Development of new diagnosis shear wave methods for liver fibrosis and steatosis

• Project/Area Number: 15K09029
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Hyogo Medical University
• Principal Investigator: iijima hiroko 兵庫医科大学, 医学部, 教授 (80289066)
• Co-Investigator(Kenkyū-buntansha): 田中 真二 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420) ; 藤元 治朗 兵庫医科大学, 医学部, 教授 (90199373)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝線維化 / 肝脂肪化 / 超音波 / shear wave / Elastography / 肝発癌リスク

Outline of Final Research Achievements

The risk of liver cancer was predicted using the combination of the following parameters: liver stiffness VTQ (>1.33 m/s),FPG(≧110 mg/dl), sex (male), age (≧55 years), and AFP (≧5 ng/ml). The study revealed that the total of 5 points was the highest risk of HCC. The increased expression of connective tissue growth factor (CTGF) associated with diabetes and obese was identified as a liver cancer-associated genome/bio-markers. One hundred and twenty-sixth patients who underwent liver biopsy and liver stiffness were analyzed to establish the regression equation between transient elastography (TE) and SWE, TE and SWE-Aixplorer, TE = 1.23 x SWE-Axplorer -0.40; TE and SWE-EPIQ, TE = 1.10 x SWE-EPIQ +0.06; TE and SWE-LOGIQ, TE = 1.82 x SWE-LOGIQ -1.18; TE and SWE-ACUSON, TE = 1.45 x SWE-ACUSON - 0.30; TE and SWE-Aplio, TE = 1.29 x SWE-Aplio -0.45.

Research Products

• [Journal Article] Changes in liver stiffness and steatosis among patients with hepatitis C virus infection who received direct-acting antiviral therapy and achieved sustained virological response. (2018)
  • Author(s): Kobayashi N, Iijima H, Tada T, Kumada T, Yoshida M, Aoki T, Nishimura T, Nakano C, Takata R, Yoh K, Ishii A, Takashima T, Sakai Y, Aizawa N, Nishikawa H, Ikeda N, Iwata Y, Enomoto H, Hirota S, Fujimoto J, Nishiguchi S.
  • Journal Title: Eur J Gastroenterol Hepatol. Volume: 30(5) Issue: 5 Pages: 546-551
  • DOI: 10.1097/meg.0000000000001106
  • Peer Reviewed
• [Journal Article] A new method to evaluate hepatic steatosis using ultrasound "Attenuation imaging" (2018)
  • Author(s): 飯島 尋子, 西村 貴士, 多田 俊史, 中野 智景, 青木 智子, 高嶋 智之, 池田直人, 會澤 信弘, 西川 浩樹, 岩田 恵典, 榎本 平之, 藤元 治朗, 鹿毛 政義, 熊田 卓, 西口 修平, 矢野 博久.
  • Journal Title: Kanzo Volume: 59 Issue: 1 Pages: 65-67
  • DOI: 10.2957/kanzo.59.65
  • NAID: 130006321761
  • ISSN: 0451-4203, 1881-3593
  • Peer Reviewed
• [Journal Article] Prediction of development of hepatocellular carcinoma using a new scoring system involving virtual touch quantification in patients with chronic liver diseases. (2017)
  • Author(s): Aoki T, Iijima H, Tada T, Kumada T, Nishimura T, Nakano C, Kishino K, Shimono Y, Yoh K, Takata R, Ishii A, Takashima T, Sakai Y, Aizawa N, Nishikawa H, Ikeda N, Iwata Y, Enomoto H, Hirota S, Fujimoto J, Nishiguchi S.
  • Journal Title: J Gastroenterol. Volume: 52(1) Issue: 1 Pages: 104-112
  • DOI: 10.1007/s00535-016-1228-7
  • Peer Reviewed
• [Journal Article] Comparison of FIB-4 index and aspartate aminotransferase to platelet ratio index on carcinogenesis in chronic hepatitis B treated with entecavir. (2017)
  • Author(s): Nishikawa H, Nishijima N, Enomoto H, Sakamoto A, Nasu A, Komekado H, Nishimura T, Kita R, Kimura T, Iijima H, Nishiguchi S, Osaki Y.
