum decarboxiprothrombin and miR-181a-5p levels as covariables; serum miR-181a-5p was the only independent factor for achieving DC and affecting overall survival.

Research Products

• [Journal Article] Transarterial Chemoembolization in Combination with a Molecular Targeted Agent: Lessons Learned from Negative Trials (Post-TACE, BRISK-TA, SPACE, ORIENTAL, and TACE-2) (2017)
  • Author(s): Kudo Masatoshi、Arizumi Tadaaki
  • Journal Title: Oncology Volume: 93 Issue: Suppl. 1 Pages: 127-134
  • DOI: 10.1159/000481243
  • Peer Reviewed / Open Access
• [Journal Article] Immuno-Oncology in Hepatocellular Carcinoma: 2017 Update (2017)
  • Author(s): Kudo Masatoshi
  • Journal Title: Oncology Volume: 93 Issue: Suppl. 1 Pages: 147-159
  • DOI: 10.1159/000481245
  • Peer Reviewed / Open Access
• [Journal Article] Systemic Therapy for Hepatocellular Carcinoma: 2017 Update (2017)
  • Author(s): Kudo Masatoshi
  • Journal Title: Oncology Volume: 93 Issue: Suppl. 1 Pages: 135-146
  • DOI: 10.1159/000481244
  • Peer Reviewed / Open Access
• [Journal Article] Validation and Potential of Albumin-Bilirubin Grade and Prognostication in a Nationwide Survey of 46,681 Hepatocellular Carcinoma Patients in Japan: The Need for a More Detailed Evaluation of Hepatic Function (2017)
  • Author(s): Hiraoka Atsushi、Michitaka Kojiro、Kumada Takashi、Izumi Namiki、Kadoya Masumi、Kokudo Norihiro、Kubo Shoji、Matsuyama Yutaka、Nakashima Osamu、Sakamoto Michiie、Takayama Tadatoshi、Kokudo Takashi、Kashiwabara Kosuke、Kudo Masatoshi、The Liver Cancer Study Group of Japan
  • Journal Title: Liver Cancer Volume: 6 Issue: 4 Pages: 325-336
  • DOI: 10.1159/000479984
  • Peer Reviewed / Open Access
• [Journal Article] Treatment Stage Migration Maximizes Survival Outcomes in Patients with Hepatocellular Carcinoma Treated with Sorafenib: An Observational Study (2017)
  • Author(s): Yen Clarence、Sharma Rohini、Rimassa Lorenza、Arizumi Tadaaki、Bettinger Dominik、Choo Huay Yee、Pressiani Tiziana、Burlone Michela E.、Pirisi Mario、Giordano Laura、Abdulrahman Anisa、Kudo Masatoshi、Thimme Robert、Park Joong Won、Pinato David James
  • Journal Title: Liver Cancer Volume: 6 Issue: 4 Pages: 313-324
  • DOI: 10.1159/000480441
  • Peer Reviewed / Open Access
• [Journal Article] Lenvatinib in Advanced Hepatocellular Carcinoma (2017)
  • Author(s): Kudo Masatoshi
  • Journal Title: Liver Cancer Volume: 6 Issue: 4 Pages: 253-263
  • DOI: 10.1159/000479573
  • Peer Reviewed / Open Access
• [Journal Article] Ultrasound-ultrasound image overlay fusion improves real-time control of radiofrequency ablation margin in the treatment of hepatocellular carcinoma (2017)
  • Author(s): Minami Yasunori、Minami Tomohiro、Hagiwara Satoru、Ida Hiroshi、Ueshima Kazuomi、Nishida Naoshi、Murakami Takamichi、Kudo Masatoshi
  • Journal Title: European Radiology Volume: 28 Issue: 5 Pages: 1986-1993
  • DOI: 10.1007/s00330-017-5162-8
  • Peer Reviewed
• [Journal Article] Hepatic Function during Repeated TACE Procedures and Prognosis after Introducing Sorafenib in Patients with Unresectable Hepatocellular Carcinoma: Multicenter Analysis (2017)
  • Author(s): Hiraoka Atsushi、Kumada Takashi、Kudo Masatoshi、Hirooka Masashi、Koizumi Yohei、Hiasa Yoichi、Tajiri Kazuto、Toyoda Hidenori、Tada Toshifumi、Ochi Hironori、Joko Koji、Shimada Noritomo、Deguchi Akihiro、Ishikawa Toru、Imai Michitaka、Tsuji Kunihiko、Michitaka Kojiro
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 602-610
  • DOI: 10.1159/000480256
  • Peer Reviewed
• [Journal Article] Role of Immune Checkpoint Blockade in the Treatment for Human Hepatocellular Carcinoma (2017)
  • Author(s): Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Dig. Dis Volume: 35 Issue: 6 Pages: 618-622
