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Activation machinery of tissue-resident innate IL-5-producing cells and their roles in inflammatory diseases and fibrosis

Research Project

Project/Area Number 15K09036
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Gastroenterology
Research InstitutionKawasaki Medical School (2016-2017)
National Center for Global Health and Medicine (2015)

Principal Investigator

Iseki Masanori  川崎医科大学, 医学部, 講師 (30532353)

Co-Investigator(Kenkyū-buntansha) 高木 智  国立研究開発法人国立国際医療研究センター, その他部局等, 免疫制御研究部長 (10242116)
Project Period (FY) 2015-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords自然リンパ球 / ILC2 / 好酸球 / 炎症 / IL-5 / 線維化
Outline of Final Research Achievements

Recently, novel Th2 cytokine-producing cells, type 2 innate lymphoid cells (ILC2s) were identified and analyzed as an important cells for various inflammatory diseases. In this study, we examined a role of ILC2s in liver inflammation and fibrosis with IL-5 reporter mice that we newly generated. We found that IL-5 production from ILC2s and eosinophil activation are not necessary for the development of liver inflammation and the following fibrosis. We also found that ILC2s were activated by intraperinoteal administration of oil (e.g. mineral oil and olive oil), and this activation was mediated by peritoneal cells, especially macrophages and cytokine IL-33 and/or TSLP.

Report

(4 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • Research Products

    (15 results)

All 2018 2017 2016 2015

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (11 results)

  • [Journal Article] Cyclosporin A indirectly attenuates activation of group 2 innate lymphoid cells in papain-induced lung inflammation.2018

    • Author(s)
      Kudo F, Ikutani M, Iseki M, Takaki S.
    • Journal Title

      Cell Immunology

      Volume: 323 Pages: 33-40

    • DOI

      10.1016/j.cellimm.2017.10.010

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.2017

    • Author(s)
      Ikutani M, Tsuneyama K, Kawaguchi M, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, Takatsu K.
    • Journal Title

      JCI Insight.

      Volume: 2 Issue: 7

    • DOI

      10.1172/jci.insight.90721

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] IL-10 production in murine IgM+ CD138hi cells is driven by Blimp-1 and downregulated in class-switched cells.2017

    • Author(s)
      Nao Suzuki-Yamazaki
    • Journal Title

      European Journal of Immunology

      Volume: 47 Issue: 3 Pages: 493-503

    • DOI

      10.1002/eji.201646549

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Specific disruption of Lnk in murine endothelial progenitor cells promotes dermal wound healing via enhanced vasculogenesis, activation of myofibroblasts, and suppression of inflammatory cell recruitment2016

    • Author(s)
      Jun Hee Lee, Seung Taek Ji, Jaeho Kim, Satoshi Takaki, Takayuki Asahara, Young-Joon Hong, and Sang-Mo Kwon
    • Journal Title

      Stem Cell Research & Therapy

      Volume: 7 Issue: 1 Pages: 158-158

    • DOI

      10.1186/s13287-016-0403-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] BST-1/CD157 on B cells negatively regulates Toll-like receptor signaling2017

    • Author(s)
      Masanori Iseki, Ayano Yahagi, Katsuhiko Ishihara
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Activation of NK/group1-innate lymphoid cells in adipose tissues depends on the composition of fatty acids in high fat diet2017

    • Author(s)
      Yukari Saito, Taizo Mori, Yuki I. Kawamura, Taeko Dohi, Satoshi Takaki
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Disruption of Lnk increases severity of dextran sulfate sodium-induced acute colonic inflammation2017

    • Author(s)
      Mari Tenno, Satoshi Takaki
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Chronic IL-33-induced inflammation results in pulmonary arterial hypertrophy2017

    • Author(s)
      Masashi Ikutani, Koichi Tsuneyama, Susumu Nakae, Kiyoshi Takatsu, Satoshi Takaki
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Related Report
      2017 Annual Research Report
  • [Presentation] Lnk/Sh2b3 regulates adipose inflammation and glucose tolerance through group1-ILCs2017

    • Author(s)
      Taizo Mori, Nao Yamazaki, Satoshi Takaki
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Related Report
      2017 Annual Research Report
  • [Presentation] IL-10 derived from IgM+CD138hi cells support the antigen-specific antibody production2016

    • Author(s)
      Nao YAMAZAKI, Satoshi TAKAKI
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Lnk/Sh2b3, and autoimmune disease-associated gene, prevents adipose tissue inflammation by controlling IL-15-dependent cell fuctions2016

    • Author(s)
      Taizo MORI, Nao YAMAZAKI, Satoshi TAKAKI
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Chronic IL-33 treatment results in pulmonary arterial hypertrophy mediated by ILC2s and eosinophils2016

    • Author(s)
      Masashi IKUTANI, Koichi TSUNEYAMA, Fujimi KUDO, Kiyoshi TAKATSU, Satoshi TAKAKI
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Lack of microbiota revealed the role for BST-1/CD157 to maintain the homeostasis at mucosa-MLN interface2016

    • Author(s)
      Katsuhiko ISHIHARA, Ayano YAHAGI, Takaaki NISHIMOTO, Masanori ISEKI
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-05
    • Related Report
      2016 Research-status Report
  • [Presentation] Germinal center B cell survivial and optimal IgE production are controled by Lnk/Sh2b family adaptor protein Aps/Sh2b22015

    • Author(s)
      井関將典、工藤藤美、高木智
    • Organizer
      第44回日本免疫学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Lnk/Sh2bファミリーアダプター分子Aps/Sh2b2による胚中心形 成およびIgE産生制御2015

    • Author(s)
      井関將典、工藤藤美、高木智
    • Organizer
      第1回3NC合同リトリート
    • Place of Presentation
      国立国際医療研究センター(戸山)
    • Year and Date
      2015-08-18
    • Related Report
      2015 Research-status Report

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Published: 2015-04-16   Modified: 2019-03-29  

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