  • Journal Title: J Cancer. Volume: 8(2) Issue: 2 Pages: 152-161
  • DOI: 10.7150/jca.16523
  • Peer Reviewed
• [Journal Article] Clinical implication of serum Wisteria floribunda Agglutinin-Positive Mac-2-binding protein in treatment naïve chronic hepatitis B. (2017)
  • Author(s): Ishii A, Nishikawa H, Enomoto H, Iwata Y, Kishino K, Shimono Y, Hasegawa K, Nakano C, Takata R, Nishimura T, Yoh K, Aizawa N, Sakai Y, Ikeda N, Takashima T, Iijima H1 Nishiguchi S.
  • Journal Title: Hepatol Res. Volume: 47 Issue: 2 Pages: 204-215
  • DOI: 10.1111/hepr.12703
  • Peer Reviewed
• [Journal Article] Impact of Virtual Touch Quantification in Acoustic Radiation Force Impulse for Skeletal Muscle Mass Loss in Chronic Liver Diseases. (2017)
  • Author(s): Nishikawa H, Nishimura T, Enomoto H, Iwata Y, Ishii A, Miyamoto Y, Ishii N, Yuri Y, Takata R, Hasegawa K, Nakano C, Yoh K, Aizawa N, Sakai Y, Ikeda N, Takashima T, Nishiguchi S, Iijima H.
  • Journal Title: Nutrients. Volume: 9(6) Issue: 6 Pages: 620-620
  • DOI: 10.3390/nu9060620
  • Peer Reviewed
• [Journal Article] Prognostic significance of low skeletal muscle mass compared with protein-energy malnutrition in liver cirrhosis. (2017)
  • Author(s): Nishikawa H, Enomoto H, Ishii A, Iwata Y, Miyamoto Y, Ishii N, Yuri Y, Takata R, Hasegawa K, Nakano C, Nishimura T, Yoh K, Aizawa N, Sakai Y, Ikeda N, Takashima T, Iijima H, Nishiguchi S.
  • Journal Title: Hepatol Res. Volume: 47(10) Issue: 10 Pages: 1042-1052
  • DOI: 10.1111/hepr.12843
  • Peer Reviewed
• [Journal Article] Proposal of a predictive model for advanced fibrosis containing Wisteria floribunda agglutinin-positive Mac-2-binding protein in chronic hepatitis C. (2016)
  • Author(s): Nishikawa H, Takata R, Enomoto H, Kazunori Y, Kishino K, Shimono Y, Iwata Y, Hasegawa K, Nakano C, Nishimura T, Aizawa N, Sakai Y, Ikeda N, Takashima T, Ishii A, Iijima H, Nishiguchi S.
  • Journal Title: Hepatol Res. Volume: 47（3） Issue: 3
  • DOI: 10.1111/hepr.12724
  • Peer Reviewed
• [Journal Article] Improvement in the Amino Acid Imbalance in Hepatitis C Virus Infected Patients After Viral Eradication by Interferon Treatment. (2016)
  • Author(s): Enomoto H, Nishikawa H, Ikeda N, Aizawa N, Sakai Y, Yoh K, Takata R, Hasegawa K, Nakano C, Nishimura T, Ishii A, Takashima T, Iwata Y, Iijima H, Nishiguchi S.
  • Journal Title: Hepat Mon. Volume: 16（6） Issue: 6 Pages: 575-583
  • DOI: 10.5812/hepatmon.35824
  • Peer Reviewed
• [Journal Article] Clinical significance of serum Wisteria floribunda agglutinin positive Mac-2-binding protein level and high-sensitivity C-reactive protein concentration in autoimmune hepatitis. (2016)
  • Author(s): Nishikawa H, Enomoto H, Iwata Y, Hasegawa K, Nakano C, Takata R, Nishimura T, Yoh K, Aizawa N, Sakai Y, Ikeda N, Takashima T, Iijima H, Nishiguchi S.