  • DOI: 10.1159/000480258
  • Peer Reviewed
• [Journal Article] Sorafenib-Regorafenib Sequential Therapy in Advanced Hepatocellular Carcinoma: A Single-Institute Experience (2017)
  • Author(s): Ueshima Kazuomi、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 611-617
  • DOI: 10.1159/000480257
  • Peer Reviewed
• [Journal Article] Time to Transcatheter Arterial Chemoembolization Refractoriness in Patients with Hepatocellular Carcinoma in Kinki Criteria Stages B1 and B2 (2017)
  • Author(s): Arizumi Tadaaki、Minami Tomohiro、Chishina Hirokazu、Kono Masashi、Takita Masahiro、Yada Norihisa、Hagiwara Satoru、Minami Yasunori、Ida Hiroshi、Ueshima Kazuomi、Kamata Ken、Minaga Kosuke、Komeda Yoriaki、Takenaka Mamoru、Sakurai Toshiharu、Watanabe Tomohiro、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 589-597
  • DOI: 10.1159/000480208
  • Peer Reviewed
• [Journal Article] Impact of Tumor Factors on Survival in Patients with Hepatocellular Carcinoma Classified Based on Kinki Criteria Stage B2 (2017)
  • Author(s): Arizumi Tadaaki、Minami Tomohiro、Chishina Hirokazu、Kono Masashi、Takita Masahiro、Yada Norihisa、Hagiwara Satoru、Minami Yasunori、Ida Hiroshi、Ueshima Kazuomi、Kamata Ken、Minaga Kosuke、Komeda Yoriaki、Takenaka Mamoru、Sakurai Toshiharu、Watanabe Tomohiro、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 583-588
  • DOI: 10.1159/000480186
  • Peer Reviewed
• [Journal Article] Hepatocarcinogenesis Is Associated with Serum Albumin Levels after Sustained Virological Responses with Interferon-Based Therapy in Patients with Hepatitis C (2017)
  • Author(s): Umehara Yasuko、Hagiwara Satoru、Nishida Naoshi、Sakurai Toshiharu、Ida Hiroshi、Minami Yasunori、Takita Masahiro、Minami Tomohiro、Chishina Hirokazu、Ueshima Kazuomi、Komeda Yoriaki、Arizumi Tadaaki、Watanabe Tomohiro、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 548-555
  • DOI: 10.1159/000480147
  • Peer Reviewed
• [Journal Article] Diagnosis of Fibrosis and Activity by a Combined Use of Strain and Shear Wave Imaging in Patients with Liver Disease (2017)
  • Author(s): Yada Norihisa、Tamaki Nobuhura、Koizumi Yohei、Hirooka Masashi、Nakashima Osamu、Hiasa Yoichi、Izumi Namiki、Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 515-520
  • DOI: 10.1159/000480140
  • Peer Reviewed
• [Journal Article] New Era of the Management of Liver Diseases and Liver Cancer: State-of-the-Art Progress in 2017 (2017)
  • Author(s): Kudo Masatoshi
  • Journal Title: Dig. Dis. Volume: 35 Issue: 6 Pages: 493-497
  • DOI: 10.1159/000480137
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Advanced Age on Survival in Patients Undergoing Resection of Hepatocellular Carcinoma (2017)
  • Author(s): Kaibori Masaki、Yoshii Kengo、Yokota Isao、Hasegawa Kiyoshi、Nagashima Fumio、Kubo Shoji、Kon Masanori、Izumi Namiki、Kadoya Masumi、Kudo Masatoshi、Kumada Takashi、Sakamoto Michiie、Nakashima Osamu、Matsuyama Yutaka、Takayama Tadatoshi、Kokudo Norihiro
  • Journal Title: Ann Surg Volume: 15 Issue: 4 Pages: 1-1
  • DOI: 10.1097/sla.0000000000002526
  • Peer Reviewed
• [Journal Article] Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesis (2017)
  • Author(s): Hagiwara Satoru、Nishida Naoshi、Park Ah-Mee、Komeda Yoriaki、Sakurai Toshiharu、Watanabe Tomohiro、Kudo Masatoshi
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 10440-10440
  • DOI: 10.1038/s41598-017-10570-0
  • Peer Reviewed / Open Access
• [Journal Article] Gankyrin induces STAT3 activation in tumor microenvironment and sorafenib resistance in hepatocellular carcinoma. (2017)
  • Author(s): Sakurai T, Yada N, Hagiwara S, Arizumi T, Minaga K, Kamata K, Takenaka M, Minami Y, Watanabe T, Nishida N, Kudo M.
