Study of IPMN-related carcinogenesis

• Project/Area Number: 15K09041
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: Tada Minoru 東京大学, 医学部附属病院, 講師 (80302719)
• Co-Investigator(Kenkyū-buntansha): 立石 敬介 東京大学, 医学部附属病院, 講師 (20396948) ; 毛利 大 東京大学, 医学部附属病院, 助教 (20582513) ; 松原 三郎 東京大学, 医学部附属病院, 助教 (40750550)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 膵癌 / IPMN / 膵がん

Outline of Final Research Achievements

Intraductal papillary mucinous neoplasm (IPMN) are considered as the high risk group for development of pancreatic cancer, however the molecular mechanism of IPMN still remains elucidated. We previously reported that carcinogenic risk of the pancreas with cystic lesions including IPMN was as high as 0.95% per year. IPMN are classified to the two types including MD-IPMN and BD-IPMN. In this study, we compare the molecular characteristics of the tissues isolated by laser micro dissection.

Research Products

• [Journal Article] Prevalence of Pancreatic Cystic Lesions Is Associated With Diabetes Mellitus and Obesity: An Analysis of 5296 Individuals Who Underwent a Preventive Medical Examination. (2017)
  • Author(s): Mizuno S, Isayama H, Nakai Y, Yoshikawa T, Ishigaki K, Matsubara S, Yamamoto N, Ijichi H, Tateishi K, Tada M, Hayashi N, Koike K.
  • Journal Title: Pancreas Volume: 46 Issue: 6 Pages: 801-805
  • DOI: 10.1097/mpa.0000000000000833
  • Peer Reviewed
• [Journal Article] IPMN and pancreatic cyst as high risk of pancreatic cancer (2015)
  • Author(s): Tada M, Takagi K, Kawakubo K,Takahara N, Takahashi R, Yamamoto K, Hamada T, Mizuno S, Miyabayashi K, Mohri D, Matsubara S, Kogure H, Nakai Y, Yamamoto N, Sasaki T, Sasahira N, Hirano K, Ijichi H, Tateishi K, Isayama H, Koike K et.al.
  • Journal Title: Nippon Shokakibyo Gakkai Zasshi Volume: 112 Issue: 8 Pages: 1474-1478
  • DOI: 10.11405/nisshoshi.112.1474
  • NAID: 130005091881
  • ISSN: 0446-6586, 1349-7693
  • Peer Reviewed