  • Journal Title: Hepatol Res. Volume: 46（7） Issue: 7 Pages: 613-621
  • DOI: 10.1111/hepr.12596
  • Peer Reviewed
• [Journal Article] Computer-aided diagnosis for estimating the malignancy grade of hepatocellular carcinoma using contrast-enhanced ultrasound: an ROC observer study. (2016)
  • Author(s): Sugimoto K, Shiraishi J, Tanaka H, Tsuchiya K, Aso K, Kobayashi Y, Iijima H, Moriyasu F.
  • Journal Title: Liver Int. Volume: 36（7） Issue: 7 Pages: 1026-1032
  • DOI: 10.1111/liv.13043
  • Peer Reviewed
• [Journal Article] Impact of Wisteria floribunda Agglutinin-Positive Mac-2-Binding Protein in Patients with Hepatitis C Virus-Related Compensated Liver Cirrhosis. (2016)
  • Author(s): Hasegawa K, Takata R, Nishikawa H, Enomoto H, Ishii A, Iwata Y, Miyamoto Y, Ishii N, Yuri Y, Nakano C, Nishimura T, Yoh K, Aizawa N, Sakai Y, Ikeda N, Takashima T, Iijima H, Nishiguchi S.
  • Journal Title: Int J Mol Sci. Volume: 17（9） Issue: 9 Pages: 1500-1500
  • DOI: 10.3390/ijms17091500
  • Peer Reviewed
• [Journal Article] Clinical significance of serum wisteria floribunda agglutinin-positive Mac-2-binding protein level in non-alcoholic steatohepatitis. (2016)
  • Author(s): Nishikawa H, Enomoto H, Iwata Y, Kishino K, Shimono Y, Hasegawa K, Nakano C, Takata R, Yoh K, Nishimura T, Aizawa N, Sakai Y, Ikeda N, Takashima T, Ishii A, Iijima H, Nakamura H, Nishiguchi S.
  • Journal Title: Hepatol Res. Volume: 46（12） Issue: 12 Pages: 1194-1202
  • DOI: 10.1111/hepr.12662
  • Peer Reviewed
• [Journal Article] Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein for patients with chronic hepatitis B and C: a comparative study. (2016)
  • Author(s): Nishikawa H, Enomoto H, Iwata Y, Kishino K, Shimono Y, Hasegawa K, Nakano C, Takata R, Nishimura T, Yoh K, Ishii A, Aizawa N, Sakai Y, Ikeda N, Takashima T, Iijima H, Nishiguchi S.
  • Journal Title: J Viral Hepat. Volume: 23（12） Issue: 12 Pages: 977-984
  • DOI: 10.1111/jvh.12575
  • Peer Reviewed
• [Journal Article] 【超音波ならではを集める!】 エラストグラフィーの基礎と臨床 Shear waveの経時的推移から診た発癌リスク解析と予後予測． (2015)
  • Author(s): 青木 智子, 田中 弘教, 吉田 昌弘, 中野 智景, 橋本 健二, 石井 昭生, 高嶋 智之, 會澤 信弘, 池田 直人, 榎本 平之, 斎藤 正紀, 廣田 誠一, 藤元 治朗, 西口 修平, 飯島 尋子．
  • Journal Title: Rad Fan Volume: 13 Pages: 54-6
• [Journal Article] Usefulness of liver fibrosis markers ELF in chronic hepatitis (2015)
  • Author(s): 高嶋 智之，飯島 尋子，青木 智子，中野 智景，會澤 信弘，岸野 恭平，霜野良弘，長谷川 国広，高田 亮，楊 和典，石井 昭生，坂井 良行，西村 貴士，西川 浩樹，岩田 恵典，池田 直人，榎本 平之，廣田 誠一，藤元 治朗，矢野 博久，中島 収，鹿毛 政義，西口 修平.