  • Journal Title: Cancer Sci. Volume: １０８ Issue: 10 Pages: 1996-2003
  • DOI: 10.1111/cas.13341
  • Peer Reviewed / Open Access
• [Journal Article] The Overall Survival of Patients with Hepatocellular Carcinoma Correlates with the Newly Defined Time to Progression after Transarterial Chemoembolization (2017)
  • Author(s): Arizumi Tadaaki、Ueshima Kazuomi、Iwanishi Mina、Minami Tomohiro、Chishina Hirokazu、Kono Masashi、Takita Masahiro、Yada Norihisa、Hagiwara Satoru、Minami Yasunori、Ida Hiroshi、Komeda Yoriaki、Takenaka Mamoru、Sakurai Toshiharu、Watanabe Tomohiro、Nishida Naoshi、Kudo Masatoshi
  • Journal Title: Liver Cancer Volume: 6 Issue: 3 Pages: 227-235
  • DOI: 10.1159/000475777
  • Peer Reviewed / Open Access
• [Journal Article] Albumin-Bilirubin Grade and Hepatocellular Carcinoma Treatment Algorithm (2017)
  • Author(s): Kudo Masatoshi
  • Journal Title: Liver Cancer Volume: 6 Issue: 3 Pages: 185-188
  • DOI: 10.1159/000462199
  • Peer Reviewed
• [Journal Article] S-1 versus placebo in patients with sorafenib-refractory advanced hepatocellular carcinoma (S-CUBE): a randomised, double-blind, multicentre, phase 3 trial (2017)
  • Author(s): Kudo Masatoshi、Moriguchi Michihisa、Numata Kazushi、Hidaka Hisashi、Tanaka Hironori、Ikeda Masafumi、Kawazoe Seiji、Ohkawa Shinichi、Sato Yozo、Kaneko Shuichi、Furuse Junji、Takeuchi Madoka、Fang Xuemin、Date Yoshito、Takeuchi Masahiro、Okusaka Takuji
  • Journal Title: Lancet Gastroenterol Hepatol. Volume: 2 Issue: 6 Pages: 407-417
  • DOI: 10.1016/s2468-1253(17)30072-9
  • Peer Reviewed
• [Journal Article] Liver resection for hepatocellular carcinoma associated with hepatic vein invasion: A Japanese nationwide survey (2017)
  • Author(s): Kokudo Takashi、Hasegawa Kiyoshi、Matsuyama Yutaka、Takayama Tadatoshi、Izumi Namiki、Kadoya Masumi、Kudo Masatoshi、Kubo Shoji、Sakamoto Michiie、Nakashima Osamu、Kumada Takashi、Kokudo Norihiro、for the Liver Cancer Study Group of Japan
  • Journal Title: Hepatology Volume: 66 Issue: 2 Pages: 510-517
  • DOI: 10.1002/hep.29225
  • Peer Reviewed
• [Journal Article] Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial (2017)
  • Author(s): El-Khoueiry Anthony B、Sangro Bruno、Yau Thomas、Crocenzi Todd S、Kudo Masatoshi、Hsu Chiun、Kim Tae-You、Choo Su-Pin、Trojan J?rg、Welling Theodore H、Meyer Tim、Kang Yoon-Koo、Yeo Winnie、Chopra Akhil、Anderson Jeffrey、dela Cruz Christine、Lang Lixin、Neely Jaclyn、Tang Hao、Dastani Homa B、Melero Ignacio
  • Journal Title: Lancet Volume: 389 Issue: 10088 Pages: 2492-2502
  • DOI: 10.1016/s0140-6736(17)31046-2
  • Peer Reviewed
• [Journal Article] MicroRNAs for the Prediction of Early Response to Sorafenib Treatment in Human Hepatocellular Carcinoma. (2017)
  • Author(s): Nishida N, Arizumi T, Hagiwara S, Ida H, Sakurai T, Kudo M.
