Next-generation sequencing of pancreatic juice to diagnose malignant intraductal papillary mucinous tumor
| Project/Area Number |
15K09044
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Research Collaborator |
ENOMOTO Nobuyuki 山梨大学, 大学院総合研究部, 教授 (20251530)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | IPMN / 膵液 / 次世代シークエンス / 膵管内乳頭粘液性腫瘍 / 遺伝子異常 / 次世代シークエンサー / 遺伝子解析 |
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| Outline of Final Research Achievements |
Intraductal papillary mucinous neoplasms (IPMNs) are recognized as one of the risk factors and precursor of pancreatic cancer. To diagnose malignant IPMN before surgery, we conducted gene analysis of resected IPMN by next-generation sequencing and identified TP53 mutation and SMAD4 loss as malignant markers for IPMN. Moreover, we tried to detect these gene alterations with pancreatic juice samples which could be obtained before surgical operation, and we succeeded to detect TP53 mutations in pancreatic juice samples. In the future, we should develop methods to detect these gene alterations with blood samples.
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Report
(4 results)
Research Products
(9 results)