  • Journal Title: Kanzo Volume: 56 Issue: 10 Pages: 543-545
  • DOI: 10.2957/kanzo.56.543
  • NAID: 130005106527
  • ISSN: 0451-4203, 1881-3593
  • Peer Reviewed
• [Presentation] Kupffer cell dysfunction in patients with chronic liver disease: Investigating the phagocytic function using ultrasound contrast microbubbles. (2017)
  • Author(s): Jiro Fujimoto, Naoki Uyama, Shun-ichi Sasaki, Hiroko Iijima
  • Organizer: 19th International Symposium on Cells of the Hepatic Sinusoid
  • Int'l Joint Research
• [Presentation] Enhanced patterns by intraoperative contrast-enhanced ultrasonography predicts the outcomes in patients with hepatocellular carcinoma after curative liver resection. (2017)
  • Author(s): Ikuo Nakamura, Etsuro Hatano, Toshihiro Okada, Yasukane Asano, Uyama Naoki, Kazuhiro Suzumura, Masaharu Tada, Yuichi Kondo, Kenjiro Iida, Seikan Hai, Hideaki Iwama, Hideaki Sueoka, Hiroko Iijima, Jiro Fujimoto.
  • Organizer: The 68rd Annual Meeting of the American Association for the Study of Liver Diseases（AASLD2017）
  • Int'l Joint Research
• [Presentation] Shear wave elastography for the diagnosis of esophagogastric varices. (2017)
  • Author(s): Hiroko Iijima, Takashi Nishimura, Chikage Nakano, Tomoko Aoki, Yuho Miyamoto Noriko Ishii, Yukihisa Yuri, Kunihiro Hasegawa, Ryo Takata, Kazunori Yo, Akio Ishii, Tomoyuki Takashima, Yoshiyuki Sakai, Nobuhiro Aizawa, Naoto Ikeda, Hiroki Nishikawa, Yoshinori Iwata, Hirayuki Enomoto, Shuhei Nishiguchi, Jiro Fujimoto.
  • Organizer: UEG Week 2017
  • Int'l Joint Research
• [Presentation] 肝疾患を粘性と減衰で診る. (2017)
  • Author(s): 飯島 尋子.
  • Organizer: 日本超音波医学会第90回学術集会
• [Presentation] び慢性肝疾患におけるShear Wave エラストグラフィの担う役割 －最新Shear Wave エラストグラフィ“ElastQ”－. (2017)
  • Author(s): 飯島 尋子.
  • Organizer: 日本超音波医学会第90回学術集会
• [Presentation] Shear wave 伝搬速度に影響を与える因子の定量的検討を基にした肝疾患診断法の研究. (2017)
  • Author(s): 飯島 尋子.
  • Organizer: 日本超音波医学会第90回学術集会
• [Presentation] 減衰イメージングによる新しい脂肪肝診断とNASH 診断への可能性－ CAP とCT と比較して－. (2017)
  • Author(s): 飯島 尋子，西村 貴士，吉田 昌弘，小原 由佳，中野 智景，青木 智子，會澤信弘，池田 直人，廣田 誠一，西口 修平.
  • Organizer: 日本超音波医学会第90回学術集会
• [Presentation] The diagnostic accuracy for liver fibrosis using shear wave elastography according to etiology of liver disease and the presence or absence of anti-viral therapy. (2016)
  • Author(s): Takashi Nishimura,Chikage Nakano,Yuho Miyamoto,Noriko Ishii,Yukihisa Yuri,Tomoko Aoki,Kunihiro Hasegawa,Ryo Takata,Kasunori Yo,Akio Ishii,Tomoyuki Tkashima,Yoshiyuki Sasaki,Nobuhiro Aizawa,Naoto Ikeda, Hiroki Nishikawa, Yoshinori Iwata, Hirayuki Enomoto,Seiichi Hirota,Jiro Fujimoto,Shuhei Nishiguchi,Hiroko Iijima.
  • Organizer: The 67rd Annual Meeting of the American Association for the Study of Liver Diseases（AASLD2016）
  • Place of Presentation: Boston
  • Year and Date: 2016-11-11
  • Int'l Joint Research
• [Presentation] Shear wave elastography による肝腫瘍診断. (2016)
  • Author(s): 西村 貴士, 西口 修平, 飯島 尋子.
  • Organizer: 第20回日本肝臓学会大会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県・神戸市）
  • Year and Date: 2016-11-03
• [Presentation] 糖尿病を有する肝線維化進展例は肝癌高リスク群である. (2016)
  • Author(s): 青木 智子, 西口 修平, 飯島 尋子.