  • Journal Title: Liver Cancer Volume: 6 Issue: 2 Pages: 113-125
  • DOI: 10.1159/000449475
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of Epigenetic Alterations in Human Hepatocellular Carcinoma and Its Association with Genetic Mutations. (2016)
  • Author(s): Nishida N, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 708-713
  • DOI: 10.1159/000448863
  • Peer Reviewed / Open Access
• [Journal Article] 1.2.Impact of Tight Junction Protein ZO-1 and TWIST Expression on Postoperative Survival of Patients with Hepatocellular Carcinoma. (2016)
  • Author(s): Nagai T, Arao T, Nishio K, Matsumoto K, Hagiwara S, Sakurai T, Minami Y, Ida H, Ueshima K, Nishida N, Sakai K, Saijo N, Kudo K, Kaneda H, Tamura D, Aomatsu K, Kimura H, Fujita Y, Haji S, Kudo M.
  • Journal Title: Dig Dis. Volume: 34 Issue: 6 Pages: 702-707
  • DOI: 10.1159/000448860
  • Peer Reviewed / Open Access
• [Journal Article] US-US Fusion Imaging in Radiofrequency Ablation for Liver Metastases. (2016)
  • Author(s): Minami Y, Minami T, Chishina H, Kono M, Arizumi T, Takita M, Yada N, Hagiwara S, Ida H, Ueshima K, Nishida N, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 687-691
  • DOI: 10.1159/000448857
  • Peer Reviewed / Open Access
• [Journal Article] Cases with Refractory Ascites and a Delayed Response to Tolvaptan (2016)
  • Author(s): Hagiwara S, Nishida N, Chishina H, Ida H, Sakurai T, Komeda Y, Kitano M, Kudo M.
  • Journal Title: Internal Medicine Volume: 55 Issue: 22 Pages: 3273-3277
  • DOI: 10.2169/internalmedicine.55.7035
  • NAID: 130005281923
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Journal Article] Validation of Kinki Criteria, a Modified Substaging System, in Patients with Intermediate Stage Hepatocellular Carcinoma. (2016)
  • Author(s): Arizumi T, Ueshima K, Iwanishi M, Minami T, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Minami Y, Ida H, Sakurai T, Kitano M, Nishida N, Kudo M
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 671-678
  • DOI: 10.1159/000448834
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Factors Predicting the Effect of Tolvaptan for Refractory Ascites in Patients with Decompensated Liver Cirrhosis. (2016)
  • Author(s): Chishina H, Hagiwara S, Nishida N, Ueshima K, Sakurai T, Ida H, Minami Y, Takita M, Kono M, Minami T, Iwanishi M, Umehara Y, Watanabe T, Komeda Y, Arizumi T, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 659-664
  • DOI: 10.1159/000448828
  • Peer Reviewed / Open Access
• [Journal Article] Prospective Risk Analysis of Hepatocellular Carcinoma in Patients with Chronic Hepatitis C by Ultrasound Strain Elastography. (2016)
  • Author(s): Yada N, Sakurai T, Minami T, Arizumi T, Takita M, Hagiwara S, Ida H, Ueshima K, Nishida N, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 650-653
  • DOI: 10.1159/000448865
  • Peer Reviewed / Open Access
• [Journal Article] Safety, Tolerability, and Efficacy of Sofosbuvir Plus Ribavirin in Elderly Patients Infected with Hepatitis C Virus Genotype 2. (2016)
  • Author(s): Nishida N, Kono M, Minami T, Chishina H, Arizumi T, Takita M, Yada N, Ida H, Hagiwara S, Minami Y, Ueshima K, Sakurai T, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 632-639
  • DOI: 10.1159/000448824
  • Peer Reviewed / Open Access
• [Journal Article] Outcome of Asunaprevir/Daclatasvir Combination Therapy for Chronic Liver Disease Type C. (2016)
  • Author(s): Hagiwara S, Nishida N, Watanabe T, Sakurai T, Ida H, Minami Y, Takita M, Minami T, Iwanishi M, Chishina H, Ueshima K, Komeda Y, Arizumi T, Kudo M.
