| Project/Area Number |
15K09029
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
iijima hiroko 兵庫医科大学, 医学部, 教授 (80289066)
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| Co-Investigator(Kenkyū-buntansha) |
田中 真二 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420)
藤元 治朗 兵庫医科大学, 医学部, 教授 (90199373)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 肝線維化 / 肝脂肪化 / 超音波 / shear wave / Elastography / 肝発癌リスク |
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| Outline of Final Research Achievements |
The risk of liver cancer was predicted using the combination of the following parameters: liver stiffness VTQ (>1.33 m/s),FPG(≧110 mg/dl), sex (male), age (≧55 years), and AFP (≧5 ng/ml). The study revealed that the total of 5 points was the highest risk of HCC. The increased expression of connective tissue growth factor (CTGF) associated with diabetes and obese was identified as a liver cancer-associated genome/bio-markers. One hundred and twenty-sixth patients who underwent liver biopsy and liver stiffness were analyzed to establish the regression equation between transient elastography (TE) and SWE, TE and SWE-Aixplorer, TE = 1.23 x SWE-Axplorer -0.40; TE and SWE-EPIQ, TE = 1.10 x SWE-EPIQ +0.06; TE and SWE-LOGIQ, TE = 1.82 x SWE-LOGIQ -1.18; TE and SWE-ACUSON, TE = 1.45 x SWE-ACUSON - 0.30; TE and SWE-Aplio, TE = 1.29 x SWE-Aplio -0.45.
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