  • Organizer: 第20回日本肝臓学会大会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県・神戸市）
  • Year and Date: 2016-11-03
• [Presentation] Contrast enhanced ultrasound in the diagnosis of hepatocellular. (2016)
  • Author(s): Takashi Nishimura, Iijima Hiroko.
  • Organizer: The 12th Single Topic Conference
  • Place of Presentation: Hotel Nikko Kanazawa（石川県・金沢市）
  • Year and Date: 2016-09-22
  • Int'l Joint Research
• [Presentation] The differential diagnostic ability of hepatocellular carcinoma using shear wave elastoglaphy. (2016)
  • Author(s): Takashi Nishimura, Chikage Nakano, Tomoko Aoki, Nobuhiro Aizawa, Hiroki Nishikawa, Hirayuki Enomoto, Esuto Hatano, Seiichi Hirota, Jiro Fujimoto, Shuhei Nishiguchi, Hiroko Iijima.
  • Organizer: The 12th Single Topic Conference
  • Place of Presentation: Hotel Nikko Kanazawa（石川県・金沢市）
  • Year and Date: 2016-09-22
  • Int'l Joint Research
• [Presentation] 門脈圧亢進症における肝脾の線維化の超音波画像診断. (2016)
  • Author(s): 飯島 尋子, 近藤 礼一郎, 西村 純子, 西村 貴士, 中野 智景, 會澤 信弘, 池田 直人, 西口 修平, 廣田 誠一, 矢野 博久, 鹿毛 政義.
  • Organizer: 第23回日本門脈圧亢進症学会総会
  • Place of Presentation: 神戸国際展示場（兵庫県・神戸市）
  • Year and Date: 2016-09-09
• [Presentation] 超音波shear wave法と肝内脈管到達時間からみた門脈圧亢進症. (2016)
  • Author(s): 西村 貴士, 中野 智景, 青木 智子, 石井 昭生, 會澤 信弘, 岩田 恵典, 榎本平之, 西口 修平, 飯島 尋子.
  • Organizer: 第23回日本門脈圧亢進症学会総会
  • Place of Presentation: 神戸国際展示場（兵庫県・神戸市）
  • Year and Date: 2016-09-09
• [Presentation] 肝線線維化診断と発癌. (2016)
  • Author(s): 飯島 尋子
  • Organizer: 第65回日本医学検査学会
  • Place of Presentation: 神戸国際展示場（兵庫県・神戸市）
  • Year and Date: 2016-09-03
• [Presentation] 2D-Shear wave ElastographyによるDispersion(粘性)Imaging. (2016)
  • Author(s): 飯島 尋子.
  • Organizer: 第89回日本超音波医学会学術集会
  • Place of Presentation: 国立京都国際会議場（京都府・京都市）
  • Year and Date: 2016-05-27
• [Presentation] Shear wave法６機種による肝繊維化診断能とetiology 別肝繊維化の検討. (2016)
  • Author(s): 西村 貴士, 西口 修平，飯島 尋子.
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県・千葉市）
  • Year and Date: 2016-05-19
• [Presentation] 慢性Ｂ型肝炎における肝脂肪化の検討. (2016)
  • Author(s): 会澤 信弘, 飯島 尋子, 西口 修平.
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県・千葉市）
  • Year and Date: 2016-05-19
• [Presentation] SVR後肝癌例はIFN治療前後の肝硬度が高い. (2016)
  • Author(s): 青木 智子, 飯島 尋子, 西口 修平.
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県・千葉市）
  • Year and Date: 2016-05-19
• [Presentation] NASH症例のKupffer貧食能は可逆性である. (2016)
  • Author(s): 青木 智子, 飯島 尋子, 西口 修平.
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県・千葉市）
  • Year and Date: 2016-05-19
• [Presentation] 肝細胞腺腫４例の画像検査と病理組織学的検討. (2016)
  • Author(s): 西村 貴士, 西口 修平，飯島 尋子.