  • Journal Title: Dig Dis Volume: 34 Issue: 6 Pages: 620-626
  • DOI: 10.1159/000448822
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of anti-migration properties of biliary covered self-expandable metal stents. (2016)
  • Author(s): Minaga K, Kitano M, Imai H, Harwani Y, Yamao K, Kamata K, Miyata T, Omoto S, Kadosaka K, Sakurai T, Nishida N, Kudo M.
  • Journal Title: World J Gastroenterol Volume: 22 Issue: 30 Pages: 6917-24
  • DOI: 10.3748/wjg.v22.i30.6917
  • Peer Reviewed / Open Access
• [Journal Article] Survival Benefit of Locoregional Treatment for Hepatocellular Carcinoma with Advanced Liver Cirrhosis. (2016)
  • Author(s): Kitai S, Kudo M, Nishida N, Izumi N, Sakamoto M, Matsuyama Y, Ichida T, Nakashima O, Matsui O, Ku Y, Kokudo N, Makuuchi M; Liver Cancer Study Group of Japan.
  • Journal Title: Liver Cancer Volume: 5 Issue: 3 Pages: 175-89
  • DOI: 10.1159/000367765
  • Peer Reviewed / Open Access
• [Journal Article] Epigenetic regulation and development of hepatocellular carcinoma (2016)
  • Author(s): Nishida N1, Kudo M.
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi Volume: 113 Issue: 5 Pages: 775-784
  • DOI: 10.11405/nisshoshi.113.775
  • NAID: 130005150380
  • ISSN: 0446-6586, 1349-7693
  • Peer Reviewed
• [Journal Article] Unique features associated with hepatic oxidative DNA damage and DNA methylation in non-alcoholic fatty liver disease. (2016)
  • Author(s): Nishida N, Yada N, Hagiwara S, Sakurai T, Kitano M, Kudo M.
  • Journal Title: J Gastroenterol Hepatol Volume: 31 Issue: 9 Pages: 1646-53
  • DOI: 10.1111/jgh.13318
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of Sorafenib in Patients with Transcatheter Arterial Chemoembolization (TACE) Refractory and Intermediate-Stage Hepatocellular Carcinoma. (2015)
  • Author(s): Arizumi T, Ueshima K, Minami T, Kono M, Chishina H, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Minami Y, Sakurai T, Nishida N, Kudo M.
  • Journal Title: Liver Cancer Volume: 4 Issue: 4 Pages: 253-62
  • DOI: 10.1159/000367743
  • Peer Reviewed
• [Journal Article] Validation of a Modified Substaging System (Kinki Criteria) for Patients with Intermediate-Stage Hepatocellular Carcinoma. (2015)
  • Author(s): Arizumi T, Ueshima K, Iwanishi M, Minami T, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Ida H, Minami Y, Sakurai T, Kitano M, Nishida N, Kudo M.
  • Journal Title: Oncology Volume: 89 Issue: Suppl. 2 Pages: 47-52
  • DOI: 10.1159/000440631
  • Peer Reviewed
• [Journal Article] Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A Single-Center Experience. (2015)
  • Author(s): Minami Y, Minami T, Chishina H, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Tsurusaki M, Yagyu Y, Ueshima K, Nishida N, Murakami T, Kudo M.
  • Journal Title: Oncology Volume: 89 Issue: Suppl. 2 Pages: 27-32
  • DOI: 10.1159/000440628
  • Peer Reviewed
• [Journal Article] Evaluation of ART Scores for Repeated Transarterial Chemoembolization in Japanese Patients with Hepatocellular Carcinoma. (2015)
  • Author(s): Arizumi T, Ueshima K, Iwanishi M, Minami T, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Ida H, Minami Y, Sakurai T, Nishida N, Kitano M, Kudo M.
  • Journal Title: Oncology Volume: 89 Issue: Suppl. 2 Pages: 4-10
  • DOI: 10.1159/000440625
  • Peer Reviewed
• [Journal Article] A Newly Developed Shear Wave Elastography Modality: With a Unique Reliability Index. (2015)
  • Author(s): Yada N, Sakurai T, Minami T, Arizumi T, Takita M, Hagiwara S, Ueshima K, Ida H, Nishida N, Kudo M.
  • Journal Title: Oncology Volume: 89 Issue: Suppl. 2 Pages: 53-9
  • DOI: 10.1159/000440632
  • Peer Reviewed
• [Journal Article] Cone-Beam CT Angiography for Hepatocellular Carcinoma: Current Status. (2015)
  • Author(s): Minami Y, Murakami T, Kitano M, Sakurai T, Nishida N, Kudo M.
  • Journal Title: Dig Dis. Volume: 33 Issue: 6 Pages: 759-64
  • DOI: 10.1159/000439100
  • Peer Reviewed
• [Journal Article] Hepatic DNA Methylation Is Affected by Hepatocellular Carcinoma Risk in Patients with and without Hepatitis Virus. (2015)
  • Author(s): Nishida N, Iwanishi M, Minami T, Chishina H, Arizumi T, Takita M, Kitai S, Yada N, Ida H, Hagiwara S, Minami Y, Ueshima K, Sakurai T, Kitano M, Kudo M.
  • Journal Title: Dig Dis Volume: 33 Issue: 6 Pages: 745-50
  • DOI: 10.1159/000439098
  • Peer Reviewed
• [Journal Article] Real-Life Clinical Practice with Sorafenib in Advanced Hepatocellular Carcinoma: A Single-Center Experience Second Analysis. (2015)
  • Author(s): Arizumi T, Ueshima K, Iwanishi M, Chishina H, Kono M, Takita M, Kitai S, Inoue T, Yada N, Hagiwara S, Ida H, Minami Y, Sakurai T, Nishida N, Kitano M, Kudo M.
  • Journal Title: Dig Dis. Volume: 33 Issue: 6 Pages: 728-34
  • DOI: 10.1159/000439079
  • Peer Reviewed
• [Journal Article] Subclassification of BCLC B Stage Hepatocellular Carcinoma and Treatment Strategies: Proposal of Modified Bolondi's Subclassification (Kinki Criteria). (2015)
  • Author(s): Kudo M, Arizumi T, Ueshima K, Sakurai T, Kitano M, Nishida N.
  • Journal Title: Dig Dis. Volume: 33 Issue: 6 Pages: 751-8
  • DOI: 10.1159/000439290
  • Peer Reviewed
• [Journal Article] Early Viral Response Predicts the Efficacy of Antiviral Triple Therapy with Simeprevir, Peg-Interferon and Ribavirin in Patients Infected with Hepatitis C Virus Genotype 1. (2015)
  • Author(s): Nishida N, Iwanishi M, Minami T, Chishina H, Arizumi T, Takita M, Kitai S, Yada N, Ida H, Hagiwara S, Minami Y, Ueshima K, Sakurai T, Kitano M, Kudo M.
  • Journal Title: Dig Dis. Volume: 33 Issue: 6 Pages: 708-14
  • DOI: 10.1159/000439075
  • Peer Reviewed
• [Journal Article] Challenges of Clinical Research on Hepatocellular Carcinoma. (2015)
  • Author(s): Kudo M, Kitano M, Sakurai T, Nishida N.
  • Journal Title: Dig Dis. Volume: 33 Issue: 6 Pages: 780-90
  • DOI: 10.1159/000439103
  • Peer Reviewed
• [Journal Article] Molecular Mechanism and Prediction of Sorafenib Chemoresistance in Human Hepatocellular Carcinoma. (2015)
  • Author(s): Nishida N, Kitano M, Sakurai T, Kudo M.
  • Journal Title: Dig Dis. Volume: 33 Issue: 6 Pages: 771-9
  • DOI: 10.1159/000439102
  • Peer Reviewed
• [Journal Article] General Rules for the Clinical and Pathological Study of Primary Liver Cancer, Nationwide Follow-Up Survey and Clinical Practice Guidelines: The Outstanding Achievements of the Liver Cancer Study Group of Japan. (2015)
  • Author(s): Kudo M, Kitano M, Sakurai T, Nishida N.
  • Journal Title: Dig Dis. Volume: 33 Issue: 6 Pages: 765-70
  • DOI: 10.1159/000439101
  • Peer Reviewed
• [Journal Article] Antiviral therapy for chronic hepatitis B: Combination of nucleoside analogs and interferon. (2015)
  • Author(s): Hagiwara S, Nishida N, Kudo M.