  • Organizer: 第52回日本肝臓学会総会
  • Place of Presentation: ホテルニューオータニ幕張（千葉県・千葉市）
  • Year and Date: 2016-05-19
• [Presentation] The latest in the noninvasive diagnosis of liver diseases. (2016)
  • Author(s): Iijima Hiroko.
  • Organizer: JSGE-APAGE Joint Conference The 7th Asian Pacific Topic Conference.
  • Place of Presentation: Keio Plaza Hotel（東京都・新宿区）
  • Year and Date: 2016-04-19
  • Int'l Joint Research
• [Presentation] Usefulness of non-invasive assessment of liver fibrosis using six defferent ultrasound elastography devices in patients with chronic hepatitis and the difference of liver stiffness between HBV-related chronic hepatitis and non-HBV-related chronic hepatitis. (2016)
  • Author(s): Nishimura Takashi, Aoki Tomoko, Nakano Chikage, Kishino Kyohei, Shimono Yoshihiro, Hasegawa Kunihiro, Takata Ryo, Yo Kazunori, Takashima Tomoyuki, Aizawa Nobuhiro, Ikeda Naoto, Iwata Yoshinori, Nishikawa Hiroki, Enomoto Hirayuki,Hirota Seiichi, Fujimoto Jiro, Nishiguchi Shuhei, Iijima Hiroko.
  • Organizer: JSGE-APAGE Joint Conference The 7th Asian Pacific Topic Conference.
  • Place of Presentation: Keio Plaza Hotel（東京都・新宿区）
  • Year and Date: 2016-04-19
  • Int'l Joint Research
• [Presentation] 非侵襲的肝線維化診断法shear wave法を用いた肝線維化の検討． (2016)
  • Author(s): 西村 貴士，青木 智子，中野 智景，會澤 信弘，池田 直人，西川 浩樹，岩田 恵典，榎本 平之，西口 修平，飯島 尋子.
  • Organizer: 第113回日本内科学会講演会
  • Place of Presentation: 東京国際フォーラム（東京都・千代田区）
  • Year and Date: 2016-04-15
• [Presentation] Pathogenesis of portal hypertension and the intrahepatic hemodynamics in liver cirrhosis. (2016)
  • Author(s): Nishimura Takashi, Nakano Chikage, Aoki Tomoko, Shimono Yoshihiro, Kishino Kyohei, Hasegawa Kunihiro, Takata Ryo, Yoh Kazunori, Ishii Akio, Takashima Tomoyuki, Sakai Yoshiyuki, Aizawa Nobuhiro, Ikeda Naoto, Nishikawa Hiroki, Iwata Yoshinori, Enomoto Hirayuki, Nishiguchi Shuhei, Iijima Hiroko.
  • Organizer: The 25th Asian Pacific Association for the Study of the Liver (APASL 2016)The 25th Asian Pacific Association for the Study of the Liver (APASL 2016)
  • Place of Presentation: Tokyo（JAPAN)
  • Year and Date: 2016-02-22
  • Int'l Joint Research
• [Presentation] Retrospective cohort study for liver carcinogenesis prediction among HBs antigen negative and anti-HCV antibody negative hepatitis patients. (2015)
  • Author(s): Aoki Tomoko, Iijima Hiroko, Nishimura Takashi, Nakano Chikage, Takashima Tomoyuki, Aizawa Nobuhiro, Ikeda Naoto, Tanaka Hironori,Iwata Yoshinori, Enomoto Hirayuki, Saito Masaki, Nishiguchi Shuhei.
  • Organizer: The 66rd Annual Meeting of the American Association for the Study of Liver Diseases（AASLD2015）
  • Place of Presentation: San Francisco（USA）
  • Year and Date: 2015-11-17
  • Int'l Joint Research
• [Presentation] Usefulness of spleen stiffness measurement using VTQ in diagnosing esophagogastric varices including the relationship with collateral vessels. (2015)
  • Author(s): Nakano Chikage, Nishimura Takashi, Aoki Tomoko, Kishino Kyohei, Shimono Yoshihiro, Hasegawa Kunihiro, Takata Ryo, Yoh Kazunori, Ishii Akio, Takashima Tomoyuki, Sakai Yoshiyuki, Aizawa Nobuhiro, Ikeda Naoto, Nishikawa Hiroki, Iwata Yoshinori, Enomoto Hirayuki, Nishiguchi Shuhei, Iijima Hiroko.