  • Journal Title: World J Hepatol. Volume: 7 Issue: 23 Pages: 2427-31
  • DOI: 10.4254/wjh.v7.i23.2427
  • Peer Reviewed
• [Journal Article] Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability. (2015)
  • Author(s): Toda K, Nagasaka T, Umeda Y, Tanaka T, Kawai T, Fuji T, Taniguchi F, Yasui K, Kubota N, Takehara Y, Tazawa H, Kagawa S, Sun DS, Nishida N, Goel A, Fujiwara T.
  • Journal Title: Clin Epigenetics Volume: 7 Issue: 1 Pages: 73-73
  • DOI: 10.1186/s13148-015-0096-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Serum miR-21, miR-29a, and miR-125b Are Promising Biomarkers for the Early Detection of Colorectal Neoplasia. (2015)
  • Author(s): Yamada A, Horimatsu T, Okugawa Y, Nishida N, Honjo H, Ida H, Kou T, Kusaka T, Sasaki Y, Yagi M, Higurashi T, Yukawa N, Amanuma Y, Kikuchi O, Muto M, Ueno Y, Nakajima A, Chiba T, Boland CR, Goel A.
  • Journal Title: Clin Cancer Res. Volume: 21 Issue: 18 Pages: 4234-42
  • DOI: 10.1158/1078-0432.ccr-14-2793
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] mpaired expression of ATP-binding cassette transporter G2 and liver damage in erythropoietic protoporphyria (2015)
  • Author(s): Hagiwara S, Nishida N, Park AM, Sakurai T, Kawada A
  • Journal Title: Hepatology Volume: 62 Issue: 5 Pages: 1638-1639
  • DOI: 10.1002/hep.27871
  • Peer Reviewed / Open Access
• [Journal Article] A bridge between multi-omics data and the management of hepatocellular carcinoma. (2015)
  • Author(s): Nishida N, Kudo M.
  • Journal Title: Ann Transl Med Volume: 3 Pages: 1-1
  • Peer Reviewed / Open Access
• [Journal Article] Heat shock protein A4 controls cell migration and gastric ulcer healing. (2015)
  • Author(s): Sakurai T, Kashida H, Hagiwara S, Nishida N, Watanabe T, Fujita J, Kudo M.
  • Journal Title: Dig Dis Sci. Volume: 60 Issue: 4 Pages: 850-857
  • DOI: 10.1007/s10620-015-3561-8
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Cold-inducible RNA-binding protein (Cirp) promotes the development of liver cancer. (2015)
  • Author(s): Sakurai T, Yada N, Watanabe T, Arizumi T, Hagiwara S, Ueshima K, Nishida N, Fujita J, Kudo M.
  • Journal Title: Cancer Sci Volume: in press Issue: 4 Pages: 352-358
  • DOI: 10.1111/cas.12611
  • Peer Reviewed / Open Access
• [Journal Article] Heat shock protein A4/Apg-2 is required for stem/progenitor cell maintenance in intestinal inflammation. (2015)
  • Author(s): Adachi T, Sakurai T, Kashida H, Mine H, Hagiwara S, Matsui S, Yoshida K, Nishida N, Watanabe T, Itoh K, Fujita J, Kudo M.
  • Journal Title: Inflammatory Bowel Disease Volume: 21 Issue: 1 Pages: 31-39
  • DOI: 10.1097/mib.0000000000000244
  • Peer Reviewed / Open Access
• [Presentation] Locked Nucleic Acidsを用いた 血清中マイクロRNA定量と ソラフェニブ治療に対する反応予測 (2017)
  • Author(s): 西田直生志、岩西美奈、南知宏、千品寛和、河野匡志、有住忠晃、田北雅弘、矢田典久、依田広、萩原智、南康範、上嶋一臣、工藤正俊
  • Organizer: 第15回日本肝がん分子標的治療研究会（優秀演題）
• [Presentation] PD-L1陽性肝癌の臨床病理学的特徴と遺伝子変異プロファイル (2017)
  • Author(s): 西田直生志、工藤正俊
  • Organizer: 第103回日本消化器病学会総会 シンポジウム8「肝発癌メカニズムのパラダイムシフトとこれからの展望」
• [Presentation] US-US image fusion を用いた肝細胞癌へのラジオ波焼灼術の有用性 (2017)
  • Author(s): 南康範、西田直生志、工藤正俊
  • Organizer: 第103回日本消化器病学会総会 ワークショップ12「肝画像診断の進歩」
• [Presentation] Identification of fetal liver-type hepatocellular carcinoma based on a methylome analysis and its association with genetic alterations. (2016)
  • Author(s): Nishida N., Kudo M.