  • Organizer: The 66rd Annual Meeting of the American Association for the Study of Liver Diseases（AASLD2015）
  • Place of Presentation: San Francisco（USA)
  • Year and Date: 2015-11-16
  • Int'l Joint Research
• [Presentation] Usefulness of ultrasound elastography in assessing liver fibrosis in patients with chronic hepatitis and the difference of liver stiffness between HBV-related chronic hepatitis and non-HBV-related chronic hepatitis. (2015)
  • Author(s): Nishimura Takashi, Nakano Chikage, Kishino Kyohei, Shimono Yoshihiro, Hasegawa Kunihiro, Takata Ryo, Yoh Kazunori, Ishii Akio, Takashima Tomoyuki, Sakai Yoshiyuki, Aizawa Nobuhiro, Ikeda Naoto, Nishikawa Hiroki, Iwata Yoshinori, Nishiguchi Shuhei, Iijima Hiroko.
  • Organizer: The 66rd Annual Meeting of the American Association for the Study of Liver Diseases（AASLD2015）
  • Place of Presentation: San Francisco（USA)
  • Year and Date: 2015-11-15
  • Int'l Joint Research
• [Presentation] Noninvasive diagnosis of malignant liver tumors using shear wave ultrasound elastography． (2015)
  • Author(s): ijima Hiroko, Nishimura Takashi, Nakano Chikage, Shiomi Chizu, Aoki Tomoko, Yoh Kazunori, Ishii Akio, Takashima Tomoyuki, Sakai Yoshiyuki, Aizawa Nobuhiro, Nishikawa Hiroki, Ikeda Naoto, Iwata Yoshinori, Enomoto Hirayuki, Hirota Seiichi, Fujimoto Jiro, Nishiguchi Shuhei.
  • Organizer: International Liver Cancer Association 9th Annual Conference（ILCA 2015）
  • Place of Presentation: Paris（France)
  • Year and Date: 2015-09-05
  • Int'l Joint Research
• [Presentation] VF map scores(Virtual Touch Quantification, Fasting Plasma Glucose, Male, Age, Platelets)for prediction of Hepato-Carcinogenesis. (2015)
  • Author(s): Aoki Tomoko, Iijima Hiroko, Nakano Chikage, Ishii Akio, Takashima Tomoyuki, Aizawa Nobuhiro, Ikeda Naoto, Iwata Yoshinori, Enomoto Hirayuki, Hirota Seiishi, Fujimoto Jiro, Nishiguchi Shuhei.
  • Organizer: The 6th Asia-Pacific Primary Liver Cancer Expert Meeting(APPLE2015)
  • Place of Presentation: OSAKA（JAPAN)
  • Year and Date: 2015-07-03
  • Int'l Joint Research
• [Presentation] 肝臓の硬さ診断：その精度と使途． (2015)
  • Author(s): 飯島 尋子，柴田 陽子，吉田 昌弘，中野 智景，青木 智子，田中 弘教，廣田誠一，會澤 信弘，西口 修平，藤元 治朗．
  • Organizer: 日本超音波医学会第88回学術集会
  • Place of Presentation: グランドプリンスホテル新高輪 国際館パミール（東京）
  • Year and Date: 2015-05-23
• [Book] 肝疾患診療に役立つ 肝線維化評価テキスト (2017)
  • Author(s): 飯島 尋子
  • Total Pages: 140
  • Publisher: 文光堂
• [Book] プリンシプル消化器疾患の臨床３ ここまできた肝臓病診療 (2017)
  • Author(s): 飯島 尋子
  • Total Pages: 432
  • Publisher: 中山書店
• [Book] 新版 放射線医科学―生体と放射線・電磁波・超音波― (2016)
  • Author(s): 飯島 尋子.
  • Total Pages: 192
  • Publisher: 医療科学社