  • Organizer: 第24回日本消化器関連学会週間（第20回日本肝臓学会大会）
  • Place of Presentation: ポートピアホテル、神戸
  • Year and Date: 2016-11-03
• [Presentation] ゲノム・エピゲノム・染色体情報に基づいた肝癌の亜分類と転移再発予測 (2016)
  • Author(s): 西田直生志、工藤正俊
  • Organizer: 第52回日本肝癌研究会 パネルディスカッション 2 肝細胞癌の新たなサブクラス分類と治療ストラテジー
  • Place of Presentation: 虎の門ヒルズフォーラム、東京
  • Year and Date: 2016-07-01
• [Presentation] NASH 関連肝発癌における線維化進展と遺伝子変化 (2016)
  • Author(s): 萩原智、西田直生志、工藤正俊
  • Organizer: 第52回日本肝癌研究会 ワークショップ 2 非ウイルス性肝細胞癌の病態と分類
  • Place of Presentation: 虎の門ヒルズフォーラム、東京
  • Year and Date: 2016-07-01
• [Presentation] Classification of tumors based on the integrated profile of genetic and epigenetic alterations and the biological behavior of human hepatocellular carcinoma. (2015)
  • Author(s): Nishida N and Kudo M.
  • Organizer: 66th Annual meeting of the American Association for the Study of Liver Diseases (AASLD)
  • Place of Presentation: The Moscone Center, San Francisco, CA
  • Year and Date: 2015-11-13
  • Int'l Joint Research
• [Presentation] Tumor characteristics and genetic and epigenetic profile of human hepatocellular carcinoma. (2015)
  • Author(s): Nishida N and Kudo M.
  • Organizer: 第19回日本肝臓学会大会 International Session, Symposium 1. 「Hepatocellular carcinoma: Molecular approaches for diagnosis, prognosis, and therapy」
  • Place of Presentation: グランドプリンスホテル新高輪
  • Year and Date: 2015-10-08
• [Presentation] Epigenetics in HCC pathogenesis (2015)
  • Author(s): Nishida N
  • Organizer: 6th Asia-Pathific Primary Liver Cancer Expert Meeeting. Satellite 1. Basics, Genomics, Molecular Biology and Therapy
  • Place of Presentation: HYATT REGENCY, Osaka, Japan
  • Year and Date: 2015-07-03
  • Int'l Joint Research / Invited
• [Presentation] 分子生物学的特徴に基づいた肝癌のマネージメント (2015)
  • Author(s): 西田直生志、工藤正俊
  • Organizer: 第51回肝臓学会総会 シンンポジウム1「肝発癌研究と臨床への展開」
  • Place of Presentation: ホテル日航熊本、熊本
  • Year and Date: 2015-05-21
• [Presentation] 血清中マイクロRNAプロファイルとソラフェニブに対する肝細胞癌の反応予測 (2015)
  • Author(s): 西田直生志、工藤正俊
  • Organizer: 第51回肝臓学会総会 ワークショップ1「肝細胞癌の亜分類と個別化医療」
  • Place of Presentation: ホテル日航熊本、熊本
  • Year and Date: 2015-05-21
• [Presentation] 変異型HBx遺伝子の肝発癌促進における分子機序の解明 (2015)
  • Author(s): 萩原智、西田直生志、工藤正俊
  • Organizer: 第51回肝臓学会総会 ワークショップ4「肝病態を反映する新たなバイオマーカーの探索」
  • Place of Presentation: ホテル日航熊本、熊本
  • Year and Date: 2015-05-21
• [Book] 日本消化器病学会雑誌 (2017)
  • Author(s): 上嶋一臣、工藤正俊
  • Total Pages: 8
  • Publisher: 杏林舎
• [Book] がん遺伝子とがん抑制遺伝子。最新肝臓病学―日本臨床７３ 増刊号１ (2015)
  • Author(s): 西田直生志、工藤正俊
  • Total Pages: 6
  • Publisher: 日本臨床社
• [Book] 発がん予測バイオマーカーとしてのエピゲノム変化。最新肝臓病学-日本臨床７３ 増刊号１ (2015)
  • Author(s): 萩原智、西田直生志、工藤正俊
  • Total Pages: 5
  • Publisher: 日本臨床社